Key Product Details

Species Reactivity

Multi-Species

Applications

Western Blot, Neutralization, Immunoprecipitation

Label

Biotin

Antibody Source

Monoclonal Mouse IgG1 Clone # 335636
View all Oxidized PTP Active Site Primary Antibodies »

Product Specifications

Immunogen

KLH-coupled perfomic acid oxidized synthetic peptide
VHCSAG

Specificity

Detects Oxidized PTP Active Site. Will react with any oxidized phosphatase containing the consensus sequence. Detects oxidized but not unoxidized DEP-1, PTP1B, TC-PTP, and SHP-2. Other phosphatases have not been tested.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Oxidized PTP Active Site Antibody (335636) [Biotin]

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Neutralization

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Oxidized PTP Active Site

Oxidation of the essential cysteine in the active site of protein tyrosine phosphatases (PTPs) is believed to play an important role in regulating the activity of these enzymes. Rapid, oxidant-dependent inhibition of phosphatases such as PTP1B, TC-PTP and SHP-2 may play a role in fine tuning the responsiveness of receptor tyrosine kinases for growth factors. The initial oxidation to a sulfenic acid (-SOH) is reversible, but oxidation can progress to an irreversible sulfonic acid (-SO3H) that can be detected by antibodies made against an oxidized peptide containing the PTP active site consensus sequence.

Long Name

Oxidized Protein Tyrosine Phosphatase Active Site

Additional Oxidized PTP Active Site Products

Product Documents for Oxidized PTP Active Site Antibody (335636) [Biotin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Oxidized PTP Active Site Antibody (335636) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Epigenetics
Phosphatases and Regulators

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FAQs

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