Biological ActivityEndogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.
(Modifications: Arg-20 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors.
Mahata et al.
Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Kamohara et al.
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
Reviews for PAMP-20 (human)
There are currently no reviews for this product. Be the first to review PAMP-20 (human) and earn rewards!
Have you used PAMP-20 (human)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image