Biological ActivityPAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.
(Modifications: Arg-20 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors.
Mahata et al.
Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Kamohara et al.
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