PAMP-20 (human)

Name: PAMP-20 (human)
Brand: Tocris Bioscience
SKU: 6552
Price: 210 USD
Availability: InStock

Tocris Bioscience | Catalog # 6552

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Citations (1)

Product Documents

MRGPRX2 agonist; also non-competitive nAChR antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

MRGPRX2 agonist; also non-competitive nAChR antagonist

Product Description

PAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC₅₀ = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

Product Specifications for PAMP-20 (human)

Molecular Weight

2460.87

Formula

C₁₁₂H₁₇₈N₃₆O₂₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

150238-87-2

PubChem ID

71311703

InChI Key

PIRWNASAJNPKHT-SHZATDIYSA-N

SMILES

[H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Kamohara Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun, 2005 PMID: 15823563
Mahata Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension 1998 PMID: 9822452

Product Documents for PAMP-20 (human)

Certificate of Analysis

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Product Specific Notices for PAMP-20 (human)

For research use only

Citations for PAMP-20 (human)

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