para-Nitroblebbistatin

Key Product Details

Product Description

para

-Nitroblebbistatin is a selective inhibitor of Myosin II ATPase activity (IC₅₀ = 15 μM). It is a non-fluorescent, photostable, non-cytotoxic and non-phototoxic derivative of (±)-Blebbistatin (Cat. No. 1760).

(S)-(-)-Blebbistatin (Cat. No. 1852) also available.

Product Specifications for para-Nitroblebbistatin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for para-Nitroblebbistatin

The following data is based on the product molecular weight 337.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.93 mL	29.64 mL	59.29 mL
2.5 mM	1.19 mL	5.93 mL	11.86 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
25 mM	0.12 mL	0.59 mL	1.19 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Képiró para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor Angew.Chem Int.Ed.Engl. 2011 PMID: 24954740
• Värkuti A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci.Rep. 2016 PMID: 27241904
• Gollapudi Two classes of myosin inhibitors, para-nitroblebbistatin and mavacamten, stabilize β-cardiac myosin in different structural and functional states. J.Mol.Biol. 2021 PMID: 34627791

Product Documents for para-Nitroblebbistatin