PAWR / PAR4 Antibody - BSA Free

Novus Biologicals | Catalog # NB600-219

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all PAWR / PAR4 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to the N-terminal sequence (MATGGYRTSSGLGGS) and C-terminal sequence (QENKTLLKVVGQLTR) of human PAR4.

Reactivity Notes

Human. Other species have not been tested.

Localization

Cytoplasm. Nucleus. Note: Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML n

Specificity

PAR4

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

13 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Applications for PAWR / PAR4 Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:500 -1:1000
Application Notes
This antibody is useful for Western blot.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PAWR / PAR4

The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. Par-4 (for prostate apoptosis response) is a WT1-interacting protein that also functions as a transcriptional repressor. Par-4 contains a putative leucine zipper domain and is specifically upregulated during apoptosis of prostate cells.

Alternate Names

Par-4, PAR4prostate apoptosis response protein 4, PRKC apoptosis WT1 regulator protein, PRKC, apoptosis, WT1, regulator, Prostate apoptosis response 4 protein, prostate apoptosis response protein PAR-4, transcriptional repressor PAR4, WT1-interacting protein

Entrez Gene IDs

5074 (Human)

Gene Symbol

PAWR

UniProt

Q86TG5 (Human)

Additional PAWR / PAR4 Products

Product Documents for PAWR / PAR4 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for PAWR / PAR4 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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