Chemical Name: 6,11-Dihydrobenzothiopyrano[4,3-b]indole
Biological Activity Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at +4°C
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