Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki
= 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50
= 0.54 μ
M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo
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Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells.
Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, Mullarky IK
Prostaglandins Other Lipid Mediat., 2005;76(1):19-34.
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.
Sendobry et al.
A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.
Bocan et al.
The citations listed below are publications that use Tocris products. Selected citations for PD 146176 include:
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