PD 184352

Tocris Bioscience | Catalog # 4237

Selective MEK inhibitor
Tocris Bioscience

Key Product Details

Description

Selective MEK inhibitor

Alternative Names

CI-1040
View all MEK Inhibitors »

Product Description

PD 184352 is a selective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PD 184352

Molecular Weight

478.66

Formula

C17H14ClF2IN2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide

CAS Number

212631-79-3

PubChem ID

6918454

InChI Key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

SMILES

FC1=C(NC2=CC=C(I)C=C2Cl)C(C(NOCC3CC3)=O)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.87 100
Ethanol 11.97 25

Preparing Stock Solutions for PD 184352

The following data is based on the product molecular weight 478.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.45 mL 20.89 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
10 mM 0.21 mL 1.04 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for PD 184352

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 184352

For research use only

Customer Reviews for PD 184352 (1)

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  • The role of ERK pathway in LPA induced pro-inflammatory phenotype in microglia cells
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary murine microglia cells
    Verified Customer | Posted 06/08/2019
    The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. The effect of PD1843452 was more prominent in slightly inhibiting the expression of pp65.
    PD 184352 4237

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