PD 184352

Catalog # Availability Size / Price Qty
4237/10
4237/50
PD 184352 | CAS No. 212631-79-3 | MEK Inhibitors
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Description: Selective MEK inhibitor
Alternative Names: CI-1040

Chemical Name: 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide

Product Details
Citations (3)
Reviews (1)

Biological Activity

Selective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

Technical Data

M.Wt:
478.66
Formula:
C17H14ClF2IN2O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store at +4°C
CAS No:
212631-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PD 184352

The citations listed below are publications that use Tocris products. Selected citations for PD 184352 include:

3 Citations: Showing 1 - 3

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The role of ERK pathway in LPA induced pro-inflammatory phenotype in microglia cells
By Joanna Plastira on 06/08/2019
Species: Mouse

The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. The effect of PD1843452 was more prominent in slightly inhibiting the expression of pp65.


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