PD 184352

Catalog # Availability Size / Price Qty
4237/10
4237/50
PD 184352 | CAS No. 212631-79-3 | MEK Inhibitors
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Description: Selective MEK inhibitor
Alternative Names: CI-1040

Chemical Name: 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide

Product Details
Citations (3)
Reviews

Biological Activity

PD 184352 is a selective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

Technical Data

M.Wt:
478.66
Formula:
C17H14ClF2IN2O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store at +4°C
CAS No:
212631-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PD 184352

The citations listed below are publications that use Tocris products. Selected citations for PD 184352 include:

3 Citations: Showing 1 - 3

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