Chemical Name: 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide
Biological ActivitySelective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK).
Allen et al.
BRAF mutation predicts sensitivity to MEK inhibition.
Solit et al.
Enhancement of the therapeutic efficacy of Tax. by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants.
McDaid et al.
Cancer Res., 2005;65:2854
Citations for PD 184352
The citations listed below are publications that use Tocris products. Selected citations for PD 184352 include:
3 Citations: Showing 1 - 3
Activation of protein synthesis in mouse uterine epithelial cells by OE-17β is mediated by a PKC-ERK1/2-mTOR signaling pathway.
Authors: Wang Et al.
BMC Res Notes 2015;112:E1382
Central role for protein kinase C in oxyt. and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells.
Authors: Wouters Et al.
Genes Cancer 2014;7:357
miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling.
Authors: Martin Et al.
J Exp Bot 2014;5:353
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PD 184352
Average Rating: 5 (Based on 1 Review)
Have you used PD 184352?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. The effect of PD1843452 was more prominent in slightly inhibiting the expression of pp65.