Chemical Name: 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide
Biological ActivityPD 184352 is a selective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK).
Allen et al.
BRAF mutation predicts sensitivity to MEK inhibition.
Solit et al.
Enhancement of the therapeutic efficacy of Tax. by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants.
McDaid et al.
Cancer Res., 2005;65:2854
Citations for PD 184352
The citations listed below are publications that use Tocris products. Selected citations for PD 184352 include:
3 Citations: Showing 1 - 3
Activation of protein synthesis in mouse uterine epithelial cells by OE-17β is mediated by a PKC-ERK1/2-mTOR signaling pathway.
Authors: Wang Et al.
BMC Res Notes 2015;112:E1382
Central role for protein kinase C in oxyt. and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells.
Authors: Wouters Et al.
Genes Cancer 2014;7:357
miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling.
Authors: Martin Et al.
J Exp Bot 2014;5:353
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The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. The effect of PD1843452 was more prominent in slightly inhibiting the expression of pp65.