Catalog Number: 1190
Biological Activity
Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).
Technical Data
  • M.Wt:
    685.89
  • Formula:
    C34H63N5O9
  • Sequence:
    VVA

    (Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)

  • Solubility:
    Soluble to 1 mg/ml in ethanol with gentle warming
  • Storage:
    Desiccate at -20°C
  • CAS No:
    26305-03-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Mode of inhibition of acid proteases by pepstatin.
    Marciniszyn et al.
    J.Biol.Chem., 1976;251:7088
  3. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.
    Sato et al.
    Cancer Res., 2007;67:9677
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pepstatin A include:

1 Citations: Showing 1 - 1

  1. WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma.
    Authors: Tsai Et al.
    J Neurosci 2013;4:e792

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