Catalog Number: 4545
Chemical Name: (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
Biological Activity
Inhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable.
Technical Data
  • M.Wt:
    342.43
  • Formula:
    C17H30N2O5
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    88321-09-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy.
    Tanada et al.
    Autophagy, 2005;1:84
  2. Inhibition of cysteine proteinases in lysosomes and whole cells.
    Wilcox and Mason
    Biochem.J., 1992;285:495
  3. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.
    Sato et al.
    Cancer Res., 2007;67:9677
  4. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer.
    Kim et al.
    Autophagy, 2008;4:659

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