Chemical Name: (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
Biological ActivityInhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable. Also inhibits entry of SARS-Cov-2 (COVID-19) into Caco-2 and Vero cells in combination with Camostat mesylate (Cat.No. 3193) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer.
Kim et al.
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.
Sato et al.
Cancer Res., 2007;67:9677
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy.
Tanada et al.
Inhibition of cysteine proteinases in lysosomes and whole cells.
Wilcox and Mason
SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor.
Hoffmann et al.
Citations for E 64d
The citations listed below are publications that use Tocris products. Selected citations for E 64d include:
2 Citations: Showing 1 - 2
TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.
Authors: Zhang Et al.
Sci Rep 2017;7:3158
Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.
Authors: Guerroue Et al.
Mol Cell 2017;68:786
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