PF 04418948

  ( 3 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4818
Chemical Name:1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
Technical Data
  • M.Wt:
    409.41
  • Formula:
    C23H20FNO5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1078166-57-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 04418948 include:

3 Citations: Showing 1 - 3
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  1. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition.
    Authors: Liu Et al.
    Mol Cell Endocrinol  2016;424:118
  2. Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice
    Authors: Liu Et al.
    PLoS One  2016;11:e0165200
  3. Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition.
    Authors: Wang Et al.
    Sci Signal  2015;8

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Average Rating: 5 (Based on 1 review)

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