PF 04418948

Catalog # Availability Size / Price Qty
4818/10
4818/50
Prostanoid Receptor Antagonists Small Molecule
1 Image
Description: Potent and selective EP2 receptor antagonist

Chemical Name: 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

Purity: ≥99%

Product Details
Citations (5)
Supplemental Products
Reviews (1)

Biological Activity

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).

Technical Data

M.Wt:
409.41
Formula:
C23H20FNO5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1078166-57-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 04418948

The citations listed below are publications that use Tocris products. Selected citations for PF 04418948 include:

5 Citations: Showing 1 - 5

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PF 04418948
By Anonymous on 05/31/2017

in vivo survival assay


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