Catalog Number: 4281
Chemical Name: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
Biological Activity
Selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
    396.27
  • Formula:
    C17H18ClN5O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1391052-28-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Selective inhibition of casein kinase 1ε minimally alters circadian clock period.
    Walton et al.
    J.Pharmacol.Exp.Ther., 2009;330:430
  2. Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro.
    Etchegaray et al.
    PLoS One, 2010;5:e10303
  3. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
    Meng et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:15240
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 4800567 hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis.
    Authors: Oren Et al.
    Mol Biol Cell 2015;5:11418
  2. Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
    Authors: Cheong Et al.
    J Clin Invest 2015;125:1401
  3. CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
    Authors: Zemp Et al.
    J Cell Sci 2014;127:1242

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