PF 4800567 hydrochloride
Chemical Name: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
Biological ActivityPF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective inhibition of casein kinase 1ε minimally alters circadian clock period.
Walton et al.
Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro.
Etchegaray et al.
PLoS One, 2010;5:e10303
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Meng et al.
Citations for PF 4800567 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PF 4800567 hydrochloride include:
4 Citations: Showing 1 - 4
Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis.
Authors: Oren Et al.
Mol Biol Cell 2015;5:11418
Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
Authors: Cheong Et al.
J Clin Invest 2015;125:1401
CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
Authors: Zemp Et al.
J Cell Sci 2014;127:1242
Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra.
Authors: Zhang Et al.
Curr Biol 2013;23:1863
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