7 nAChR agonist that displays selectivity over α
2 and 5-HT3
receptors. Positively influences sensory gating and memory in in vivo
models of schizophrenia. Orally active and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and st
Wishka et al.
Allosteric modulators of the α7 nicotinic acetylcholine receptor.
Faghih et al.
Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
Acker et al.
The citations listed below are publications that use Tocris products. Selected citations for PHA 543613 hydrochloride include:
Showing Results 1 - 2 of 2