PHA 543613 hydrochloride

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PHA 543613 hydrochloride | CAS No. 1586767-92-1 | Nicotinic (a7) Receptor Agonists
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Description: Potent and selective α7 nAChR agonist

Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (7)
Supplemental Products
Reviews (1)

Biological Activity

PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.

Technical Data

Soluble to 100 mM in water and to 25 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Allosteric modulators of the α7 nicotinic acetylcholine receptor.
    Faghih et al.
    J.Med.Chem., 2008;51:701
  2. Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
    Acker et al.
    Bioorg.Med.Chem.Letts., 2008;18:3611
  3. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and st
    Wishka et al.
    J.Med.Chem., 2006;49:4425

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Citations for PHA 543613 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PHA 543613 hydrochloride include:

7 Citations: Showing 1 - 7


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Cognitive enhancer effect of PHA 543613 in rat behavioral tests
By Zsolt Bali on 02/14/2018
Application: Species: Rat

We used PHA 543613 in behavioral pharmacology experiments and tested its cognitive enhancer effect. PHA 543613 was found effective in different behavioral paradigms, and in different models of cognitive impairment. For instance, PHA 543613 dose-dependently reversed scopolamine induced transient amnesia in the spontaneous alternation (t-maze) task of rats.

PMID: 25447295

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