PHA 543613 hydrochloride

Tocris Bioscience | Catalog # 3092

Potent and selective α7 nAChR agonist
Tocris Bioscience

Key Product Details

Description

Potent and selective α7 nAChR agonist
View all Nicotinic (a7) Receptor Agonists »

Product Description

PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PHA 543613 hydrochloride

Molecular Weight

307.78

Formula

C15H17N3O2.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

CAS Number

1586767-92-1

PubChem ID

56972222

InChI Key

YMTPSZUBRSEWNY-ZOWNYOTGSA-N

SMILES

O=C(C2=NC=C(OC=C3)C3=C2)N[C@@H]1C4CCN(CC4)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.78 100
DMSO 7.69 25

Preparing Stock Solutions for PHA 543613 hydrochloride

The following data is based on the product molecular weight 307.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.25 mL 32.49 mL
5 mM 0.65 mL 3.25 mL 6.50 mL
10 mM 0.32 mL 1.62 mL 3.25 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Documents for PHA 543613 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PHA 543613 hydrochloride

For research use only

Citations for PHA 543613 hydrochloride

Customer Reviews for PHA 543613 hydrochloride (1)

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  • Cognitive enhancer effect of PHA 543613 in rat behavioral tests
    Name: Zsolt Bali
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 02/14/2018
    Sometimes we experienced poor solubility in physiological saline. Slight warming and ultrasonics might help.
    We used PHA 543613 in behavioral pharmacology experiments and tested its cognitive enhancer effect. PHA 543613 was found effective in different behavioral paradigms, and in different models of cognitive impairment. For instance, PHA 543613 dose-dependently reversed scopolamine induced transient amnesia in the spontaneous alternation (t-maze) task of rats.

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