PHA 543613 hydrochloride

Catalog # Availability Size / Price Qty
3092/10
PHA 543613 hydrochloride | CAS No. 1586767-92-1 | Nicotinic (a7) Receptor Agonists
1 Image
Description: Potent and selective α7 nAChR agonist

Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (7)
Supplemental Products
Reviews (1)

Biological Activity

Potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.

Technical Data

M.Wt:
307.78
Formula:
C15H17N3O2.HCl
Solubility:
Soluble to 100 mM in water and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1586767-92-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and st
    Wishka et al.
    J.Med.Chem., 2006;49:4425
  2. Allosteric modulators of the α7 nicotinic acetylcholine receptor.
    Faghih et al.
    J.Med.Chem., 2008;51:701
  3. Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
    Acker et al.
    Bioorg.Med.Chem.Letts., 2008;18:3611

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for PHA 543613 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PHA 543613 hydrochloride include:

7 Citations: Showing 1 - 7

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for PHA 543613 hydrochloride

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used PHA 543613 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Cognitive enhancer effect of PHA 543613 in rat behavioral tests
By Zsolt Bali on 02/14/2018
Species: Rat

We used PHA 543613 in behavioral pharmacology experiments and tested its cognitive enhancer effect. PHA 543613 was found effective in different behavioral paradigms, and in different models of cognitive impairment. For instance, PHA 543613 dose-dependently reversed scopolamine induced transient amnesia in the spontaneous alternation (t-maze) task of rats.

PMID: 25447295

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.