PHA 543613 hydrochloride (CAS 478149-53-0): R&D Systems
Catalog Number: 3092
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
Biological Activity
Potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.
Technical Data
  • M.Wt:
    307.78
  • Formula:
    C15H17N3O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    478149-53-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and st
    Wishka et al.
    J.Med.Chem., 2006;49:4425
  2. Allosteric modulators of the α7 nicotinic acetylcholine receptor.
    Faghih et al.
    J.Med.Chem., 2008;51:701
  3. Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
    Acker et al.
    Bioorg.Med.Chem.Letts., 2008;18:3611
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PHA 543613 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.
    Authors: Foucault-Fruchard
    Neuroscience 2017;356:52
  2. Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.
    Authors: Sérriàre Et al.
    Cell Death Differ 2015;2:61
  3. The α7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes.
    Authors: Macpherson Et al.
    Front Med (Lausanne) 2014;63:557

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