PHA 543613 hydrochloride

  ( 4 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3092
Chemical Name:N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.
Technical Data
  • M.Wt:
    307.78
  • Formula:
    C15H17N3O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    478149-53-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PHA 543613 hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.
    Authors: Foucault-Fruchard
    Neuroscience  2017;356:52
  2. Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.
    Authors: Sérriàre Et al.
    Cell Death Differ  2015;2:61
  3. Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models.
    Authors: Bali Et al.
    Behav Brain Res  2015;278:404
  4. The α7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes.
    Authors: Macpherson Et al.
    Front Med (Lausanne)  2014;63:557

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Average Rating: 5 (Based on 1 review)

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  Rat Zsolt Bali 02/14/2018
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Summary

Species Rat
Pub Med ID 25447295

Other Experimental Details

Other Experimental Details Sometimes we experienced poor solubility in physiological saline. Slight warming and ultrasonics might help.

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