Picrotoxin

Tocris Bioscience | Catalog # 1128

GABAA antagonist
Tocris Bioscience

Key Product Details

Description

GABAA antagonist
View all GABA-A Receptor Antagonists »

Product Description

Picrotoxin is a GABAA receptor antagonist; potent CNS stimulant.

Product Specifications for Picrotoxin

Molecular Weight

602.59

Formula

C30H34O13

Storage

Store at RT

Purity

≥97% (HPLC)

CAS Number

124-87-8

PubChem ID

6473767

InChI Key

VJKUPQSHOVKBCO-ZYMHLGHZSA-N

SMILES

[H][C@@]12OC([C@@](C1(C(C)=C)[H])([C@@]3(C[C@H]4O[C@]45C(O[C@]2([C@]35C)[H])=O)O)[H])=O.[H][C@@]67OC([C@@](C6(C(C)(O)C)[H])([C@@]8(C[C@H]9O[C@]9%10C(O[C@]7([C@]8%10C)[H])=O)O)[H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.05 20
Ethanol 30.13 50 with gentle warming

Preparing Stock Solutions for Picrotoxin

The following data is based on the product molecular weight 602.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.32 mL 16.60 mL 33.19 mL
2.5 mM 0.66 mL 3.32 mL 6.64 mL
5 mM 0.33 mL 1.66 mL 3.32 mL
25 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 1297 publications citing the usage of this product.

Product Documents for Picrotoxin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Picrotoxin

For research use only

Related Research Areas

GABA Receptors

Customer Reviews for Picrotoxin (4)

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  • Works as GABA-A receptor antagonist.
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 06/01/2020
    Picrotoxin stock was prepared in DMSO and diluted with ACSF to 25 micromolar concentration. Bath application of Picrotoxin blocked evoked inhibitory postsynaptic currents in an ex-vivo slice preparation.
  • Picrotoxin blocks single-channel openings of GABA-A receptor
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 07/21/2019
    20 microM Picrotoxin concentration was used to block GABA-A receptor openings in nucleated cell membrane patches. Full block was achieved in ~30 seconds after application. Picture: GABA-A receptor openings under control conditions (top three traces) and after application of Picrotoxin (bottom trace).
    Picrotoxin 1128
  • silence GABA activity
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: cortical neurons
    Verified Customer | Posted 10/26/2018
    Used to block GABA activity in 16 day old cortical neurons. Effective at 10 micromolar concentration. Incubated for 30 minutes before measuring bursts.
    Picrotoxin 1128
  • GABA blocker
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 10/02/2018
    Used for electrophysiology to block GABA currents. Works as expected

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