Picrotoxin

Catalog # Availability Size / Price Qty
1128/1G
Picrotoxin | CAS No. 124-87-8 | GABA-A Receptor Antagonists
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Description: GABAA antagonist
Product Details
Citations (125)
Supplemental Products
Reviews (4)

Biological Activity

GABAA receptor antagonist; potent CNS stimulant.

Technical Data

M.Wt:
602.59
Formula:
C30H34O13
Solubility:
Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
124-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Picrotoxin

The citations listed below are publications that use Tocris products. Selected citations for Picrotoxin include:

125 Citations: Showing 1 - 10

  1. Feeding induced by cannabinoids is mediated independently of the melanocortin system.
    Authors: Sinnayah Et al.
    J Neurosci  ;3:e2202
  2. Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.
    Authors: Bhandage Et al.
    Front Cell Infect Microbiol  2019;9:73
  3. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
    Authors: Li Et al.
    Elife  2019;8
  4. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
    Authors: Spoljaric Et al.
    Cell Rep  2019;26:1073
  5. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.
    Authors: Franchini Et al.
    iScience  2019;19:927
  6. Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion.
    Authors: Song Et al.
    Front Cell Neurosci  2019;13:111
  7. Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice.
    Authors: Yu Et al.
    Mol Brain  2019;12:29
  8. The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
    Authors: Incontro
    Nat Commun  2018;9:2069
  9. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
    Authors: Wall Et al.
    Neuron  2018;98:1124
  10. DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
    Authors: Tozzi
    Cell Death Dis  2018;9(2):204
  11. Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
    Authors: Chang and Higley
    Physiol Rep  2018;6:e13747
  12. Genetic identification of leptin neural circuits in energy and glucose homeostases.
    Authors: Xu Et al.
    Nature  2018;556:505
  13. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
    Authors: Purkey Et al.
    Cell Rep  2018;25:974
  14. The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
    Authors: McKay Et al.
    Cell Rep  2018;25:841
  15. DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
    Authors: Cai and Ford
    Cell Rep  2018;25:3148
  16. Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.
    Authors: Sancho and Bloodgood
    Cell Rep  2018;24:2075
  17. Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
    Authors: O'Neill and Sylantyev
    Exp Biol Med (Maywood)  2018;243:1046
  18. Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release.
    Authors: Rhijn Et al.
    Brain Struct Funct  2018;223:4211
  19. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
    Authors: Beas Et al.
    Nat Neurosci  2018;21:963
  20. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
    Authors: Fan Et al.
    Nat Methods  2018;15:823
  21. IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
    Authors: Liu Et al.
    Neuron  2017;95:106
  22. Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
    Authors: Sando Et al.
    Neuron  2017;94:312
  23. A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
    Authors: Li Et al.
    Neuron  2017;94:1155
  24. Post-Inhibitory Rebound Spikes in Rat Medial Entorhinal Layer II/III Principal Cells: In Vivo, In Vitro, and Computational Modeling Characterization.
    Authors: Ferrante Et al.
    Cereb Cortex  2017;27:2111
  25. Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2.
    Authors: Gioia Et al.
    Front Neurosci  2017;11:424
  26. Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
    Authors: Pan Et al.
    Neuron  2016;6:28137
  27. Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding.
    Authors: Chen Et al.
    Elife  2016;5
  28. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens DA D1 Receptor Neurons.
    Authors: Beckley Et al.
    J Neurosci  2016;36:701
  29. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus.
    Authors: Zhang Et al.
    Cell Res  2016;26:728
  30. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
    Authors: Dennis Et al.
    J Neurosci  2016;26:414
  31. SHANK3 controls maturation of social reward circuits in the VTA.
    Authors: Bariselli Et al.
    Nat Neurosci  2016;19:926
  32. A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors.
    Authors: Li Et al.
    Cell  2016;167:60
  33. Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.
    Authors: Ho Et al.
    Methods  2016;101:113
  34. NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
    Authors: Ghosh Et al.
    Neural Plast  2015;9:450
  35. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    Physiol Rep  2015;9:290
  36. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  37. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.
    Authors: Quintana Et al.
    Front Cell Neurosci  2015;593:4373
  38. Hierarchical organization of long-range circuits in the olfactory cortices.
    Authors: Yang and Sun
    Cereb Cortex  2015;3
  39. Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum.
    Authors: Dobson and Bellamy
    Sci Rep  2015;2015:602356
  40. Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics.
    Authors: Nagel Et al.
    Nat Neurosci  2015;18:56
  41. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Pharmacol Exp Ther  2015;10:e0125974
  42. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  43. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  44. Excitatory drive onto DArgic neurons in the rostral linear nucleus is enhanced by NE in an α1 adrenergic receptor-dependent manner.
    Authors: Williams Et al.
    Neuropharmacology  2014;86:116
  45. A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release.
    Authors: Tani Et al.
    Neuron  2014;81:888
  46. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis  2014;5:e1523
  47. The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility.
    Authors: Eales Et al.
    Nat Commun  2014;5:4701
  48. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    PLoS One  2014;3:282
  49. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA DA neurons.
    Authors: Vashchinkina Et al.
    Neuropsychopharmacology  2014;39:727
  50. Gap junction networks can generate both ripple-like and fast ripple-like oscillations.
    Authors: Simon Et al.
    Eur J Neurosci  2014;39:46
  51. Activity-dependent regulation of dendritic complexity by semaphorin 3A through Farp1.
    Authors: Cheadle and Biederer
    J Biol Chem  2014;34:7999
  52. Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex.
    Authors: Easton Et al.
    J Neurosci  2014;34:3854
  53. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    J Neurosci  2014;12:47
  54. Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit.
    Authors: Neuser Et al.
    PLoS One  2013;8:e66497
  55. Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes.
    Authors: Rehak Et al.
    PLoS One  2013;8:e61844
  56. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    PLoS One  2013;8:e61787
  57. Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic DA neurons.
    Authors: Beckley Et al.
    J Neurosci  2013;33:804
  58. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
    Authors: Caiati Et al.
    J Neurosci  2013;33:2973
  59. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.
    Authors: Brady Et al.
    Cell Metab  2013;33:1062
  60. SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.
    Authors: Mameza Et al.
    J Neurosci  2013;288:26697
  61. Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
    Authors: Hou and Yu
    J Biol Chem  2013;288:2501
  62. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation.
    Authors: Chanda Et al.
    Cell Commun Signal  2013;110:16622
  63. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
    Authors: Klug Et al.
    PLoS One  2012;7:e45323
  64. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One  2012;7:e36874
  65. Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.
    Authors: Yoon Et al.
    Mol Brain  2012;5:40
  66. Simulated GABA synaptic input and L-type calcium channels form functional microdomains in hypothalamic gonadotropin-releasing hormone neurons.
    Authors: Hemond Et al.
    J Neurosci  2012;32:8756
  67. Activity-dependent regulation of inhibition via GAD67.
    Authors: Lau and Murthy
    J Physiol  2012;32:8521
  68. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
    Authors: Hulme Et al.
    J Neurosci  2012;32:6785
  69. Ventral tegmental area glutamate neurons: electrophysiological properties and projections.
    Authors: Hnasko Et al.
    J Neurosci  2012;32:15076
  70. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci  2012;32:13889
  71. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  72. NMDA receptors and BAX are essential for Aβ impairment of LTP.
    Authors: Olsen and Sheng
    Sci Rep  2012;2:225
  73. Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits.
    Authors: Lugo Et al.
    Learn Mem  2012;19:182
  74. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
    Authors: McKay Et al.
    Br J Pharmacol  2012;166:924
  75. Independent regulation of basal neurotransmitter release efficacy by variable Ca2+ influx and bouton size at small central synapses.
    Authors: Ermolyuk Et al.
    PLoS Biol  2012;10:e1001396
  76. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
    Authors: Wills Et al.
    Proc Natl Acad Sci U S A  2012;109:E278
  77. A critical role for GluN2B-containing NMDA receptors in cortical development and function.
    Authors: Wang Et al.
    Neuron  2011;72:789
  78. Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.
    Authors: Li Et al.
    PLoS One  2011;6:e26065
  79. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One  2011;6:e19155
  80. β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
    Authors: Nobis Et al.
    Biol Psychiatry  2011;69:1083
  81. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation.
    Authors: Lecrux Et al.
    J Neurosci  2011;31:9836
  82. Molecular determinants controlling NMDA receptor synaptic incorporation.
    Authors: Storey Et al.
    J Neurosci  2011;31:6311
  83. Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
    Authors: Mark Et al.
    J Neurosci  2011;31:4311
  84. Attenuating GABA(A) receptor signaling in DA neurons selectively enhances reward learning and alters risk preference in mice.
    Authors: Parker Et al.
    J Neurosci  2011;31:17103
  85. A diversity of synaptic filters are created by temporal summation of excitation and inhibition.
    Authors: George Et al.
    J Neurosci  2011;31:14721
  86. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
    Authors: Lazarevic Et al.
    Mol Pain  2011;31:10189
  87. An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
    Authors: Etherton Et al.
    EMBO J  2011;30:2908
  88. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci  2011;14:866
  89. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy.
    Authors: Paz Et al.
    J Biol Chem  2011;14:1167
  90. Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Authors: Lam Et al.
    Stem Cell Reports  2011;13:584
  91. Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning.
    Authors: Thompson and Perkel
    J Neurophysiol  2011;105:1159
  92. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron  2010;68:948
  93. Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo.
    Authors: Chen Et al.
    J Neurophysiol  2010;67:967
  94. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One  2010;5:e11962
  95. DA-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci  2010;30:2935
  96. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
    Authors: Lerner Et al.
    J Neurosci  2010;30:2160
  97. A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate.
    Authors: Nishino Et al.
    BMC Neurosci  2010;11:6
  98. Inhibitory role for GABA in autoimmune inflammation.
    Authors: Bhat Et al.
    Proc Natl Acad Sci U S A  2010;107:2580
  99. Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex.
    Authors: Kaneko Et al.
    Proc Natl Acad Sci U S A  2010;107:19026
  100. A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons.
    Authors: Lobb Et al.
    J Neurophysiol  2010;104:403
  101. Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
    Authors: Yeo Et al.
    Nat Neurosci  2009;29:14652
  102. PropF. inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.
    Authors: Shiratsuchi Et al.
    Am J Physiol Cell Physiol  2009;296:C1400
  103. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    J Neurosci  2009;284:8726
  104. PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons.
    Authors: Dixon Et al.
    J Neurosci  2009;284:14230
  105. alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis.
    Authors: Shields Et al.
    Neuroscience  2009;163:339
  106. Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV.
    Authors: Sun
    J Neurosci  2009;102:2955
  107. A presynaptic gain control mechanism fine-tunes olfactory behavior.
    Authors: Root Et al.
    Neuron  2008;59:311
  108. Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.
    Authors: Jüngling Et al.
    Neuron  2008;59:298
  109. Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
    Authors: Safiulina Et al.
    J Physiol  2008;586:5437
  110. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus.
    Authors: Chiu and Castillo
    Neuropharmacology  2008;54:68
  111. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
    Authors: Andäng Et al.
    Nature  2008;451:460
  112. Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders.
    Authors: McElligott
    Neuropsychopharmacology  2008;33:2313
  113. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  114. NMDA receptor blockade with Mem. attenuates white matter injury in a rat model of periventricular leukomalacia.
    Authors: Manning Et al.
    J Biol Chem  2008;28:6670
  115. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin.
    Authors: Frischknecht Et al.
    J Neurosci  2008;28:1568
  116. Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit.
    Authors: Brill and Huguenard
    PLoS One  2008;28:13918
  117. DA enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
    Authors: Kash Et al.
    J Neurosci  2008;28:13856
  118. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
    Authors: Soriano Et al.
    J Neurosci  2008;28:10696
  119. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
    Authors: Marsden Et al.
    J Neurosci  2007;27:14326
  120. Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
    Authors: Brager and Johnston
    J Neurosci  2007;27:13926
  121. Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe.
    Authors: Shang Et al.
    Cell  2007;128:601
  122. Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling.
    Authors: Inan Et al.
    J Neurosci  2006;26:4338
  123. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
    Authors: Kopp Et al.
    J Neurosci  2006;26:12456
  124. PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
    Authors: Ying and Goldstein
    Front Cell Neurosci  2005;1:2
  125. Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.
    Authors: Smith and Otis
    Proc Natl Acad Sci U S A  2005;102:14901

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Works as GABA-A receptor antagonist.
By Anonymous on 06/01/2020
Application: Species: Mouse

Picrotoxin stock was prepared in DMSO and diluted with ACSF to 25 micromolar concentration. Bath application of Picrotoxin blocked evoked inhibitory postsynaptic currents in an ex-vivo slice preparation.


Picrotoxin blocks single-channel openings of GABA-A receptor
By Anonymous on 07/21/2019
Application: Species: Rat

20 microM Picrotoxin concentration was used to block GABA-A receptor openings in nucleated cell membrane patches. Full block was achieved in ~30 seconds after application. Picture: GABA-A receptor openings under control conditions (top three traces) and after application of Picrotoxin (bottom trace).

PMID: 30205722

silence GABA activity
By Karthik krishnamurthy on 10/26/2018
Application: Species: Rat

Used to block GABA activity in 16 day old cortical neurons. Effective at 10 micromolar concentration. Incubated for 30 minutes before measuring bursts.


GABA blocker
By Anonymous on 10/02/2018
Application: Species: Rat

Used for electrophysiology to block GABA currents. Works as expected


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