Pioglitazone hydrochloride

Tocris Bioscience | Catalog # 4124

Selective PPARγ agonist; antidiabetic agent
Tocris Bioscience

Key Product Details

Description

Selective PPARγ agonist; antidiabetic agent
View all PPAR gamma Receptor Agonists »

Product Description

Pioglitazone hydrochloride is a selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat. No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.

Product Specifications for Pioglitazone hydrochloride

Molecular Weight

392.90

Formula

C19H20N2O3S.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride

CAS Number

112529-15-4

PubChem ID

60560

InChI Key

GHUUBYQTCDQWRA-UHFFFAOYSA-N

SMILES

O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.82 25

Preparing Stock Solutions for Pioglitazone hydrochloride

The following data is based on the product molecular weight 392.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.18 mL 50.90 mL 101.81 mL
1.25 mM 2.04 mL 10.18 mL 20.36 mL
2.5 mM 1.02 mL 5.09 mL 10.18 mL
12.5 mM 0.20 mL 1.02 mL 2.04 mL

Calculators

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Product Documents for Pioglitazone hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pioglitazone hydrochloride

For research use only

Citations for Pioglitazone hydrochloride

Customer Reviews for Pioglitazone hydrochloride (1)

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  • Pioglitazone hydrochloride promotes macrophage M2 polarization.
    Name: GAJANAN KATKAR
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Bone marrow derived macrophage
    Verified Customer | Posted 12/07/2019
    Pioglitazone hydrochloride promotes macrophage M2 polarization. To achieve this M0 macrophages BMDM (bone marrow-derived macrophages) stimulated with pioglitazone (5 µm) for 24 h.

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