Catalog Number: 4124
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Biological Activity
Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones.
    Willson et al.
    J.Med.Chem., 1996;39:665
  2. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
    Sakamoto et al.
    Biochem.Biophys.Res.Commun., 2000;278:704
  3. Pioglitazone: mechanism of action.
    Int.J.Clin.Pract.Suppl., 2001;121:13
  4. Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.
    Momose et al.
    J.Med.Chem., 2002;45:1518

The citations listed below are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:

Showing Results 1 - 3 of 3

  1. Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
    Authors: Thakran Et al.
    PLoS One
  2. Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.
    Authors: Byrne Et al.
    J Diabetes Res
  3. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
    Authors: Wahlang Et al.
    Toxicol Sci
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