Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Biological ActivitySelective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat.No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones.
Willson et al.
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as Ins sensitizers with antidiabetic activities.
Momose et al.
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglit.
Sakamoto et al.
The synergistic enhancement of cloning efficiency in individualized human pluripotent stem cells by peroxisome proliferative-activated receptor-γ (PPARγ) activation and Rho-associated kinase (ROCK) inhibition.
Kajabadi et al.
Citations for Pioglitazone hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:
5 Citations: Showing 1 - 5
Ponatinib treatment promotes arterial thrombosis and hyperactive platelets.
Authors: Merkulova Et al.
Blood Adv 2019;3:2312
Pioglit restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
Authors: Thakran Et al.
PLoS One 2015;56:177
Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.
Authors: Byrne Et al.
J Diabetes Res 2015;2015:752481
Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
Authors: Helmy Et al.
PLoS One 2015;10:e0142303
Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
Authors: Wahlang Et al.
Toxicol Sci 2014;140:283
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