Catalog Number: 4124
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Biological Activity
Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.
Technical Data
  • M.Wt:
    392.9
  • Formula:
    C19H20N2O3S.HCl
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    112529-15-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones.
    Willson et al.
    J.Med.Chem., 1996;39:665
  2. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
    Sakamoto et al.
    Biochem.Biophys.Res.Commun., 2000;278:704
  3. Pioglitazone: mechanism of action.
    Smith
    Int.J.Clin.Pract.Suppl., 2001;121:13
  4. Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.
    Momose et al.
    J.Med.Chem., 2002;45:1518
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
    Authors: Thakran Et al.
    PLoS One 2015;56:177
  2. Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.
    Authors: Byrne Et al.
    J Diabetes Res 2015;2015:752481
  3. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
    Authors: Wahlang Et al.
    Toxicol Sci 2014;140:283

Have you used Pioglitazone hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information