Selective p160ROCK inhibitor (Ki
values are 0.14, 26, 25 and > 250 μ
M for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50
= 600 nM). Smooth muscle relaxant and orally active in vivo
. Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.