Y-27632 dihydrochloride

  ( 145 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1254
Chemical Name:trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Product Details
Citations (145)
Reviews
Biological Activity
Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells and iPSC-BMECs undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
Technical Data
  • M.Wt:
    320.26
  • Formula:
    C14H21N3O.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    129830-38-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Y-27632 dihydrochloride include:

145 Citations: Showing 1 - 10
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  1. Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors.
    Authors: Bantounas Et al.
    Stem Cell Reports  2018;10:766
  2. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
    Authors: Rath Et al.
    EMBO Mol Med  2017;9:198
  3. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.
    Authors: Benedicto
    Nat Commun  2017;8:15374
  4. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  5. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts.
    Authors: Bonan Et al.
    Oncotarget  2017;8:1304
  6. A pluripotent stem cell-based model for post-implantation human amniotic sac development.
    Authors: Shao
    Nat Commun  2017;8(1):208
  7. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell.  2017;31:399
  8. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  9. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
    Authors: Lee Et al.
    Cell Stem Cell  2017;21:179
  10. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  11. Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.
    Authors: Hall
    PLoS Genet  2017;13(2):e1006610
  12. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.
    Authors: Shi
    Mol Brain  2017;10(1):38
  13. Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids
    Authors: Jardé Et al.
    Nature Communications  2016;7:13207
  14. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.
    Authors: Guye Et al.
    Sci Rep  2016;7:10243
  15. Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics.
    Authors: Kellner Et al.
    Hippocampus  2016;6:816
  16. Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
    Authors: Borgs Et al.
    Scientific Reports  2016;6:33377
  17. Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
    Authors: Koopmans Et al.
    Sci Rep  2016;6:30676
  18. Tumor-induced remote ECM network orientation steers angiogenesis.
    Authors: Balcioglu Et al.
    Development  2016;6:22580
  19. Local mechanical forces promote polarized junctional assembly and axis elongation in Drosophila.
    Authors: Yu and Fernandez-Gonzalez
    Elife  2016;5
  20. ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
    Authors: Rath Et al.
    Sci Data  2016;3:160101
  21. Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization.
    Authors: Hien Et al.
    J Biol Chem  2016;291:3552
  22. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  23. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  24. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.
    Authors: Foulke-Abel Et al.
    Nat Commun  2016;150:638
  25. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using humanpluripotent stem cells.
    Authors: Palpant Et al.
    Nature Protocols  2016;12:15
  26. Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro.
    Authors: Chal Et al.
    Nat.Protoc.  2016;11:1833
  27. Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair.
    Authors: Fernandes Et al.
    Bone Res  2015;NULL
  28. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  29. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Vis  2015;6:8896
  30. A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
    Authors: Abraham Et al.
    Stem Cell Reports  2015;6:7286
  31. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Authors: Edri Et al.
    Nat Commun  2015;6:6500
  32. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    Brain  2015;6:6364
  33. A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement.
    Authors: Luzzani Et al.
    Int J Cancer  2015;6:6
  34. Cloning-free CRISPR.
    Authors: Arbab Et al.
    Cell  2015;5:908
  35. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.
    Authors: Lee Et al.
    Sci Rep  2015;5:11817
  36. Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices.
    Authors: Gjorevski Et al.
    Sci Rep  2015;5:11458
  37. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.
    Authors: Romero Et al.
    Elife  2015;4:e07103
  38. Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin.
    Authors: Höfner Et al.
    PLoS One  2015;4:503
  39. Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.
    Authors: Lachmann Et al.
    Nat Commun  2015;4:282
  40. Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation.
    Authors: Maharam Et al.
    Stem Cell Res Ther  2015;3:15015
  41. Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
    Authors: Morizane Et al.
    Nat Commun  2015;33:1193
  42. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.
    Authors: Lee Et al.
    Toxicol Sci  2015;290:14740
  43. Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632.
    Authors: Su Et al.
    PLoS Comput Biol  2015;21:633
  44. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
    Authors: Pattabiraman Et al.
    Autophagy  2015;185:496
  45. Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
    Authors: Vergara Et al.
    J Biol Chem  2015;16:2174
  46. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  47. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.
    Authors: Madsen Et al.
    EMBO Rep  2015;16:1394
  48. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
    Authors: Ruprecht Et al.
    Int J Mol Sci  2015;160:673
  49. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Int J Nanomedicine  2015;142:3166
  50. Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells.
    Authors: Tyson Et al.
    Stem Cells  2015;142:1267
  51. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  52. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    Stem Cell Reports  2015;136:E219
  53. The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions.
    Authors: Balcioglu Et al.
    Nat Biotechnol  2015;128:1316
  54. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Stem Cell Reports  2015;11:e1004453
  55. Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States.
    Authors: Chen Et al.
    PLoS One  2015;10:e0142554
  56. The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures.
    Authors: Davies Et al.
    PLoS One  2015;10:e0138531
  57. Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition.
    Authors: Serra Et al.
    PLoS One  2015;10:e0133875
  58. Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.
    Authors: Härmä Et al.
    Stem Cell Reports  2015;10:e0126111
  59. Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation.
    Authors: Tai Et al.
    Nat Commun  2015;10:5881
  60. Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs.
    Authors: Wile Et al.
    Nat Protoc  2014;9:2411
  61. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
    Authors: Moon Et al.
    Mucosal Immunol  2014;7:818
  62. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    Korean J Physiol Pharmacol  2014;5:5732
  63. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
    Authors: Orgaz Et al.
    Nat Commun  2014;5:4255
  64. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.
    Authors: Mich Et al.
    Elife  2014;3:e02669
  65. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton Et al.
    Stem Cell Reports  2014;3:516
  66. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis.
    Authors: Dickover Et al.
    Dev Biol  2014;389:182
  67. Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.
    Authors: Kirschstein Et al.
    Acta Pharmacol Sin  2014;35:74
  68. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  69. Cryopreservation of human pluripotent stem cells in defined medium.
    Authors: Liu and Chen
    Curr Protoc Stem Cell Biol  2014;31:1C.17.1
  70. Generation of GFP Reporter Human Induced Pluripotent Stem Cells Using AAVS1 Safe Harbor Transcription Activator-Like Effector Nuclease.
    Authors: Luo Et al.
    Curr Protoc Stem Cell Biol  2014;29:5A.7.1
  71. Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption.
    Authors: Pavlov Et al.
    J Biol Chem  2014;289:28651
  72. GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.
    Authors: Keimpema Et al.
    Cereb Cortex  2014;24:3277
  73. Competition between human cells by entosis.
    Authors: Sun Et al.
    Cell Res  2014;24:1299
  74. Induction of entosis by epithelial cadherin expression.
    Authors: Sun Et al.
    Cell Res  2014;24:1288
  75. Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.
    Authors: McNary Et al.
    Tissue Eng Part A  2014;20:921
  76. An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate.
    Authors: Williams Et al.
    Br J Pharmacol  2014;171:4902
  77. A high-throughput screen for teratogens using human pluripotent stem cells.
    Authors: Kameoka Et al.
    J Biomol Screen  2014;137:76
  78. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    Circ Res  2014;111:18126
  79. The role of mechanical force and ROS in integrin-dependent signals.
    Authors: Zeller Et al.
    PLoS One  2013;8:e64897
  80. Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.
    Authors: Barthwal Et al.
    PLoS One  2013;8:e58054
  81. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
    Authors: Matsumoto Et al.
    Orphanet J Rare Dis  2013;8:190
  82. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions.
    Authors: Lian Et al.
    Nat Protoc  2013;8:162
  83. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front Cell Neurosci  2013;6:64
  84. Activation of β 1 but not β 3 integrin increases cell traction forces.
    Authors: Lin Et al.
    J Neurosci  2013;587:763
  85. Generation of integration-free and region-specific neural progenitors from primate fibroblasts.
    Authors: Lu Et al.
    Curr Biol  2013;3:1580
  86. PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.
    Authors: Zhu and Nelson
    Cell  2013;379:235
  87. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Cell Biochem  2013;33:11361
  88. mTOR regulates phagosome and entotic vacuole fission.
    Authors: Krajcovic Et al.
    Mol Biol Cell  2013;24:3736
  89. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Stem Cell Res  2013;247:694
  90. A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.
    Authors: Lazzeroni Et al.
    Exp Neurol  2013;18:984
  91. Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury.
    Authors: Hannan Et al.
    Am J Physiol Lung Cell Mol Physiol  2013;189:1155
  92. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
    Authors: Calvo Et al.
    Nat Cell Biol  2013;15:637
  93. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
    Authors: Crompton Et al.
    Nat Cell Biol  2013;11:1206
  94. Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues.
    Authors: Smith Et al.
    Mol Cancer Res  2013;11:1159
  95. Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
    Authors: Li Et al.
    Proc Natl Acad Sci U S A  2013;110:E1452
  96. ZFX controls the self-renewal of human embryonic stem cells.
    Authors: Harel Et al.
    PLoS One  2012;7:e42302
  97. Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions.
    Authors: Beers Et al.
    Nat Protoc  2012;7:2029
  98. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
    Authors: Neely Et al.
    Proc Natl Acad Sci U S A  2012;3:482
  99. Soluble epoxide hydrolase: sex differences and role in endothelial cell survival.
    Authors: Gupta Et al.
    Arterioscler Thromb Vasc Biol  2012;32:1936
  100. Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG.
    Authors: Walker Et al.
    J Cell Sci  2012;32:14442
  101. Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery.
    Authors: Goulopoulou Et al.
    Am J Physiol Heart Circ Physiol  2012;302:H2477
  102. Neuritogenesis: the prion protein controls β1 integrin signaling activity.
    Authors: Loubet Et al.
    FASEB J  2012;26:678
  103. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.
    Authors: Paige Et al.
    Cell  2012;151:221
  104. Slug and Sox9 cooperatively determine the mammary stem cell state.
    Authors: Guo Et al.
    J Cell Sci  2012;148:1015
  105. Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma.
    Authors: Roller Et al.
    Mol Cancer Ther  2012;11:2505
  106. Measurement and analysis of traction force dynamics in response to vasoactive agonists.
    Authors: Yang Et al.
    Integr Biol (Camb)  2011;3:663
  107. RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.
    Authors: Kaur Et al.
    Arterioscler Thromb Vasc Biol  2011;31:657
  108. Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling.
    Authors: Abreu-Blanco Et al.
    J Cell Biol  2011;193:455
  109. The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder.
    Authors: Lee Et al.
    Dev Biol  2011;15:143
  110. Wnt signaling specifies and patterns intestinal endoderm.
    Authors: Sherwood Et al.
    Mech Dev  2011;128:387
  111. An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
    Authors: Vallenius Et al.
    Integr Biol (Camb)  2011;124:384
  112. Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures.
    Authors: Stiegler Et al.
    Toxicol Sci  2011;121:73
  113. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    Authors: Díez Et al.
    PLoS One  2010;5:e14145
  114. Endogenous patterns of mechanical stress are required for branching morphogenesis.
    Authors: Gjorevski and Nelson
    Stroke  2010;2:424
  115. Cortical actin dynamics facilitate early-stage centrosome separation.
    Authors: Cao Et al.
    J Pharmacol Exp Ther  2010;20:770
  116. Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation.
    Authors: Simões Et al.
    Dev Cell  2010;19:377
  117. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction.
    Authors: Gomez Et al.
    ACS Chem Neurosci  2010;110:44
  118. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts.
    Authors: Kim Et al.
    FEBS Lett  2010;107:17206
  119. The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.
    Authors: Silva-Santos Et al.
    J Biol Chem  2009;37:1716
  120. Cell polarity triggered by cell-cell adhesion via E-cadherin.
    Authors: Desai Et al.
    Br J Pharmacol  2009;122:905
  121. Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility.
    Authors: Giampieri Et al.
    Nat Commun  2009;11:1287
  122. Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.
    Authors: Rodríguez-Vita Et al.
    PLoS One  2008;3:e3959
  123. Emergence of patterned stem cell differentiation within multicellular structures.
    Authors: Ruiz and Chen
    J Cell Sci  2008;26:2921
  124. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
    Authors: Inan and Büyükafşar
    Am J Pathol  2008;155:44
  125. Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy.
    Authors: Bhadriraju Et al.
    J Biol Chem  2007;8:43
  126. Insulin induces airway smooth muscle contraction.
    Authors: Schaafsma Et al.
    Cell Rep  2007;150:136
  127. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin.
    Authors: Muñoz-García Et al.
    Proc Natl Acad Sci U S A  2006;37:2044
  128. Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
    Authors: Guillemot and Citi
    Mol Biol Cell  2006;17:3569
  129. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.
    Authors: Wyckoff Et al.
    Curr Biol  2006;16:1515
  130. Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field.
    Authors: Rajnicek Et al.
    J Cell Sci  2006;119:1723
  131. Endothelin-1, via ETA receptor and independently of transforming growth factor-β, increases the connective tissue growth factor in vascular smooth muscle cells.
    Authors: Rodríguez-Vita Et al.
    Am J Physiol Cell Physiol  2005;97:125
  132. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.
    Authors: Hartmann Et al.
    Oncogene  2005;24:4462
  133. Signal transduction underlying carbachol-induced contraction of human urinary bladder.
    Authors: Schneider Et al.
    J Biol Chem  2004;309:1148
  134. Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases.
    Authors: Fleichman Et al.
    J Pharmacol Exp Ther  2004;308:54
  135. Regulation of MDCK cell-substratum adhesion by RhoA and myosin light chain kinase after ATP depletion.
    Authors: Prahalad Et al.
    Am J Physiol Cell Physiol  2004;286:C693
  136. The activity of the plexin-A1 receptor is regulated by Rac.
    Authors: Turner Et al.
    J Biol Chem  2004;279:33199
  137. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.
    Authors: Surks Et al.
    J Biol Chem  2003;278:51484
  138. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases.
    Authors: Roovers and Assoian
    Mol Cell Biol  2003;23:4283
  139. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.
    Authors: Wibberley Et al.
    Br J Pharmacol  2003;138:757
  140. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine.
    Authors: Altmann Et al.
    Br J Pharmacol  2003;138:261
  141. Rho protein inactivation induced apoptosis of cultured human endothelial cells.
    Authors: Hippenstiel Et al.
    BMC Cell Biol  2002;283:L830
  142. Stiffness changes in cultured airway smooth muscle cells.
    Authors: An Et al.
    Gastroenterology  2002;283:C792
  143. Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway.
    Authors: Jung Et al.
    Br J Pharmacol  2002;277:48931
  144. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.
    Authors: Huang Et al.
    Crit Care Med  2002;277:27265
  145. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition.
    Authors: Vinson Et al.
    J Urol  2001;276:20280
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  Excellent
  Other Anonymous 03/26/2018
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  Human Anonymous 02/01/2018
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Other Experimental Details Keep the stock frozen at -20°C. I use it freshly added to the medium when splitting the cells.
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  Human Hudson DE OLIVEIRA BEZERRA 01/05/2018
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Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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