PJ 34 hydrochloride

Key Product Details

Product Description

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC₅₀ = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC₅₀ values are 3.7 and 16 μM respectively).

Product Specifications for PJ 34 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PJ 34 hydrochloride

The following data is based on the product molecular weight 331.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Antolin Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem.Biol. 2012 PMID: 23025350
• Gambi Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 2008 PMID: 18468580
• Kim Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity. Kidney Int. 2012 PMID: 22437413
• Abdelkarim Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 2001 PMID: 11179503

Product Documents for PJ 34 hydrochloride