PJ 34 hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:3255
Chemical Name:N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively).
Technical Data
  • M.Wt:
    331.8
  • Formula:
    C17H17N3O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    344458-15-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PJ 34 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.
    Authors: Kirby Et al.
    Acta Crystallogr Sect F Struct Biol Cryst Commun  2012;68:115

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