PJ 34 hydrochloride
Chemical Name: N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
Biological ActivityPotent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology.
Antolin et al.
ACS Chem.Biol., 2012;7:1962
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
Abdelkarim et al.
Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines.
Gambi et al.
Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity.
Kim et al.
Kidney Int., 2012;82:193
Citation for PJ 34 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PJ 34 hydrochloride include:
1 Citation: Showing 1 - 1
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.
Authors: Kirby Et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2012;68:115
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