PNU 282987

Key Product Details

Product Description

PNU 282987 is a highly selective α7 nAChR agonist (K_i = 26 nM) displaying negligible blockade of α₁β₁γδ and α₃β₄ nAChRs (IC₅₀ ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT₃ receptors (K_i = 930 nM).

Product Specifications for PNU 282987

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PNU 282987

The following data is based on the product molecular weight 264.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.78 mL	18.89 mL	37.77 mL
5 mM	0.76 mL	3.78 mL	7.55 mL
10 mM	0.38 mL	1.89 mL	3.78 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 68 publications citing the usage of this product.

• Hajós The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe J.Pharmacol.Exp.Ther. 2005 PMID: 15523001
• Bodnar Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J.Med.Chem. 2005 PMID: 15715459

Product Documents for PNU 282987