PNU 282987

  ( 3 citations )    
Product Datasheet
Catalog Number:2303
Chemical Name:N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
Product Details
Citations (3)
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Reviews
Biological Activity
Highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).
Technical Data
  • M.Wt:
    264.75
  • Formula:
    C14H17ClN2O
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    123464-89-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PNU 282987 include:

3 Citations: Showing 1 - 3
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  1. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
    Authors: Zhong Et al.
    Elife  2013;8:e82719
  2. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
    Authors: Pandya and Yakel
    Neuropharmacology  2013;70:35
  3. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
    Authors: Wang Et al.
    J Neurosci  2012;32:9773

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