Highly selective α
7 nAChR agonist (Ki
= 26 nM) displaying negligible blockade of α1β1γδ
≥ 60 μ
M). Found to be inactive against a panel of 32 receptors at 1 μ
M, except 5-HT3
= 930 nM).
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All Tocris products are intended for laboratory research use only.
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors.
Bodnar et al.
The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe
Haj?s et al.
The citations listed below are publications that use Tocris products. Selected citations for PNU 282987 include:
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