Catalog Number: 2303
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
Biological Activity
Highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors.
    Bodnar et al.
    J.Med.Chem., 2005;48:905
  2. The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe
    Haj?s et al.
    J.Pharmacol.Exp.Ther., 2005;312:1213

The citations listed below are publications that use Tocris products. Selected citations for PNU 282987 include:

Showing Results 1 - 2 of 2

  1. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
    Authors: Zhong Et al.
  2. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
    Authors: Wang Et al.
    J Neurosci
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