Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50
~ 150 μ
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All Tocris products are intended for laboratory research use only.
Clinical pharmacokinetics of probenecid.
Cunningham et al.
Glutathione export during apoptosis requires functional multidrug resistance-associated proteins.
Hammond et al.
Probenecid, a gout remedy, inhibits pannexin 1 channels.
Silverman et al.
Am.J.Physiol.Cell Physiol., 2008;295:C761
Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.
Ishikawa et al.
The citations listed below are publications that use Tocris products. Selected citations for Probenecid include:
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