Probenecid

Catalog # Availability Size / Price Qty
4107/50
Multidrug Transporter Inhibitors Small Molecule
1 Image
Description: MRP inhibitor

Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).

Technical Data

M.Wt:
285.36
Formula:
C13H19NO4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
57-66-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Glutathione export during apoptosis requires functional multidrug resistance-associated proteins.
    Hammond et al.
    J.Biol.Chem., 2007;282:14337
  2. Probenecid, a gout remedy, inhibits pannexin 1 channels.
    Silverman et al.
    Am.J.Physiol.Cell Physiol., 2008;295:C761
  3. Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.
    Ishikawa et al.
    Biol.Pharm.Bull., 2010;33:504
  4. Clinical pharmacokinetics of probe.
    Cunningham et al.
    Clin.Pharmacokinet., 1981;6:135

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Probenecid

The citations listed below are publications that use Tocris products. Selected citations for Probenecid include:

2 Citations: Showing 1 - 2

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for Probenecid

There are currently no reviews for this product. Be the first to review Probenecid and earn rewards!

Have you used Probenecid?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.