Catalog Number: 4107
Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Biological Activity
Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Clinical pharmacokinetics of probenecid.
    Cunningham et al.
    Clin.Pharmacokinet., 1981;6:135
  2. Glutathione export during apoptosis requires functional multidrug resistance-associated proteins.
    Hammond et al.
    J.Biol.Chem., 2007;282:14337
  3. Probenecid, a gout remedy, inhibits pannexin 1 channels.
    Silverman et al.
    Am.J.Physiol.Cell Physiol., 2008;295:C761
  4. Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.
    Ishikawa et al.
    Biol.Pharm.Bull., 2010;33:504

The citations listed below are publications that use Tocris products. Selected citations for Probenecid include:

2 Citations: Showing 1 - 2
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  1. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
    Authors: Ostrovskaya Et al.
    J Biomed Sci 2014;21:74
  2. C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.
    Authors: Asgari Et al.
    J Biol Chem 2013;122:3473

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