Catalog # Availability Size / Price Qty
Probenecid | CAS No. 57-66-9 | Multidrug Transporter Inhibitors
1 Image
Description: MRP and OAT3 inhibitor

Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products

Biological Activity

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC50 = 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Glutathione export during apoptosis requires functional multidrug resistance-associated proteins.
    Hammond et al.
    J.Biol.Chem., 2007;282:14337
  2. Probenecid, a gout remedy, inhibits pannexin 1 channels.
    Silverman et al.
    Am.J.Physiol.Cell Physiol., 2008;295:C761
  3. Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.
    Ishikawa et al.
    Biol.Pharm.Bull., 2010;33:504
  4. Clinical pharmacokinetics of probe.
    Cunningham et al.
    Clin.Pharmacokinet., 1981;6:135
  5. Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy.
    Perwitasai et al.
    Antimicrob.Agents Chemother., 2013;57:475

Product Datasheets

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Citations for Probenecid

The citations listed below are publications that use Tocris products. Selected citations for Probenecid include:

2 Citations: Showing 1 - 2


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