Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Biological ActivityInhibitor of multidrug resistance-associated proteins (MRP). Also inhibits OAT3 and inhibits organic acid transport in the kidney and other organs. Exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). Inhibits influenza A virus replication in vitro and in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Glutathione export during apoptosis requires functional multidrug resistance-associated proteins.
Hammond et al.
Probenecid, a gout remedy, inhibits pannexin 1 channels.
Silverman et al.
Am.J.Physiol.Cell Physiol., 2008;295:C761
Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.
Ishikawa et al.
Clinical pharmacokinetics of probe.
Cunningham et al.
Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy.
Perwitasai et al.
Antimicrob.Agents Chemother., 2013;57:475
Citations for Probenecid
The citations listed below are publications that use Tocris products. Selected citations for Probenecid include:
2 Citations: Showing 1 - 2
Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
Authors: Ostrovskaya Et al.
J Biomed Sci 2014;21:74
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.
Authors: Asgari Et al.
J Biol Chem 2013;122:3473
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