Proprotein Convertase 1/PCSK1 Antibody

Novus Biologicals | Catalog # NB120-3532

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Cited:

Mouse, Rat

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Proprotein Convertase 1/PCSK1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1.

Reactivity Notes

Expected cross-reactivity with Bovine base on sequence identity.

Specificity

Prohormone Convertase 1

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Proprotein Convertase 1/PCSK1 Antibody

Western Blot: Proprotein Convertase 1/PCSK1 Antibody [NB120-3532]

Western Blot: Proprotein Convertase 1/PCSK1 Antibody [NB120-3532]

Western Blot: PC1/3 Antibody [NB120-3532] - Analysis of mouse pituitary extract.

Applications for Proprotein Convertase 1/PCSK1 Antibody

Application
Recommended Usage

Western Blot

0.4 ug/ml
Application Notes
WB: Detects an approx. 80 kDa protein representing PC1 from mouse pituitary extract.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Proprotein Convertase 1/PCSK1

The subtilisin-like Prohormone Convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Alternate Names

NEC1, PCSK1

Gene Symbol

PCSK1

Additional Proprotein Convertase 1/PCSK1 Products

Product Documents for Proprotein Convertase 1/PCSK1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Proprotein Convertase 1/PCSK1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Proprotein Convertase 1/PCSK1 Antibody

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