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Proteome Profiler Human XL Cytokine Array Kit

Catalog #: ARY022B
160 Citations 19 Reviews Datasheet / COA / SDS
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
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ARY022B
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The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates.
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Citations (160)
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Proteome Profiler Human XL Cytokine Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of selected human cytokines and chemokines. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma, human milk and saliva.

Key Benefits

  • Detects 105 human cytokines simultaneously
  • Requires no specialized equipment
  • Compatible with LI-COR* and chemiluminescence detection
*If using a LI-COR, additional reagents and protocol modifications are required.  Refer to protocol.
 

Principle of the Array

The Proteome Profiler Human XL Cytokine Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of analyte bound.

Why Use an Antibody Array to Detect Multiple Cytokines?

Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample.

 

Kit Contents
  • Rectangular 4-Well Multi-dish
  • 4 Human XL Cytokine Array nitrocellulose membranes spotted with 105 different antibodies to human cytokines
  • Array Buffer 4
  • Array Buffer 6
  • Chemi Reagent 1
  • Chemi Reagent 2
  • Detection Antibody Cocktail, Human XL Cytokine Array
  • Streptavidin-HRP
  • Transparency Overlay Template
  • Wash Buffer Concentrate (25X)

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 

Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample.
Adiponectin/Acrp30 IFN-gamma CCL2/MCP-1
Angiogenin IGFBP-2 CCL7/MCP-3
Angiopoietin-1 IGFBP-3 M-CSF
Angiopoietin-2 IL-1 alpha/IL-1F1 MIF
Apolipoprotein A1 IL-1 beta/IL-1F2 CXCL9/MIG
BAFF/BLyS/TNFSF13B IL-1ra/IL-1F3 CCL3/CCL4 MIP-1 alpha/beta
BDNF IL-2 CCL20/MIP-3 alpha
CD14 IL-3 CCL19/MIP-3 beta
CD30 IL-4 MMP-9
CD31/PECAM-1 IL-5 Myeloperoxidase
CD40 Ligand/TNFSF5 IL-6 Osteopontin (OPN)
Chitinase 3-like IL-8 PDGF-AA
Complement Component C5/C5a IL-10 PDGF-AB/BB
Complement Factor D IL-11 Pentraxin 3/TSF-14
C-Reactive Protein/CRP IL-12 p70 CXCL4/PF4
Cripto-1 IL-13 RAGE
Cystatin C IL-15 CCL5/RANTES
Dkk-1 IL-16 RBP4
DPPIV/CD26 IL-17A Relaxin-2
EGF IL-18 BPa Resistin
CXCL5/ENA-78 IL-19 CXCL12/SDF-1 alpha
Endoglin/CD105 IL-22 Serpin E1/PAI-1
EMMPRIN IL-23 SHBG
Fas Ligand IL-24 ST2/IL1 R4
FGF basic IL-27 CCL17/TARC
KGF/FGF-7 IL-31 TFF3
FGF-19 IL-32 alpha/beta/gamma TfR
Flt-3 Ligand IL-33 TGF-alpha
G-CSF IL-34 Thrombospondin-1
GDF-15 CXCL10/IP-10 TIM-1
GM-CSF CXCL11/I-TAC TNF-alpha
CXCL1/GRO alpha Kallikrein 3/PSA uPAR
Growth Hormone (GH) Leptin VCAM-1
HGF LIF VEGF
ICAM-1/CD54 Lipocalin-2/NGAL Vitamin D BP

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

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Scientific Data

N/A The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. View Larger

The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. HUVEC human umbilical vein endothelial cells were untreated or treated with 100 µg/mL recombinant human TNF-alpha (Catalog #210-TA) for 24 hours. 500 µL of cell culture supernate was run on each array. Data shown are from a 10 minute exposure to X-ray film. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software.

N/A The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. View Larger

The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. SW480 human colorectal adenocarcinoma cells were untreated or treated with 100 ng/mL of LPS for 24 hours. 500 µL of cell culture supernate was run on each array. Data shown are from a 10 minute exposure to X-ray film. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software.

N/A The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. View Larger

The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. THP-1 human acute monocytic leukemia cells untreated or treated with 1 µg/mL of recombinant human IFN-gamma (Catalog #285-IF) for 16 hours and 1 µ/mL of LPS for 8 hours. 500 µL of cell culture supernate was run on each array. Data shown are from a 10 minute exposure to X-ray film. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software.

Citations for Proteome Profiler Human XL Cytokine Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

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  1. Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis
    Authors: Koroknai, V;Sz�sz, I;Bal�zs, M;
    International journal of molecular sciences  2023-05-17
  2. TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases
    Authors: Kim, J;Lim, J;Yoo, ID;Park, S;Moon, JS;
    Redox biology  2023-05-06
  3. Self-assembled peptide-substance P hydrogels alleviate inflammation and ameliorate the cartilage regeneration in knee osteoarthritis
    Authors: Kim, SJ;Kim, JE;Choe, G;Song, DH;Kim, SJ;Kim, TH;Yoo, J;Kim, SH;Jung, Y;
    Biomaterials research  2023-05-04
  4. Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells
    Authors: AL Pourzia, ML Olson, SR Bailey, AC Boroughs, A Aryal, J Ryan, MV Maus, A Letai
    Cell Death & Disease, 2023-04-13;14(4):267.  2023-04-13
  5. miRNome and Proteome Profiling of Human Keratinocytes and Adipose Derived Stem Cells Proposed miRNA-Mediated Regulations of Epidermal Growth Factor and Interleukin 1-Alpha
    Authors: H Shahin, S Abdallah, J Das, W He, I El-Serafi, I Steinvall, F Sjöberg, M Elmasry, AT El-Serafi
    International Journal of Molecular Sciences, 2023-03-04;24(5):.  2023-03-04
  6. Extracellular Vesicles Derived from Three-Dimensional-Cultured Human Umbilical Cord Blood Mesenchymal Stem Cells Prevent Inflammation and Dedifferentiation in Pancreatic Islets
    Authors: E Lee, S Ha, G Kim, JH Kim, SM Jin
    Stem Cells International, 2023-02-20;2023(0):5475212.  2023-02-20
  7. gp120 Envelope Glycoproteins of HIV-1 Group M Subtype A and Subtype B Differentially Affect Gene Expression in Human Vascular Endothelial Cells
    Authors: AJ Suh, DI Suzuki, SG Gychka, TI Brelidze, YJ Suzuki
    International Journal of Molecular Sciences, 2023-02-10;24(4):.  2023-02-10
  8. Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury
    Authors: ME Mohr, S Li, AM Trouten, RA Stairley, PL Roddy, C Liu, M Zhang, HM Sucov, G Tao
    bioRxiv : the preprint server for biology, 2023-02-08;0(0):.  2023-02-08
  9. Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
    Authors: Y Mo, LL Leung, CSL Mak, X Wang, WS Chan, LMN Hui, HWM Tang, MKY Siu, R Sharma, D Xu, SKW Tsui, HYS Ngan, MMH Yung, KKL Chan, DW Chan
    Molecular Cancer, 2023-01-09;22(1):4.  2023-01-09
  10. gp120 envelope glycoproteins of HIV-1 Group M Subtype A and Subtype B differentially affect gene expression in human vascular endothelial cells
    Authors: AJ Suh, DI Suzuki, SG Gychka, TI Brelidze, YJ Suzuki
    bioRxiv : the preprint server for biology, 2023-01-03;0(0):.  2023-01-03
  11. Pericytes take up and degrade alpha-synuclein but succumb to apoptosis under cellular stress
    Authors: TJ Stevenson, RH Johnson, J Savistchen, J Rustenhove, Z Woolf, LCD Smyth, HC Murray, RLM Faull, J Correia, P Schweder, P Heppner, C Turner, R Melki, BV Dieriks, MA Curtis, M Dragunow
    Scientific Reports, 2022-10-15;12(1):17314.  2022-10-15
  12. Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system
    Authors: A Weigert, X Zheng, A Nenzel, K Turkowski, S Günther, E Strack, E Sirait-Fis, E Elwakeel, IM Kur, VS Nikam, C Valasaraja, H Winter, A Wissgott, R Voswinkel, F Grimminger, B Brüne, W Seeger, SS Pullamsett, R Savai
    Nature Communications, 2022-10-14;13(1):6078.  2022-10-14
  13. The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells
    Authors: V Torres-Est, M Mastri, S Rosario, P Fuenzalida, CE Echeverría, E Flores, A Watts, J Cerda-Infa, VP Montecinos, PC Sotomayor, J Amigo, C Escudero, F Nualart, JML Ebos, DJ Smiraglia, AS Godoy
    Cancers, 2022-09-29;14(19):.  2022-09-29
  14. The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients
    Authors: L Saber Cher, Z Diabasana, JM Perotin, J Ancel, LMG Petit, MA Devilliers, A Bonnomet, N Lalun, G Delepine, U Maskos, P Gosset, M Polette, A Muggeo, T Guillard, G Deslée, V Dormoy
    Cells, 2022-09-20;11(19):.  2022-09-20
  15. ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model
    Authors: YY Wang, AC Hung, YC Wu, S Lo, HD Chen, YK Chen, YC Hsieh, SC Hu, MF Hou, SF Yuan
    Scientific Reports, 2022-09-14;12(1):15437.  2022-09-14
  16. Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases
    Authors: A Anchan, G Finlay, CE Angel, JJW Hucklesby, SE Graham
    Biosensors, 2022-08-19;12(8):.  2022-08-19
  17. During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes
    Authors: E Pylaeva, G Korschunow, I Spyra, S Bordbari, E Siakaeva, I Ozel, M Domnich, A Squire, A Hasenberg, K Thangavelu, T Hussain, M Goetz, KS Lang, M Gunzer, W Hansen, J Buer, A Bankfalvi, S Lang, J Jablonska
    Cell Reports, 2022-08-16;40(7):111171.  2022-08-16
  18. Cell-Type Dependent Regulation of the Electrogenic Na+/HCO3- Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma
    Authors: M Giannaki, DE Ruf, E Pfeifer, K Everaerts, DH Heiland, O Schnell, CR Rose, E Roussa
    International Journal of Molecular Sciences, 2022-08-11;23(16):.  2022-08-11
  19. Plasmid-mediated gene transfer of Cas9 induces vector-related but not SpCas9-related immune responses in human retinal pigment epithelial cells
    Authors: JK Pfromm, M Bonillo, D Dauletbeko, K Bucher, MD Fischer
    Scientific Reports, 2022-08-01;12(1):13202.  2022-08-01
  20. Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
    Authors: BF Vahsen, E Gray, A Candalija, KML Cramb, J Scaber, R Dafinca, A Katsikoudi, Y Xu, L Farrimond, R Wade-Marti, WS James, MR Turner, SA Cowley, K Talbot
    Scientific Reports, 2022-07-23;12(1):12606.  2022-07-23
  21. Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance
    Authors: R Islam, J Mishra, NS Polavaram, S Bhattachar, Z Hong, S Bodas, S Sharma, A Bouska, T Gilbreath, AM Said, LM Smith, BA Teply, MH Muders, SK Batra, K Datta, S Dutta
    Oncogene, 2022-07-19;40(3):111097.  2022-07-19
  22. Targeting HIC1/TGF-beta axis-shaped prostate cancer microenvironment restrains its progression
    Authors: T Wu, W Wang, G Shi, M Hao, Y Wang, M Yao, Y Huang, L Du, X Zhang, D Ye, X Bian, J Wang
    Cell Death & Disease, 2022-07-19;13(7):624.  2022-07-19
  23. Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells
    Authors: N Igarashi, K Miyata, TM Loo, M Chiba, A Hanyu, M Nishio, H Kawasaki, H Zheng, S Toyokuni, S Kon, K Moriyama, Y Fujita, A Takahashi
    Oncogene, 2022-07-18;13(1):4157.  2022-07-18
  24. Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1
    Authors: H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt, PL Molyneaux, ML Gore, Breathing, WS Barclay, S Saglani, CM Lloyd
    Mucosal Immunology, 2022-07-15;0(0):.  2022-07-15
  25. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
    Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
    Elife, 2022-07-11;11(0):.  2022-07-11
  26. Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line
    Authors: R Tanaka, K Kimura, S Eguchi, G Ohira, S Tanaka, R Amano, H Tanaka, M Yashiro, M Ohira, S Kubo
    BMC Cancer, 2022-07-08;22(1):748.  2022-07-08
  27. The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
    Authors: C Ji, M Zhang, J Hu, C Cao, Q Gu, Y Liu, X Li, D Xu, L Ying, Y Yang, H Gao, J Li, L Yu
    Cell Death & Disease, 2022-07-01;13(7):577.  2022-07-01
  28. Two New Potential Therapeutic Approaches in Radiation Cystitis Derived from Mesenchymal Stem Cells: Extracellular Vesicles and Conditioned Medium
    Authors: C Helissey, N Guitard, H Théry, S Goulinet, P Mauduit, M Girleanu, AL Favier, M Drouet, C Parnot, C Chargari, S Cavallero, S François
    Biology, 2022-06-28;11(7):.  2022-06-28
  29. Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis
    Authors: MC Cao, EE Cawston, G Chen, C Brooks, J Douwes, D McLean, ES Graham, M Dragunow, EL Scotter
    BMC neurology, 2022-06-11;22(1):216.  2022-06-11
  30. Human Osteochondral Explants as an Ex Vivo Model of Osteoarthritis for the Assessment of a Novel Class of Orthobiologics
    Authors: C Giannasi, L Mangiavini, S Niada, A Colombo, E Della Mort, V Vismara, A Ambrosanio, P Savadori, S Casati, GM Peretti, AT Brini
    Pharmaceutics, 2022-06-10;14(6):.  2022-06-10
  31. Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions
    Authors: L Brandolini, M d'Angelo, R Novelli, V Castelli, C Giorgio, A Sirico, P Cocchiaro, F D'Egidio, E Benedetti, C Cristiano, A Bugatti, A Ruocco, PG Amendola, C Talarico, C Manelfi, D Iaconis, A Beccari, AU Quadros, TM Cunha, A Caruso, R Russo, A Cimini, A Aramini, M Allegretti
    Cell Death & Disease, 2022-05-25;13(5):500.  2022-05-25
  32. LCN2 is a new diagnostic biomarker and potential therapeutic target in idiopathic short stature
    Authors: X Liu, J Zhang, J Yuan, R Ding, T Liu, J Jia
    Journal of Cellular and Molecular Medicine, 2022-05-24;0(0):.  2022-05-24
  33. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
    Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
    Cancers, 2022-05-09;14(9):.  2022-05-09
  34. IFN-gamma and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
    Authors: L Homann, M Rentschler, E Brenner, K Böhm, M Röcken, T Wieder
    Cells, 2022-04-30;11(9):.  2022-04-30
  35. Preferential stimulation of melanocytes by M2 macrophages to produce melanin through vascular endothelial growth factor
    Authors: H Han, Y Kim, H Mo, SH Choi, K Lee, YA Rim, JH Ju
    Scientific Reports, 2022-04-19;12(1):6416.  2022-04-19
  36. ERalpha36-High Cancer-Associated Fibroblasts as an Unfavorable Factor in Triple-Negative Breast Cancer
    Authors: A Nagel, M Popeda, A Muchlinska, R Sadej, J Szade, J Zielinski, J Skokowski, M Niemira, A Kretowski, A Markiewicz, AJ Zaczek
    Cancers, 2022-04-15;14(8):.  2022-04-15
  37. Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair
    Authors: X Zhang, S Zheng, C Hu, G Li, H Lin, R Xia, Y Ye, R He, Z Li, Q Lin, R Chen, Q Zhou
    Oncogene, 2022-03-09;0(0):.  2022-03-09
  38. Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization
    Authors: M Saumell-Es, D Delgado, G García Del, M Beitia, J Sallés, I González-B, P Sánchez, M López de J, S Barrondo, M Sánchez
    International Journal of Molecular Sciences, 2022-03-05;23(5):.  2022-03-05
  39. Na�ve Human Macrophages Are Refractory to SARS-CoV-2 Infection and Exhibit a Modest Inflammatory Response Early in Infection
    Authors: Z Zhang, R Penn, WS Barclay, ES Giotis
    Viruses, 2022-02-21;14(2):.  2022-02-21
  40. Ibuprofen in Therapeutic Concentrations Affects the Secretion of Human Bone Marrow Mesenchymal Stromal Cells, but Not Their Proliferative and Migratory Capacity
    Authors: A Kulesza, K Zielniok, J Hawryluk, L Paczek, A Burdzinska
    Biomolecules, 2022-02-10;12(2):.  2022-02-10
  41. Analysis of gingival crevicular fluid biomarkers in patients with metabolic syndrome
    Authors: L Nibali, A Stephen, E Hagi-Pavli, R Allaker, AD Pino, V Terranova, M Pisano, SD Marca, V Ferrara, R Scicali, M Giordano, F Purrello, N Donos, L Malatino
    Journal of dentistry, 2022-02-06;118(0):104065.  2022-02-06
  42. Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis
    Authors: R Pohl, S Feder, EM Haberl, L Rein-Fisch, TS Weiss, M Spirk, A Bruckmann, N McMullen, CJ Sinal, C Buechler
    Biomedicines, 2022-01-07;10(1):.  2022-01-07
  43. Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines
    Authors: INF Gomes, RJ da Silva-O, LS da Silva, O Martinho, AF Evangelist, A van Helvoo, LF Leal, VAO Silva, SP Dos Santos, FC Nascimento, A Lopes Carv, RM Reis
    Cells, 2022-01-04;11(1):.  2022-01-04
  44. Diphenylarsinic acid induced activation of MAP kinases, transcription factors, and oxidative stress-responsive factors and hypersecretion of cytokines in cultured normal human cerebellar astrocytes
    Authors: S Sasaki, T Negishi, T Tsuzuki, K Yukawa
    Neurotoxicology, 2021-12-06;88(0):196-207.  2021-12-06
  45. Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
    Authors: M Bolis, D Bossi, A Vallerga, V Ceserani, M Cavalli, D Impellizzi, L Di Rito, E Zoni, S Mosole, AR Elia, A Rinaldi, R Pereira Me, E D'Antonio, M Ferrari, F Stoffel, F Jermini, S Gillessen, L Bubendorf, P Schraml, A Calcinotto, E Corey, H Moch, M Spahn, G Thalmann, M Kruithof-d, MA Rubin, JP Theurillat
    Nature Communications, 2021-12-02;12(1):7033.  2021-12-02
  46. C-C Motif Chemokine Ligand-17 as a Novel Biomarker and Regulator of Epithelial Mesenchymal Transition in Renal Fibrogenesis
    Authors: YH Hsieh, WC Wang, TW Hung, CC Lee, JP Tsai
    Cells, 2021-11-29;10(12):.  2021-11-29
  47. Reduction of Oxidative Stress in Peripheral Blood Mononuclear Cells Attenuates the Inflammatory Response of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
    Authors: HR Lee, SJ Yoo, J Kim, CK Park, SW Kang
    International Journal of Molecular Sciences, 2021-11-17;22(22):.  2021-11-17
  48. Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer
    Authors: WX Peng, P Koirala, H Zhou, J Jiang, Z Zhang, L Yang, YY Mo
    Cell Death & Disease, 2021-10-25;12(11):1000.  2021-10-25
  49. Cancer testis antigen PRAME: An anti-cancer target with immunomodulatory potential
    Authors: A Naik, R Thomas, G Al-Khadair, R Bacha, W Hendrickx, J Decock
    Journal of Cellular and Molecular Medicine, 2021-10-06;0(0):.  2021-10-06
  50. Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment
    Authors: S Hong, JY You, K Paek, J Park, SJ Kang, EH Han, N Choi, S Chung, WJ Rhee, JA Kim
    Theranostics, 2021-09-27;11(19):9687-9704.  2021-09-27
  51. Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells
    Authors: L Kobari, M Auclair, O Piau, N Ferrand, M Zaoui, F Delhommeau, B Fève, M Sabbah, L Garderet
    Leukemia, 2021-09-23;0(0):.  2021-09-23
  52. Metallothionein 2A Expression in Cancer-Associated Fibroblasts and Cancer Cells Promotes Esophageal Squamous Cell Carcinoma Progression
    Authors: M Shimizu, YI Koma, H Sakamoto, S Tsukamoto, Y Kitamura, S Urakami, K Tanigawa, T Kodama, N Higashino, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki
    Cancers, 2021-09-10;13(18):.  2021-09-10
  53. Gelatin methacrylate hydrogels culture model for glioblastoma cells enriches for mesenchymal-like state and models interactions with immune cells
    Authors: N Shah, PM Hallur, RA Ganesh, P Sonpatki, D Naik, KP Chandracha, RB Puchalski, A Chaubey
    Scientific Reports, 2021-09-06;11(1):17727.  2021-09-06
  54. Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
    Authors: P Vigneault, S Parent, P Kanda, C Michie, DR Davis, S Nattel
    Nature Communications, 2021-08-16;12(1):4963.  2021-08-16
  55. CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
    Authors: S Durlanik, K Fundel-Cle, C Viollet, HJ Huber, M Lenter, K Kitt, S Pflanz
    Scientific Reports, 2021-07-21;11(1):14849.  2021-07-21
  56. Transcryptomic Analysis of Human Brain -Microvascular Endothelial Cell Driven Changes in -Vascular Pericytes
    Authors: L Kurmann, M Okoniewski, RK Dubey
    Cells, 2021-07-14;10(7):.  2021-07-14
  57. Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1alpha
    Authors: J Park, M Lee, M Kim, S Moon, S Kim, S Kim, SH Koh, YM Kim, YK Choi
    Journal of Ginseng Research, 2021-07-12;46(3):408-417.  2021-07-12
  58. Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC
    Authors: RN Hawthorne, A Blazeski, J Lowenthal, S Kannan, R Teuben, D DiSilvestr, J Morrissett, JE Saffitz, KR Boheler, CA James, SP Chelko, G Tomaselli, L Tung
    Journal of Clinical Medicine, 2021-07-10;10(14):.  2021-07-10
  59. Combination of Epithelial Growth Factor Receptor Blockers and CDK4/6 Inhibitor for Nasopharyngeal Carcinoma Treatment
    Authors: HP Li, CY Huang, KW Lui, YK Chao, CN Yeh, LY Lee, Y Huang, TL Lin, YC Kuo, MY Huang, YR Lai, YM Yeh, HC Fan, AC Lin, JC Hsieh, KP Chang, CY Lin, HM Wang, YS Chang, CL Hsu
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  60. Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
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FAQs

  1. Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?

    • The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment. 

  2. Could you tell us whether this MMP-9 antibody can detect TIMP and MMP-9 complex?

    • We haven't performed a large amount of specificity testing per each spot in the arrays because these are qualitative screening tools. However, we would recommend treating the MMP-9 spot as a "Total MMP-9" detecting both free MMP-9 and MMP-9 in complex. If the MMP-9 spot turns out to be of high interest for the customer's study, they will want to examine this target in more detail with quantitative tools such as ELISA or Luminex.

View all Proteome Profiler Antibody Array FAQs

Reviews for Proteome Profiler Human XL Cytokine Array Kit

Average Rating: 4.6 (Based on 19 Reviews)

5 Star
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Proteome Profiler Human XL Cytokine Array Kit
By Dong Hu on 07/11/2022
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 05/13/2022

Product was easy to use and quick. In house analysis software would improve the process. Array has not been tested if the specific antibodies differentiate between precursor and mature proteins or bound vs unbound proteins. Testing this would increase applicability. Image provided is an example of 100 ul of human serum.

Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 12/02/2021
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 10/21/2021
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 09/07/2021
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 04/29/2021

Used 1 ml of pooled basal media from air-liquid interface cultures of primary epithelial cells

Protocol very easy to follow, but data analysis can be tricky. Would benefit massively from coming with its own analysis tool / ImageJ plugin.

Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 10/20/2020
Proteome Profiler Human XL Cytokine Array Kit
By Dhanush Haspula on 05/22/2020

220 uL of rat plasma for overnight incubation with arrays at 4c.

Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Louise Reynolds on 02/18/2020

Human endothelial cells treated +/- FAK kinase inhibitors +/- doxorubicin

Proteome Profiler Human XL Cytokine Array Kit
By Lucia Lisi on 01/14/2020

Chiavari M, Ciotti GMP, Navarra P, Lisi L. Pro-Inflammatory Activation of A New Immortalized Human Microglia Cell Line. Brain Sci. 2019;9(5):111. Published 2019 May 15. doi:10.3390/brainsci9050111

Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Fadi Saadeh on 07/01/2019
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 06/07/2019
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 06/06/2019
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 02/07/2019
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Ivan Luzardo on 01/03/2019
Proteome Profiler Human XL Cytokine Array Kit
By Samantha Scarneo on 12/26/2018
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Scott Scarneo on 12/12/2018

THP-1 Cells stimulated with LPS+IFN gamma for 24 hours.

Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Anonymous on 09/14/2018
Proteome Profiler Human XL Cytokine Array Kit ARY022B
Proteome Profiler Human XL Cytokine Array Kit
By Leslie Priddy on 04/01/2018