Recombinant Human IFN-gamma Protein

(217 citations)
(5 Reviews)
  
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 129. The ED50 for this effect is 0.15-0.75 ng/mL.
    The specific activity of Recombinant Human IFN-gamma is approximately 2 x 104 IU/μg, which is calibrated against human IFN-gamma Standard (NIBSC code: 87/586).
  • Source
    E. coli-derived Gln24-Gln166 with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Met
  • Predicted Molecular Mass
    16.9 kDa
  • SDS-PAGE
    17 kDa, reducing conditions
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
285-IF
 
285-IF/CF
Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80 with BSA as a carrier protein.
Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80.
Reconstitution Reconstitute at 0.2 mg/mL in sterile, deionized water.  
Reconstitution Reconstitute at 0.2 mg/mL in sterile, deionized water. 
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Human IFN-gamma (Catalog # 285‑IF) demonstrates anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. The ED50 for this effect is 0.15‑0.75 ng/mL.
1 μg/lane of Recombinant Human IFN-gamma was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.
Background: IFN-gamma
Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 90% amino acid (aa) sequence identity with rhesus IFN-gamma, 59%‑64% with bovine, canine, equine, feline, and porcine IFN‑ gamma, and 37%‑43% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI ( alpha subunits) which then interact with IFN-gamma RII ( beta  subunits) to form the functional receptor complex of two alpha and two beta  subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).
  • References:
    1. Billiau, A. and P. Matthys (2009) Cytokine Growth Factor Rev. 20:97.
    2. Pestka, S. et al. (2004) Immunol. Rev. 202:8.
    3. Gray, P.W. and D.V. Goeddel (1982) Nature 298:859.
    4. Marsters, S.A. et al. (1995) Proc. Natl. Acad. Sci. 92:5401.
    5. Krause, C.D. et al. (2000) J. Biol. Chem. 275:22995.
    6. Schroder, K. et al. (2004) J. Leukoc. Biol. 75:163.
    7. McLaren, J.E. and D.P. Ramji (2009) Cytokine Growth Factor Rev. 20:125.
    8. Muhl, H. and J. Pfeilschifter (2003) Int. Immunopharmacol. 3:1247.
    9. Kelchtermans, H. et al. (2008) Trends Immunol. 29:479.
  • Long Name:
    Interferon gamma
  • Entrez Gene IDs:
    3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
  • Alternate Names:
    IFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

217 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients
    Authors: N Hakimzadeh, J Elias, GWM Wijntjens, R Theunissen, A van Weert, MW Smulders, N van den Ak, PD Moerland, HJ Verberne, LP Hoebers, JPS Henriques, AM van der La, M Ilhan, M Post, SCAM Bekkers, JJ Piek
    Sci Rep, 2017;7(1):1532.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  2. Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency
    Authors: N Starc, D Ingo, A Conforti, V Rossella, L Tomao, A Pitisci, F De Mattia, I Brigida, M Algeri, M Montanari, G Palumbo, P Merli, P Rossi, A Aiuti, F Locatelli, ME Bernardo
    Sci Rep, 2017;7(1):8153.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  3. A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors
    Authors: A Pavesi, AT Tan, S Koh, A Chia, M Colombo, E Antonecchi, C Miccolis, E Ceccarello, G Adriani, MT Raimondi, RD Kamm, A Bertoletti
    JCI Insight, 2017;2(12):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  4. Rheumatoid arthritis and psoriatic arthritis synovial fluid stimulates prolactin production by macrophages
    Authors: MW Tang, S Garcia, B Malvar Fer, DM Gerlag, PP Tak, KA Reedquist
    J. Leukoc. Biol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  5. Image based Machine Learning for identification of macrophage subsets
    Authors: HM Rostam, PM Reynolds, MR Alexander, N Gadegaard, AM Ghaemmagha
    Sci Rep, 2017;7(1):3521.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. Mycobacterium tuberculosis ESAT6 and CPF10 Induce Adenosine Deaminase 2 mRNA Expression in Monocyte-Derived Macrophages
    Authors: MJ Bae, S Ryu, HJ Kim, SI Cha, CH Kim, J Lee
    Tuberc Respir Dis (Seoul), 2017;80(1):77-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  7. Salt suppresses IFN? inducible chemokines through the IFN?-JAK1-STAT1 signaling pathway in proximal tubular cells
    Authors: Y Arai, D Takahashi, K Asano, M Tanaka, M Oda, SBH Ko, MSH Ko, S Mandai, N Nomura, T Rai, S Uchida, E Sohara
    Sci Rep, 2017;7(0):46580.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage
    Authors: A Raimondo, S Lembo, RD Caprio, G Donnarumma, G Monfrecola, N Balato, F Ayala, A Balato
    Eur. J. Immunol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  9. Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum
    Authors: MA Terkawi, R Takano, A Furukawa, F Murakoshi, K Kato
    Sci Rep, 2017;7(0):41772.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor D-1-methyl-tryptophan
    Authors: X Zhang, Y Yang, L Zhang, Y Lu, Q Zhang, D Fan, Y Zhang, Y Zhang, Z Ye, D Xiong
    J Hematol Oncol, 2017;10(1):56.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  11. Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36?
    Authors: JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(13):E2748-E2757.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC
    Authors: J Huang, F Shen, H Huang, C Ling, G Zhang
    Oncotarget, 2017;8(8):13116-13125.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  13. Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
    Authors: E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux
    Stem Cell Res Ther, 2017;8(1):79.
    Species: Human
    Sample Type: Whole Cells
    Application: c, Bioassay
  14. Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma
    Authors: JY Ao, XD Zhu, ZT Chai, H Cai, YY Zhang, KZ Zhang, LQ Kong, N Zhang, BG Ye, DN Ma, HC Sun
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  15. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
    Authors: L Tian, A Goldstein, H Wang, H Ching Lo, I Sun Kim, T Welte, K Sheng, LE Dobrolecki, X Zhang, N Putluri, TL Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, WK Decker, C Zong, MT Lewis, XH Zhang
    Nature, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  16. IFN type I and II induce BAFF secretion from human decidual stromal cells
    Authors: AC Lundell, I Nordstr”m, K Andersson, C Lundqvist, E Telemo, S Nava, H Kaipe, A Rudin
    Sci Rep, 2017;7(0):39904.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  17. NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy
    Authors: Q Wu, A Allouch, A Paoletti, C Leteur, C Mirjolet, I Martins, L Voisin, F Law, H Dakhli, E Mintet, M Thoreau, Z Muradova, M Gauthier, O Caron, F Milliat, DM Ojcius, F Rosselli, E Solary, N Modjtahedi, E Deutsch, JL Perfettini
    Cell Death Differ., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  18. Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia
    Authors: MH van Atteku, S Terpstra, E Slinger, M von Linder, PD Moerland, A Jongejan, AP Kater, E Eldering
    Oncogene, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  19. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding kinase 1 (TBK1) to Restrain STAT3 Activity
    Authors: HC Hsia, JE Hutti, AS Baldwin
    J. Biol. Chem, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  20. Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii
    Authors: A Qin, DH Lai, Q Liu, W Huang, YP Wu, X Chen, S Yan, H Xia, G Hide, ZR Lun, FJ Ayala, AP Xiang
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  21. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation
    Authors: MA Schumacher, M Hedl, C Abraham, JK Bernard, PR Lozano, JJ Hsieh, D Almohazey, EB Bucar, S Punit, PJ Dempsey, MR Frey
    Cell Death Dis, 2017;8(2):e2622.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  22. Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype
    Sci Rep, 2016;6(0):29712.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  23. Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells
    Int J Mol Sci, 2016;17(11):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA
    Mol Immunol, 2016;77(0):205-212.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  25. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages
    Authors: Takuya Matsumoto
    Arthritis Res Ther, 2016;18(1):133.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients
    BMC Cancer, 2016;16(1):744.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  27. Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes
    Authors: G Karina Chimal-Ram
    J Immunol Res, 2016;2016(0):6031486.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  28. Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis
    Authors: M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu, D Ren, B Yu, L Zheng, X Hu, W Shi, J Xu
    Stem Cell Res Ther, 2016;7(1):63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.
    Authors: Guo Z, Zheng L, Liao X, Geller D
    PLoS ONE, 2016;11(1):e0146640.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  30. PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer.
    Authors: Nagarsheth N, Peng D, Kryczek I, Wu K, Li W, Zhao E, Zhao L, Wei S, Frankel T, Vatan L, Szeliga W, Dou Y, Owens S, Marquez V, Tao K, Huang E, Wang G, Zou W
    Cancer Res, 2016;76(2):275-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  31. PD-1/PD-L1 blockade enhances T cell activity and antitumor efficacy of imatinib in gastrointestinal stromal tumors
    Clin Cancer Res, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  32. Identification of a major epitope by anti-interferon-? autoantibodies in patients with mycobacterial disease
    Nat Med, 2016;0(0):.
    Species: Human
    Sample Type: Plasma
    Application: WB Ctrl
  33. CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
    Authors: Martine Schrøder
    PLoS ONE, 2016;11(6):e0157387.
    Species: Human
    Sample Type: Cell Culture Supernates
    Application: Bioassay
  34. B cell IFN-? receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
    Authors: SW Jackson, HM Jacobs, T Arkatkar, EM Dam, NE Scharping, NS Kolhatkar, B Hou, JH Buckner, DJ Rawlings
    J Exp Med, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  35. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
    Authors: Kellie N Smith
    MBio, 2016;7(3):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  36. Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
    Elife, 2016;5(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  37. TLR3 preconditioning enhances the therapeutic efficacy of umbilical cord mesenchymal stem cells in TNBS-induced colitis via the TLR3-Jagged-1-Notch-1 pathway
    Mucosal Immunol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  38. Interferon-? blocks signalling through PDGFR? in human brain pericytes
    J Neuroinflammation, 2016;13(1):249.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  39. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic
    Proc Natl Acad Sci USA, 2016;113(38):10643-10648.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  40. Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells
    PLoS ONE, 2016;11(12):e0167361.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  41. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015;194(5):2330-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. IFN-gamma from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer.
    Authors: Abiko K, Matsumura N, Hamanishi J, Horikawa N, Murakami R, Yamaguchi K, Yoshioka Y, Baba T, Konishi I, Mandai M
    Br J Cancer, 2015;112(9):1501-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  43. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
    Authors: Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D
    J Invest Dermatol, 2015;135(7):1771-80.
  44. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
    Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
    Respir Res, 2015;16(0):14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  45. Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-gamma-treated macrophages to Pseudomonas aeruginosa infection.
    Authors: Singh S, Barr H, Liu Y, Robins A, Heeb S, Williams P, Fogarty A, Camara M, Martinez-Pomares L
    PLoS ONE, 2015;10(2):e0117447.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  46. Identification of a nuclear export sequence in the MHC CIITA.
    Authors: Chiu E, Gold T, Fettig V, LeVasseur M, Cressman D
    J Immunol, 2015;194(12):6102-11.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  47. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
    Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
    Invest Ophthalmol Vis Sci, 2015;56(2):1051-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  48. Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis.
    Authors: Kenna T, Lau M, Keith P, Ciccia F, Costello M, Bradbury L, Low P, Agrawal N, Triolo G, Alessandro R, Robinson P, Thomas G, Brown M
    Genes Immun, 2015;16(1):35-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  49. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells.
    Authors: Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, Ghigo D, Riganti C
    PLoS ONE, 2015;10(5):e0126159.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  50. TIM-3/Gal-9 interaction induces IFNgamma-dependent IDO1 expression in acute myeloid leukemia blast cells.
    Authors: Folgiero V, Cifaldi L, Li Pira G, Goffredo B, Vinti L, Locatelli F
    J Hematol Oncol, 2015;8(0):36.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  51. Activated Brain Endothelial Cells Cross-Present Malaria Antigen.
    Authors: Howland S, Poh C, Renia L
    PLoS Pathog, 2015;11(6):e1004963.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  52. Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
    Authors: Spampinato S, Obermeier B, Cotleur A, Love A, Takeshita Y, Sano Y, Kanda T, Ransohoff R
    PLoS ONE, 2015;10(7):e0133392.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. Interferon-gamma Inhibits Ebola Virus Infection.
    Authors: Rhein B, Powers L, Rogers K, Anantpadma M, Singh B, Sakurai Y, Bair T, Miller-Hunt C, Sinn P, Davey R, Monick M, Maury W
    PLoS Pathog, 2015;11(11):e1005263.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage.
    Authors: Catanzaro D, Rancan S, Orso G, Dall'Acqua S, Brun P, Giron M, Carrara M, Castagliuolo I, Ragazzi E, Caparrotta L, Montopoli M
    PLoS ONE, 2015;10(5):e0125375.
  55. IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.
    Authors: Maleki Vareki S, Chen D, Di Cresce C, Ferguson P, Figueredo R, Pampillo M, Rytelewski M, Vincent M, Min W, Zheng X, Koropatnick J
    PLoS ONE, 2015;10(11):e0143435.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  56. Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.
    Authors: Zhao Y, Scott N, Quah H, Krishnamurthy B, Bond F, Loudovaris T, Mannering S, Kay T, Thomas H
    Eur J Immunol, 2015;45(9):2494-503.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  57. The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses.
    Authors: Arnold C, Gordon P, Barker R, Wilson H
    Immunobiology, 2015;220(1):10-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  58. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.
    Authors: Reiner A, Heldt S, Presley C, Guley N, Elberger A, Deng Y, D'Surney L, Rogers J, Ferrell J, Bu W, Del Mar N, Honig M, Gurley S, Moore B
    Int J Mol Sci, 2014;16(1):758-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  59. Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2.
    Authors: Engstrom A, Erlandsson A, Delbro D, Wijkander J
    Int J Oncol, 2014;44(2):385-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  60. An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma.
    Authors: Voraphani N, Gladwin M, Contreras A, Kaminski N, Tedrow J, Milosevic J, Bleecker E, Meyers D, Ray A, Ray P, Erzurum S, Busse W, Zhao J, Trudeau J, Wenzel S
    Mucosal Immunol, 2014;7(5):1175-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  61. No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.
    Authors: Culina S, Mauvais F, Hsu H, Burgevin A, Guenette S, Moser A, van Endert P
    PLoS ONE, 2014;9(2):e88365.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  62. cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells.
    Authors: Valle Oseguera, Cendy A, Spencer, Juliet V
    PLoS ONE, 2014;9(2):e88708.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  63. Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication.
    Authors: Berri F, Haffar G, Le V, Sadewasser A, Paki K, Lina B, Wolff T, Riteau B
    J Virol, 2014;88(19):11215-28.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  64. Nitric oxide enhances Th9 cell differentiation and airway inflammation.
    Authors: Niedbala W, Besnard A, Nascimento D, Donate P, Sonego F, Yip E, Guabiraba R, Chang H, Fukada S, Salmond R, Schmitt E, Bopp T, Ryffel B, Liew F
    Nat Commun, 2014;5(0):4575.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  65. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
    Authors: Cichocki F, Schlums H, Li H, Stache V, Holmes T, Lenvik T, Chiang S, Miller J, Meeths M, Anderson S, Bryceson Y
    J Exp Med, 2014;211(6):1079-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  66. G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.
    Authors: Fryer, Ryan M, Ng, Khing Jo, Nodop Mazurek, Suzanne, Patnaude, Lori, Skow, Donna J, Muthukumarana, Akalushi, Gilpin, Kyle E, Dinallo, Roger M, Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christia, Cerny, Matthew, Hickey, Eugene R, Modis, Louise K
    J Pharmacol Exp Ther, 2014;348(3):421-31.
    Species: Human
    Sample Type: Plasma
    Application: Bioassay
  67. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
    Authors: Deng B, Wang C, Arnardottir H, Li Y, Cheng C, Dalli J, Serhan C
    PLoS ONE, 2014;9(7):e102362.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  68. Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul.
    Authors: Jebran A, Schleicher U, Steiner R, Wentker P, Mahfuz F, Stahl H, Amin F, Bogdan C, Stahl K
    PLoS Negl Trop Dis, 2014;8(2):e2694.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.
    Authors: Uhlenbrock F, Hagemann-Jensen M, Kehlet S, Andresen L, Pastorekova S, Skov S
    J Immunol, 2014;193(4):1654-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  70. Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro.
    Authors: Italiani, Paola, Mazza, Emilia M, Lucchesi, Davide, Cifola, Ingrid, Gemelli, Claudia, Grande, Alexis, Battaglia, Cristina, Bicciato, Silvio, Boraschi, Diana
    PLoS ONE, 2014;9(2):e87680.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  71. The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8(+) T cell responses.
    Authors: Melhem N, Smith K, Huang X, Colleton B, Jiang W, Mailliard R, Mullins J, Rinaldo C
    Virology, 2014;450(0):34-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  72. A role for human brain pericytes in neuroinflammation.
    Authors: Jansson D, Rustenhoven J, Feng S, Hurley D, Oldfield R, Bergin P, Mee E, Faull R, Dragunow M
    J Neuroinflammation, 2014;11(0):104.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  73. TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.
    Authors: Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H
    Proc Natl Acad Sci U S A, 2014;111(4):1509-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  74. slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells.
    Authors: Vermi W, Micheletti A, Lonardi S, Costantini C, Calzetti F, Nascimbeni R, Bugatti M, Codazzi M, Pinter P, Schakel K, Tamassia N, Cassatella M
    Nat Commun, 2014;5(0):3029.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  75. Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.
    Authors: Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C, Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y
    PLoS ONE, 2014;9(1):e86426.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  76. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
    Authors: Milwid, Jack M, Elman, Jessica, Li, Matthew, Shen, Keyue, Manrai, Arjun, Gabow, Aaron, Yarmush, Joshua, Jiao, Yunxin, Fletcher, Anne, Lee, Jungwoo, Cima, Michael, Yarmush, Martin L, Parekkadan, Biju
    Mol Ther, 2014;22(5):999-1007.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  77. Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy.
    Authors: Ji, Jianfei, Judkowski, Valeria, Liu, Gentao, Wang, Hongqian, Bunying, Alcinett, Li, Zhenhua, Xu, Minlin, Bender, James, Pinilla, Clemenci, Yu, John S
    Stem Cells Transl Med, 2014;3(3):356-64.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  78. Monitoring the initiation and kinetics of human dendritic cell-induced polarization of autologous naive CD4+ T cells.
    Authors: Oth, Tammy, Schnijderberg, Melanie, Senden-Gijsbers, Birgit L, Germeraad, Wilfred, Bos, Gerard M, Vanderlocht, Joris
    PLoS ONE, 2014;9(8):e103725.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  79. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.
    Authors: MacLeod A, Rudolph R, Corriden R, Ye I, Garijo O, Havran W
    J Immunol, 2014;192(12):5695-702.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  80. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.
    Authors: Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H
    J Immunol, 2014;192(1):59-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  81. MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.
    Authors: Lopez-Ramirez M, Wu D, Pryce G, Simpson J, Reijerkerk A, King-Robson J, Kay O, de Vries H, Hirst M, Sharrack B, Baker D, Male D, Michael G, Romero I
    FASEB J, 2014;28(6):2551-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  82. CD14 mediates Toll-like receptor 4 (TLR4) endocytosis and spleen tyrosine kinase (Syk) and interferon regulatory transcription factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo.
    Authors: Roy S, Karmakar M, Pearlman E
    J Biol Chem, 2014;289(2):1174-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  83. Hemin controls T cell polarization in sickle cell alloimmunization.
    Authors: Zhong H, Bao W, Friedman D, Yazdanbakhsh K
    J Immunol, 2014;193(1):102-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  84. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
    Authors: Suzuki, Hitoshi, Raska, Milan, Yamada, Koshi, Moldoveanu, Zina, Julian, Bruce A, Wyatt, Robert J, Tomino, Yasuhiko, Gharavi, Ali G, Novak, Jan
    J Biol Chem, 2014;289(8):5330-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  85. Eosinophils regulate peripheral B cell numbers in both mice and humans.
    Authors: Wong, Tina W, Doyle, Alfred D, Lee, James J, Jelinek, Diane F
    J Immunol, 2014;192(8):3548-58.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  86. Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.
    Authors: Garcia S, Krausz S, Ambarus C, Fernandez B, Hartkamp L, van Es I, Hamann J, Baeten D, Tak P, Reedquist K
    PLoS ONE, 2014;9(1):e82088.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  87. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kappaB modulation.
    Authors: Ren Z, Kang W, Wang L, Sun B, Ma J, Zheng C, Sun J, Tian Z, Yang X, Xiao W
    Mol Cancer, 2014;13(0):84.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  88. Human adipose-derived stromal/stem cells induce functional CD4+CD25+FoxP3+CD127- regulatory T cells under low oxygen culture conditions.
    Authors: Frazier T, McLachlan J, Gimble J, Tucker H, Rowan B
    Stem Cells Dev, 2014;23(9):968-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  89. The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs.
    Authors: Shi L, Zhang Z, Yu A, Wang W, Wei Z, Akhter E, Maurer K, Costa Reis P, Song L, Petri M, Sullivan K
    PLoS ONE, 2014;9(5):e93846.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  90. CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.
    Authors: Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J
    J Immunol, 2014;192(5):2449-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  91. IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model.
    Authors: Chiricozzi, Andrea, Nograles, Kristine, Johnson-Huang, Leanne M, Fuentes-Duculan, Judilyn, Cardinale, Irma, Bonifacio, Kathleen, Gulati, Nicholas, Mitsui, Hiroshi, Guttman-Yassky, Emma, Suarez-Farinas, Mayte, Krueger, James G
    PLoS ONE, 2014;9(2):e90284.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  92. The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
    Authors: van Wilgenburg, Bonnie, Moore, Michael, James, William, Cowley, Sally A
    PLoS ONE, 2014;9(1):e86071.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  93. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.
    Authors: Fairfax B, Humburg P, Makino S, Naranbhai V, Wong D, Lau E, Jostins L, Plant K, Andrews R, McGee C, Knight J
    Science, 2014;343(6175):1246949.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  94. Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
    Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
    Hum Mol Genet, 2013;22(9):1807-15.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Inhibition of hepatitis B virus gene expression and replication by ribonuclease P.
    Authors: Xia, Chuan, Chen, Yuan-Chu, Gong, Hao, Zeng, Wenbo, Vu, Gia-Phon, Trang, Phong, Lu, Sangwei, Wu, Jianguo, Liu, Fenyong
    Mol Ther, 2013;21(5):995-1003.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  96. IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients.
    Authors: Pennino D, Bhavsar P, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham S, Cavani A, Eyerich K, Chung K, Schmidt-Weber C, Eyerich S
    J Allergy Clin Immunol, 2013;131(2):562-70.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  97. The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.
    Authors: Melo, Rossana, Paganoti, Guillher, Dvorak, Ann M, Weller, Peter F
    PLoS ONE, 2013;8(3):e59578.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  98. Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses.
    Authors: Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio P, Marasco D, Albanesi C
    Eur J Immunol, 2013;43(7):1883-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  99. Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes.
    Authors: Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A
    Eur J Immunol, 2013;43(3):793-804.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  100. STAT2 deficiency and susceptibility to viral illness in humans.
    Authors: Hambleton, Sophie, Goodbourn, Stephen, Young, Dan F, Dickinson, Paul, Mohamad, Siti M B, Valappil, Manoj, McGovern, Naomi, Cant, Andrew J, Hackett, Scott J, Ghazal, Peter, Morgan, Neil V, Randall, Richard
    Proc Natl Acad Sci U S A, 2013;110(8):3053-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  101. Differential regulation of interleukin-12 (IL-12)/IL-23 by Tim-3 drives T(H)17 cell development during hepatitis C virus infection.
    Authors: Wang, Jia M, Shi, Lei, Ma, Cheng J, Ji, Xiao J, Ying, Ruo S, Wu, Xiao Y, Wang, Ke S, Li, Guangyu, Moorman, Jonathan, Yao, Zhi Q
    J Virol, 2013;87(8):4372-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  102. IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
    Authors: Zizzo G, Cohen P
    J Immunol, 2013;190(10):5237-46.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  103. A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.
    Authors: Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M
    PLoS ONE, 2013;9(2):e88714.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  104. Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells.
    Authors: Iachininoto M, Nuzzolo E, Bonanno G, Mariotti A, Procoli A, Locatelli F, De Cristofaro R, Rutella S
    Molecules, 2013;18(9):10132-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  105. Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
    Authors: Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S
    J Immunol, 2013;190(8):3959-66.
    Species: Human
    Sample Type: Plasma
    Application: Bioassay
  106. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.
    Authors: Bancerek J, Poss Z, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dolken L, Strobl B, Muller M, Taatjes D, Kovarik P
    Immunity, 2013;38(2):250-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  107. TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
    Authors: Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume M, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T
    Immunology, 2013;139(1):19-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  108. Anti-CD70 immunocytokines for exploitation of interferon-gamma-induced RIP1-dependent necrosis in renal cell carcinoma.
    Authors: Chen P, Nogusa S, Thapa R, Shaller C, Simmons H, Peri S, Adams G, Balachandran S
    PLoS ONE, 2013;8(4):e61446.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  109. p38alpha senses environmental stress to control innate immune responses via mechanistic target of rapamycin.
    Authors: Katholnig K, Kaltenecker C, Hayakawa H, Rosner M, Lassnig C, Zlabinger G, Gaestel M, Muller M, Hengstschlager M, Horl W, Park J, Saemann M, Weichhart T
    J Immunol, 2013;190(4):1519-27.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  110. Regulation of IL-33 expression by IFN-gamma and tumor necrosis factor-alpha in normal human epidermal keratinocytes.
    J. Invest. Dermatol., 2012;132(11):2593-600.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  111. CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates.
    Eur. J. Immunol., 2012;42(8):2019-30.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  112. The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
    Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
    PLoS ONE, 2012;7(6):e38721.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  113. The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
    Authors: Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD
    J. Biol. Chem., 2012;287(31):25964-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  114. Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma.
    Authors: Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M, Ciciarello M, Scambia G, Palumbo A, Locatelli F, De Cristofaro R, Rutella S
    J Transl Med, 2012;10(0):247.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  115. Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
    Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
    PLoS ONE, 2012;7(4):e34965.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  116. Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
    Authors: Kothari H, Rao L, Vankayalapati R, Pendurthi U
    PLoS ONE, 2012;7(9):e45700.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  117. Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
    Gene Ther, 2012;19(10):1035-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  118. Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
    J. Exp. Med., 2012;209(11):2033-47.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  119. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
    Authors: Zizzo G, Hilliard B, Monestier M, Cohen P
    J Immunol, 2012;189(7):3508-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  120. Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts.
    Clin. Cancer Res., 2012;17(9):2819-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  121. Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
    Authors: Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
    Blood, 2012;120(19):4058-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  122. Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis.
    Authors: Carrier Y, Ma HL, Ramon HE, Napierata L, Small C, O'Toole M, Young DA, Fouser LA, Nickerson-Nutter C, Collins M, Dunussi-Joannopoulos K, Medley QG
    J. Invest. Dermatol., 2011;131(12):2428-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  123. Expression and regulation of CCL15 by human airway smooth muscle cells.
    Authors: Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q
    Clin. Exp. Allergy, 2011;42(1):85-94.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  124. Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.
    Authors: Von Bubnoff D, Scheler M, Wilms H, Fimmers R, Bieber T
    J. Immunol., 2011;186(12):6701-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  125. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
    Authors: Shin HS, Xu F, Bagchi A, Herrup E, Wilhelmsen K
    J. Immunol., 2011;186(2):1119-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  126. Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein.
    Authors: Hasegawa H, Thomas HJ, Schooley K, Born TL
    Cytokine, 2011;53(1):74-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  127. Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma.
    Authors: Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C
    PLoS Pathog., 2011;7(4):e1002016.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  128. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha.
    Authors: Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM
    J. Biol. Chem., 2011;286(2):961-75.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  129. B7-h3 augments the inflammatory response and is associated with human sepsis.
    Authors: Zhang G, Wang J, Kelly J
    J. Immunol., 2010;185(6):3677-84.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  130. Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
    Authors: Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y
    Gut, 2010;59(4):531-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  131. IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
    Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Immunol., 2010;184(9):4880-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  132. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
    Authors: Mengshol JA, Golden-Mason L, Arikawa T
    PLoS ONE, 2010;5(3):e9504.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  133. Evidence for altered Wnt signaling in psoriatic skin.
    Authors: Gudjonsson JE, Johnston A, Stoll SW
    J. Invest. Dermatol., 2010;130(7):1849-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  134. IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation.
    Authors: Ghigo E, Barry AO, Pretat L, Al Moussawi K, Desnues B, Capo C, Kornfeld H, Mege JL
    PLoS ONE, 2010;5(10):e13561.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  135. Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy.
    Authors: Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S
    Biomaterials, 2010;31(12):3357-63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  136. Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells.
    Authors: Ghirelli C, Zollinger R, Soumelis V
    Blood, 2010;115(24):5037-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  137. A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
    Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
    Mucosal Immunol, 2010;3(1):40-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  138. Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
    Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
    Clin. Immunol., 2009;133(1):27-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  139. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
    Authors: Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H
    J. Allergy Clin. Immunol., 2009;123(1):179-86.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  140. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
    Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
    J. Exp. Med., 2009;206(1):249-58.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  141. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
    Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2009;39(12):3570-81.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  142. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
    Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
    Circulation, 2009;119(10):1424-32.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  143. Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism.
    Authors: Semiramoth N, Gleizes A, Turbica I, Sandre C, Gorges R, Kansau I, Servin A, Chollet-Martin S
    J. Leukoc. Biol., 2009;85(2):310-21.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  144. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
    Authors: Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K
    Genes Immun., 2009;10(8):702-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  145. Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease.
    Authors: Lee WI, Liang FC, Huang JL, Jaing TH, Wang CH, Lin TY, Huang YC, Huang WL, Jou R, Hsieh MY, Chia JH, Wu TL
    J. Clin. Immunol., 2009;29(3):319-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  146. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils.
    Authors: Rahmoun M, Moles JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pene J
    J. Invest. Dermatol., 2009;129(3):671-81.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  147. Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.
    Authors: Schwinn N, Vokhminova D, Sucker A, Textor S, Striegel S, Moll I, Nausch N, Tuettenberg J, Steinle A, Cerwenka A, Schadendorf D, Paschen A
    Int. J. Cancer, 2009;124(7):1594-604.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  148. Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells.
    Authors: Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H
    Clin. Exp. Immunol., 2009;155(2):266-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  149. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
    Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
    Invest. Ophthalmol. Vis. Sci., 2009;50(6):2702-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  150. Interleukin-32 expression in the pancreas.
    Authors: Nishida A, Andoh A, Inatomi O, Fujiyama Y
    J. Biol. Chem., 2009;284(26):17868-76.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  151. Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells.
    Authors: Hao Q, Wang L, Tang H
    Am. J. Physiol., Cell Physiol., 2009;296(4):C821-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  152. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
    Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
    Eur. J. Immunol., 2008;38(4):1012-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  153. Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis.
    Authors: Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG
    J. Immunol., 2008;181(10):7420-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  154. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008;24(3):453-62.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  155. Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
    Authors: Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
    J. Immunol., 2008;180(2):1268-75.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  156. Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation.
    Authors: Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K
    Clin. Exp. Immunol., 2008;154(3):384-90.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  157. C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.
    Authors: Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F
    J. Leukoc. Biol., 2008;84(4):1109-19.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  158. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.
    Authors: Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R
    J. Leukoc. Biol., 2008;83(5):1181-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  159. The role of interleukin-22 in hepatitis C virus infection.
    Authors: Dambacher J, Beigel F, Zitzmann K, Heeg MH, Goke B, Diepolder HM, Auernhammer CJ, Brand S
    Cytokine, 2008;41(3):209-16.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  160. Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma.
    Authors: Wente MN, Gaida MM, Mayer C, Michalski CW, Haag N, Giese T, Felix K, Bergmann F, Giese NA, Friess H
    Int. J. Oncol., 2008;33(2):297-308.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  161. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
    Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
    J. Allergy Clin. Immunol., 2008;121(6):1385-92, 1392.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  162. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis.
    Authors: Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL, Prat A
    J. Neurosci., 2007;27(34):9032-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  163. Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.
    Authors: Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A
    J. Immunol., 2007;178(12):8064-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  164. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
    Authors: Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A
    Clin. Exp. Immunol., 2007;149(3):480-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  165. Complement receptor 3 blockade promotes IL-12-Mediated Clearance of Porphyromonas gingivalis and Negates Its Virulence In Vivo.
    Authors: Hajishengallis G, Shakhatreh MA, Wang M, Liang S
    J. Immunol., 2007;179(4):2359-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  166. Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway.
    Authors: Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2007;210(1):192-200.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  167. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
    Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
    AIDS, 2007;21(10):1263-72.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  168. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
    Authors: Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
    J. Leukoc. Biol., 2007;82(4):946-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  169. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
    Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
    J. Biol. Chem., 2007;282(43):31643-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  170. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
    Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
    J. Immunol., 2007;179(2):1080-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  171. Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
    Authors: Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S
    Gut, 2007;56(9):1257-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  172. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007;109(10):4272-9.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  173. Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines.
    Authors: Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA
    Clin. Chem., 2007;53(11):2010-2.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  174. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes.
    Authors: Kanda N, Watanabe S
    Endocrinology, 2007;148(5):2317-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  175. IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.
    Authors: Dame TM, Orenzoff BL, Palmer LE, Furie MB
    J. Immunol., 2007;178(2):1172-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  176. Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury.
    Authors: Parmley LA, Elkins ND, Fini MA, Liu YE, Repine JE, Wright RM
    Br. J. Pharmacol., 2007;152(6):915-29.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  177. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
    Authors: Sa SM, Valdez PA, Wu J
    J. Immunol., 2007;178(4):2229-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  178. Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients.
    Authors: Oates JC, Farrelly LW, Hofbauer AF, Wang W, Gilkeson GS
    Arthritis Rheum., 2007;56(11):3738-47.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  179. HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
    Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
    Glia, 2006;54(6):619-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  180. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
    Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2006;36(5):1309-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  181. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
    Authors: Ebert EC, Mehta V
    Cell. Immunol., 2006;241(1):7-13.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  182. ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naive CD4+ T cells.
    Authors: Mesturini R, Nicola S, Chiocchetti A, Bernardone IS, Castelli L, Bensi T, Ferretti M, Comi C, Dong C, Rojo JM, Yagi J, Dianzani U
    Eur. J. Immunol., 2006;36(10):2601-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  183. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
    Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
    J. Exp. Med., 2006;203(12):2763-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  184. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
    Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
    J. Endocrinol., 2006;191(1):65-81.
    Species: Hamster
    Sample Type: Whole Cells
    Application: Bioassay
  185. Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
    Authors: Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY
    Immunol. Lett., 2006;105(2):159-66.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  186. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
    Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
    Blood, 2006;108(3):947-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  187. Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation.
    Authors: Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR
    J. Neurosci., 2006;26(47):12174-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  188. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines.
    Authors: Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B
    Clin. Immunol., 2006;120(2):220-31.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  189. Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis.
    Authors: Wan B, Nie H, Liu A, Feng G, He D, Xu R, Zhang Q, Dong C, Zhang JZ
    J. Immunol., 2006;177(12):8844-50.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  190. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
    Authors: Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
    J. Immunol., 2006;177(11):7665-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  191. Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage.
    Authors: Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S
    Crit. Care Med., 2005;33(6):1359-64.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  192. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
    Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
    Arthritis Rheum., 2005;52(5):1504-16.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  193. Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases.
    Authors: Scapini P, Carletto A, Nardelli B, Calzetti F, Roschke V, Merigo F, Tamassia N, Pieropan S, Biasi D, Sbarbati A, Sozzani S, Bambara L, Cassatella MA
    Blood, 2005;105(2):830-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  194. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
    Authors: Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME
    J. Virol., 2005;79(20):12828-39.
  195. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
    Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
    Arthritis Rheum., 2005;52(3):770-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  196. Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle.
    Authors: Ameredes BT, Calhoun WJ
    J. Allergy Clin. Immunol., 2005;116(1):65-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  197. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor.
    Authors: Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM
    Biochem. J., 2004;380(0):425-33.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  198. Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.
    Authors: Radstake TR, Roelofs MF, Jenniskens YM, van Riel PL, Barrera P
    Arthritis Rheum., 2004;50(12):3856-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  199. IL-22 increases the innate immunity of tissues.
    Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
    Immunity, 2004;21(2):241-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  200. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.
    Authors: Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC
    J. Exp. Med., 2004;200(11):1419-26.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  201. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis.
    Authors: Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K, Keicho N
    Blood, 2004;103(3):1089-98.
    Species: Human
    Sample Type:
    Application: Binding Assay
  202. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  203. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
    Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
    Blood, 2004;104(2):314-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  204. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004;30(6):816-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  205. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.
    Authors: Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC
    J. Exp. Med., 2004;200(11):1419-26.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  206. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
    Authors: Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A
    J. Immunol., 2004;173(9):5810-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  207. TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia.
    Authors: Ryan LA, Peng H, Erichsen DA, Huang Y, Persidsky Y, Zhou Y, Gendelman HE, Zheng J
    J. Neuroimmunol., 2004;148(1):127-39.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  208. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
    Authors: Copeland S, Siddiqui J, Remick D
    J. Immunol. Methods, 2004;284(1):99-106.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  209. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
    Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
    J. Clin. Invest., 2003;112(4):598-607.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  210. In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.
    Authors: Durali D, de Goer de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y
    Blood, 2003;102(12):4084-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  211. The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma.
    Authors: Borchmann P, Treml JF, Hansen H, Gottstein C, Schnell R, Staak O, Zhang HF, Davis T, Keler T, Diehl V, Graziano RF, Engert A
    Blood, 2003;102(10):3737-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  212. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
    Authors: Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T
    Proc. Natl. Acad. Sci. U.S.A., 2003;100(16):9452-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  213. HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection.
    Authors: Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos GP, Kino T
    J. Immunol., 2002;169(11):6361-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  214. Expression of CTLA-4 by human monocytes.
    Authors: Wang XB, Giscombe R, Yan Z
    Scand. J. Immunol., 2002;55(1):53-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  215. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
    Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
    Blood, 1996;88(6):2013-25.
    Species: Human
    Sample Type:
    Application: Bioassay
  216. Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1.
    Authors: Wang R, Jaw JJ, Jaw J, Stutzman N, Stutzman NC, Zou Z, Sun PD
    J Leukoc Biol, 0;91(2):299-309.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  217. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
    Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
    J Biol Chem, 0;284(36):24035-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
Expand to show all 217 Citations
Animal-Free Recombinant Proteins
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Recombinant Human IFN-gamma, Animal-Free Protein

BA AFL285
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Average Rating: 4.4 (Based on 5 reviews)

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We have 4 reviews tested in 2 applications: In vitro bioactivity in cell culture, In vivo study.
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  Very Good
  Anonymous 04/26/2017
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 In vitro bioactivity in cell culture Anonymous 07/21/2016
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Summary

ApplicationIn vitro bioactivity in cell culture
Reason for RatingThe IFN-g was excellent in stimulating whole blood.

Other Experimental Details

Other Experimental DetailsIFN-g was used to stimulate whole blood. 100ng/mL final concentration was used in 1mL whole blood for 15 minutes at 37C. The cells were fixed and stored in -80C until further analysis on CyTOF
In vivo study Recombinant Human IFN-gamma Protein 285-IF
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 In vivo study Anonymous 07/13/2016
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In vivo study Recombinant Human IFN-gamma Protein 285-IF
In vivo study: Recombinant Human IFN-gamma Protein [285-IF]

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ApplicationIn vivo study

Other Experimental Details

Other Experimental DetailsIFN-gamma treatment (solid line) induces HLA-DR expression in cultured MSC as compared to control cells (filled histogram).
  Very Good
 In vitro bioactivity in cell culture Anonymous 05/31/2016
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ApplicationIn vitro bioactivity in cell culture
  Very Good
 In vitro bioactivity in cell culture Anonymous 01/21/2016
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ApplicationIn vitro bioactivity in cell culture

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