Chemical Name: 1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt
Biological ActivityHighly potent P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel (Cat. No. 2490), does not require bioactivation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor.
Hoffmann et al.
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.
Baqi et al.
Development of a comprehensive set of P2 receptor pharmacological research compounds.
Felix et al.
Citations for PSB 0739
The citations listed below are publications that use Tocris products. Selected citations for PSB 0739 include:
9 Citations: Showing 1 - 9
Microglia Monitor and Protect Neuronal Function Through Specialized Somatic Purinergic Junctions.
Authors: Cserép Et al.
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Authors: Uderhardt Et al.
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
Authors: Madry Et al.
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
Authors: Abud Et al.
Protease-activated receptor-4 and P2Y12 Dimerize, Co-Internalize and Activate Akt Signaling via Endosomal Recruitment of β-arrestin.
Authors: Smith Et al.
J Biol Chem 2017;
Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system
Authors: Takayama Et al.
Scientific Reports 2016;6:30006
Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Authors: Aungraheeta Et al.
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
Authors: Wang Et al.
PLoS One 2014;9:e110101
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H20; dilution 10 μM
Used to block P2Y12 in acute brain slices. Monitored was the motility of microglia. No significant effect was found.