Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

DyLight 350 (Excitation = 353 nm, Emission = 432 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 665521
View all PSENEN Primary Antibodies »

Product Specifications

Immunogen

Peptide containing human PSENEN
Gly89-Gly98
Accession # Q9NZ42

Specificity

Detects human PSENEN in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for PSENEN/PEN2 Antibody (665521) [DyLight 350]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PSENEN

Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.

Long Name

Presenilin Enhancer 2 Homolog

Alternate Names

PEN-2

Gene Symbol

PSENEN

Additional PSENEN Products

Product Documents for PSENEN/PEN2 Antibody (665521) [DyLight 350]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PSENEN/PEN2 Antibody (665521) [DyLight 350]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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