Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG2B Clone # 436502
View all PTP mu/PTPRM Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human PTPμ/PTPRM
Glu21-Lys742
Accession # P28827

Specificity

Detects human, mouse, and rat PTPμ/PTPRM in Western blots. In Western blots, no cross-reactivity with recombinant human PTPRK, PTPRT, PTPRD, PTPRG, PTPRF (LAR), or DEP1 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for PTP mu/PTPRM Antibody (436502) [Biotin]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PTP mu/PTPRM

PTPRM is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

Long Name

Protein Tyrosine Phosphatase Receptor-type M

Alternate Names

PTPRL1, PTPRM, R-PTP-mu

Gene Symbol

PTPRM

Additional PTP mu/PTPRM Products

Product Documents for PTP mu/PTPRM Antibody (436502) [Biotin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for PTP mu/PTPRM Antibody (436502) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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