Purvalanol B

Key Product Details

Product Description

Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC₅₀ >10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).

Licensing Information

Sold under license from the Regents of the University of California

Product Specifications for Purvalanol B

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Purvalanol B

The following data is based on the product molecular weight 432.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.55 mL	23.10 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Ozfiliz-Kilbas Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells. Mol.Biol.Rep. 2018 PMID: 29978381
• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Gray ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 1999 PMID: 10495356
• Knockaert p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene 2002 PMID: 12226745
• Gray Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 1998 PMID: 9677190

Product Documents for Purvalanol B