Purvalanol B

Catalog # Availability Size / Price Qty
Purvalanol B | CAS No. 212844-54-7 | Cyclin-dependent Kinase Inhibitors
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Description: Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names: NG 95

Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purity: ≥99%

Product Details
Citations (3)

Biological Activity

Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 >10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).

Technical Data

Soluble to 100 mM in 1eq. NaOH with gentle warming and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Regents of the University of California

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Citations for Purvalanol B

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