Catalog Number: 1581
Alternate Names: NG 95
Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Biological Activity
Cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.
Technical Data
  • M.Wt:
    432.91
  • Formula:
    C20H25ClN6O3
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    212844-54-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the Regents of the University of California
Background References
  1. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
    Gray et al.
    Science, 1998;281:533
  2. ATP-site directed inhibitors of cyclin-dependent kinases.
    Gray et al.
    Curr.Med.Chem., 1999;6:859
  3. p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
    Knockaert et al.
    Oncogene, 2002;21:6413
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Purvalanol B include:

2 Citations: Showing 1 - 2
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  1. An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling.
    Authors: Schreiber Et al.
    Mol Cell Proteomics 2010;9:1047
  2. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
    Authors: Wissing Et al.
    J Pharmacol Exp Ther 2007;6:537

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