Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Biological ActivityPurvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Selective over a range of other protein kinases (IC50 >10,000 nM). Shown to have antiproliferative properties, mediated by ERK1 and ERK2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Gray et al.
ATP-site directed inhibitors of cyclin-dependent kinases.
Gray et al.
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Knockaert et al.
Citations for Purvalanol B
The citations listed below are publications that use Tocris products. Selected citations for Purvalanol B include:
3 Citations: Showing 1 - 3
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.
Authors: Ma Et al.
Nat Commun 2019;10:296
An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling.
Authors: Schreiber Et al.
Mol Cell Proteomics 2010;9:1047
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Authors: Wissing Et al.
J Pharmacol Exp Ther 2007;6:537
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