Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Biological ActivityPurvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 >10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Gray et al.
ATP-site directed inhibitors of cyclin-dependent kinases.
Gray et al.
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Knockaert et al.
Citations for Purvalanol B
The citations listed below are publications that use Tocris products. Selected citations for Purvalanol B include:
3 Citations: Showing 1 - 3
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.
Authors: Ma Et al.
Nat Commun 2019;10:296
An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling.
Authors: Schreiber Et al.
Mol Cell Proteomics 2010;9:1047
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Authors: Wissing Et al.
J Pharmacol Exp Ther 2007;6:537
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