Purvalanol B

Catalog # Availability Size / Price Qty
1581/10
1581/50
Purvalanol B | CAS No. 212844-54-7 | Cyclin-dependent Kinase Inhibitors
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Description: Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names: NG 95

Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purity: ≥99%

Product Details
Citations (3)
Reviews

Biological Activity

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Selective over a range of other protein kinases (IC50 >10,000 nM). Shown to have antiproliferative properties, mediated by ERK1 and ERK2.

Technical Data

M.Wt:
432.91
Formula:
C20H25ClN6O3
Solubility:
Soluble to 100 mM in 1eq. NaOH with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
212844-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Regents of the University of California

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Citations for Purvalanol B

The citations listed below are publications that use Tocris products. Selected citations for Purvalanol B include:

3 Citations: Showing 1 - 3

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