[Pyr¹]-Apelin-13

Name: [Pyr 1 ]-Apelin-13
Brand: Tocris Bioscience
SKU: 2420
Price: 263 USD
Availability: InStock

Tocris Bioscience | Catalog # 2420

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Citations (6)

Product Documents

Potent peptide apelin agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent peptide apelin agonist

Alternative Names

[pGlu¹]-Apelin-13

View all Apelin Receptor Agonists »

Product Description

[Pyr¹]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC₅₀ = 0.37 nM) that displays potent vascular effects in vivo.

Product Specifications for [Pyr¹]-Apelin-13

Molecular Weight

1533.81

Formula

C₆₉H₁₀₈N₂₂O₁₆S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

217082-60-5

PubChem ID

25085173

InChI Key

GGMAXEWLXWJGSF-PEWBXTNBSA-N

SMILES

[H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Kleinz Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 2005 PMID: 15907343
Kagiyama Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 2005 PMID: 15582714
Tatemoto Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm.
Katugampola [¹²⁵I]-(Pyr¹)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 2001 PMID: 11250876

Product Documents for [Pyr¹]-Apelin-13

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for [Pyr¹]-Apelin-13

For research use only

Related Research Areas

Chemokines and Receptors

Infectious Diseases

Obesity

Citations for [Pyr¹]-Apelin-13

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