Biological Activity[Pyr1]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
(Modifications: X = Glp)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Emerging roles of apelin in biology and medicine.
Kleinz et al.
[125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
Katugampola et al.
Central and peripheral cardiovascular actions of apelin in conscious rats.
Kagiyama et al.
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Tatemoto et al.
Citations for [Pyr1]-Apelin-13
The citations listed below are publications that use Tocris products. Selected citations for [Pyr1]-Apelin-13 include:
2 Citations: Showing 1 - 2
Apelin modulates murine gastric vagal afferent mechanosensitivity.
Physiol Behav 2018;194:466
Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth.
Authors: Hall Et al.
Cancer Lett 2017;386:179
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