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Description: Potent peptide apelin agonist
Alternative Names: [pGlu1]-Apelin-13

Purity: ≥95%

Product Details
Citations (2)
Supplemental Products

Biological Activity

[Pyr1]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.

Technical Data


(Modifications: X = Glp)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Emerging roles of apelin in biology and medicine.
    Kleinz et al.
    Pharmacol.Ther., 2005;107:198
  2. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
    Katugampola et al.
    Br.J.Pharmacol., 2001;132:1255
  3. Central and peripheral cardiovascular actions of apelin in conscious rats.
    Kagiyama et al.
    Regul.Pept., 2005;125:55
  4. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
    Tatemoto et al.
    Biochem.Biophys.Res.Comms., 1998;251:471

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Citations for [Pyr1]-Apelin-13

The citations listed below are publications that use Tocris products. Selected citations for [Pyr1]-Apelin-13 include:

2 Citations: Showing 1 - 2


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