Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50
= 0.37 nM) that displays potent vascular effects in vivo
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[125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
Katugampola et al.
Central and peripheral cardiovascular actions of apelin in conscious rats.
Kagiyama et al.
Emerging roles of apelin in biology and medicine.
Kleinz et al.
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Tatemoto et al.