Catalog Number: 2420
Alternate Names: [pGlu1]-Apelin-13
Biological Activity
Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
Technical Data
  • M.Wt:
    1533.81
  • Formula:
    C69H108N22O16S
  • Sequence:
    XRPRLSHKGPMPF

    (Modifications: X = Glp)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    217082-60-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
    Katugampola et al.
    Br.J.Pharmacol., 2001;132:1255
  2. Central and peripheral cardiovascular actions of apelin in conscious rats.
    Kagiyama et al.
    Regul.Pept., 2005;125:55
  3. Emerging roles of apelin in biology and medicine.
    Kleinz et al.
    Pharmacol.Ther., 2005;107:198
  4. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
    Tatemoto et al.
    Biochem.Biophys.Res.Comm., 1998;251:471

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