CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
Quantikine Immunoassay Control Set 1064 for Human HS CTLA-4
R&D Systems | Catalog # QC283
For use with catalog number HSCT40
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Key Product Details
Species
Human
Applications
Control
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Background: CTLA-4
Long Name
Cytotoxic T-lymphocyte-associated Molecule 4
Alternate Names
CD152, CTLA4
Gene Symbol
CTLA4
Additional CTLA-4 Products
Product Documents for Quantikine Immunoassay Control Set 1064 for Human HS CTLA-4
Certificate of Analysis
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Product Specific Notices for Quantikine Immunoassay Control Set 1064 for Human HS CTLA-4
For research use only
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