R-96544 hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:1742
Chemical Name:(2R,4R)-5-[2-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinol hydrochloride
Product Details
Citations (3)
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Reviews
Biological Activity
Potent, selective 5-HT2 receptor antagonist; displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM). IC50 values are 2.2, 310, 2400, 3700, > 5000 and > 5000 nM for 5-HT2, α1-adrenergic, D2 dopamine, 5-HT1, 5-HT3 and β-adrenergic receptors respectively. Inhibits 5-HT-induced platelet aggregation and pressor responses in vivo.
Technical Data
  • M.Wt:
    391.94
  • Formula:
    C22H29NO3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    167144-80-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for R-96544 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
    Authors: Chien and Su
    PLoS One  2015;22:42
  2. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells.
    Authors: Tanaka Et al.
    J Biol Chem  2014;289:10466
  3. Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome.
    Authors: Xu Et al.
    J Pharmacol Exp Ther  2012;7:e48741

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