(R)-(+)-Bay K 8644

Catalog # Availability Size / Price Qty
(R)-(+)-Bay K 8644 | CAS No. 98791-67-4 | Cav1.x Channel Blockers
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Description: CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor

Chemical Name: (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

Purity: ≥97%

Product Details
Citations (1)

Biological Activity

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citation for (R)-(+)-Bay K 8644

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