(R)-(+)-Bay K 8644

Catalog # Availability Size / Price Qty
1545/10
1545/50
(R)-(+)-Bay K 8644 | CAS No. 98791-67-4 | Cav1.x Channel Blockers
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Description: CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor

Chemical Name: (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Technical Data

M.Wt:
356.3
Formula:
C16H15F3N2O4
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
98791-67-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for (R)-(+)-Bay K 8644

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