(R)-CPP

Tocris Bioscience | Catalog # 0247

Potent NMDA antagonist; more active enantiomer of (RS)-CPP
Tocris Bioscience

Key Product Details

Description

Potent NMDA antagonist; more active enantiomer of (RS)-CPP
View all NMDA Receptor Antagonists »

Product Description

(R)-CPP is a highly potent NMDA antagonist; more active isomer. Shows some selectivity for GluN2A (formally NR2A) containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of GluN2A-, GluN2B-, GluN2C- and GluN2D-containing recombinant NMDA receptors respectively).

Racemate also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for (R)-CPP

Molecular Weight

252.21

Formula

C8H17N2O5P

Storage

Desiccate at RT

Chemical Name

3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid

CAS Number

126453-07-4

PubChem ID

6603754

InChI Key

CUVGUPIVTLGRGI-SSDOTTSWSA-N

SMILES

[H][C@@]1([C@](O)=O)NCCN(CCCP(O)(O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.22 100

Preparing Stock Solutions for (R)-CPP

The following data is based on the product molecular weight 252.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.82 mL 39.65 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
10 mM 0.40 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.40 mL 0.79 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 162 publications citing the usage of this product.

Product Documents for (R)-CPP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-CPP

For research use only

Customer Reviews for (R)-CPP (1)

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  • CPP action on human neutrophils
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Blood
    Verified Customer | Posted 07/13/2023
    (R)-CPP was used to quantify the input of Ca2+ flow through NMDA receptors into Ca2+ concentration fluctuations in human neutrophils. Figure: impact of (R)-CPP on Ca2+ - induced fluorescence in cultured neutrophils (+CPP bar).
    (R)-CPP 0247

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