(R)-CPP

  ( 7 citations )    
Product Datasheet
Catalog Number:0247
Chemical Name:3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Product Details
Citations (7)
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Reviews
Biological Activity
Highly potent NMDA antagonist; more active isomer. Shows some selectivity for GluN2A (formally NR2A) containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of GluN2A-, GluN2B-, GluN2C- and GluN2D-containing recombinant NMDA receptors respectively).

Racemate also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data
  • M.Wt:
    252.21
  • Formula:
    C8H17N2O5P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    126453-07-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-CPP include:

7 Citations: Showing 1 - 7
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  1. Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators.
    Authors: Mao Et al.
    Nat Commun  ;3:e1796
  2. Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
    Authors: Pan Et al.
    J Clin Invest  2016;126:4516
  3. Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
    Authors: Tsutsui-Kimura Et al.
    J Neurosci  2015;18
  4. Plasticity of binocularity and visual acuity are differentially limited by nogo receptor.
    Authors: Stephany Et al.
    PLoS One  2014;34:11631
  5. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One  2011;6:e19155
  6. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
    Authors: Wood Et al.
    Int J Neuropsychopharmacol  2009;29:12440
  7. Differential compartmentalization and distinct functions of GABAB receptor variants.
    Authors: Vigot Et al.
    Neuron  2006;50:589

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(RS)-CPP

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