Chemical Name: 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Biological ActivityHighly potent NMDA antagonist; more active isomer. Shows some selectivity for GluN2A (formally NR2A) containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of GluN2A-, GluN2B-, GluN2C- and GluN2D-containing recombinant NMDA receptors respectively).
Racemate also available.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.
Feng et al.
Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene).
Aebischer et al.
Citations for (R)-CPP
The citations listed below are publications that use Tocris products. Selected citations for (R)-CPP include:
14 Citations: Showing 1 - 10
Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators.
Authors: Mao Et al.
Nat Commun ;3:e1796
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Authors: Collins Et al.
Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
Authors: Chang and Higley
Physiol Rep 2018;6:e13747
Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.
Authors: Sancho and Bloodgood
Cell Rep 2018;24:2075
Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
Authors: Zhang Et al.
The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival.
Authors: Maeder Et al.
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Authors: Fan Et al.
Nat Methods 2018;15:823
A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.
Authors: Chaffiol Et al.
Mol Ther 2017;25:2546
Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
Authors: Pan Et al.
J Clin Invest 2016;126:4516
Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
Authors: Tsutsui-Kimura Et al.
J Neurosci 2015;18
Plasticity of binocularity and visual acuity are differentially limited by nogo receptor.
Authors: Stephany Et al.
PLoS One 2014;34:11631
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
Authors: Higley Et al.
PLoS One 2011;6:e19155
Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
Authors: Wood Et al.
Int J Neuropsychopharmacol 2009;29:12440
Differential compartmentalization and distinct functions of GABAB receptor variants.
Authors: Vigot Et al.
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