Catalog Number: 0173
Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Biological Activity
Potent NMDA antagonist. Separate isomer (R)-CPP also available (Cat. No. 0247).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]-D-AP5 binding sites on brain membranes and anti-convulsant activity.
    Davies et al.
    Brain Res., 1986;382:169

The citations listed below are publications that use Tocris products. Selected citations for (RS)-CPP include:

Showing Results 1 - 10 of 19

  1. Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.
    Authors: Maag Et al.
    Front Neurosci
  2. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
    Authors: Ferreira Et al.
    Front Cell Neurosci
  3. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
  4. Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
    Authors: Hooks Et al.
    J Neurosci
  5. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci
  6. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory.
    Authors: Neuner Et al.
    Behav Brain Res
  7. Step-by-step instructions for retina recordings with perforated multi electrode arrays.
    Authors: Reinhard Et al.
    PLoS One
  8. Modeling the dynamic interaction of Hebbian and homeostatic plasticity.
    Authors: Toyoizumi Et al.
  9. Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.
    Authors: Vaghi Et al.
    Cereb Cortex
  10. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
    Authors: Viemari Et al.
    Front Neural Circuits
  11. Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
    Authors: Wibrand Et al.
    Eur J Neurosci
  12. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
    Authors: Ben-Mabrouk and Tryba
    Eur J Neurosci
  13. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci
  14. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    J Neurosci
  15. Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.
    Authors: Smith and Otis
    Proc Natl Acad Sci U S A
  16. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci
  17. Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.
    Authors: Abraham Et al.
    Proc Natl Acad Sci U S A
  18. Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation.
    Authors: Sacktor Et al.
    Proc Natl Acad Sci U S A
  19. Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
    Authors: Tacconi Et al.
    Br J Pharmacol
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