Catalog # Availability Size / Price Qty
(RS)-CPP | CAS No. 100828-16-8 | NMDA Receptor Antagonists
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Description: Potent NMDA antagonist

Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid

Product Details
Citations (34)
Reviews (1)

Biological Activity

(RS)-CPP is a potent NMDA antagonist.

R-enantiomer also available.

Technical Data

Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for (RS)-CPP

The citations listed below are publications that use Tocris products. Selected citations for (RS)-CPP include:

34 Citations: Showing 1 - 10

  1. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
    Authors: Birdsong Et al.
    Elife  2019;8
  2. OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
    Authors: Xiao Et al.
    Elife  2018;7
  3. In Vivo Regulation of Oligodendrocyte Precursor Cell Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2.
    Authors: Chen Et al.
    Cell Rep  2018;25:852
  4. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  5. Biased OXTergic Modulation of Midbrain DA Systems.
    Authors: Xiao Et al.
    Neuron  2017;95:368
  6. Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy.
    Authors: Pollak Et al.
    PLoS One  2017;12:e0172884
  7. Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors
    Authors: Voyer
    Neuropharmacology  2017;112:150
  8. Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.
    Authors: Maag Et al.
    Front Neurosci  2015;9:351
  9. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
    Authors: Ferreira Et al.
    Front Cell Neurosci  2015;9:161
  10. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Elife  2015;4
  11. Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
    Authors: Hooks Et al.
    J Neurosci  2015;35:4418
  12. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci  2015;35:308
  13. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory.
    Authors: Neuner Et al.
    Behav Brain Res  2015;281:69
  14. Step-by-step instructions for retina recordings with perforated multi electrode arrays.
    Authors: Reinhard Et al.
    PLoS One  2014;9:e106148
  15. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion.
    Authors: Armbruster Et al.
    Front Cell Neurosci  2014;8:277
  16. Modeling the dynamic interaction of Hebbian and homeostatic plasticity.
    Authors: Toyoizumi Et al.
    Neuron  2014;84:497
  17. Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.
    Authors: Vaghi Et al.
    Cereb Cortex  2014;24:1247
  18. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
    Authors: Zhao
    J Neurophysiol  2014;111:1008
  19. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
    Authors: Viemari Et al.
    Front Neural Circuits  2013;7:179
  20. Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.
    Authors: Messer and Levine
    J Neurosci Res  2012;90:1454
  21. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro.
    Authors: Viemari Et al.
    Eur J Neurosci  2011;33:2228
  22. Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
    Authors: Wibrand Et al.
    Eur J Neurosci  2010;31:636
  23. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
    Authors: Ben-Mabrouk and Tryba
    Eur J Neurosci  2010;31:1219
  24. Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.
    Authors: Gaier Et al.
    J Neurosci  2010;30:13656
  25. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
    Authors: Guo and Rainnie
    Neuroscience  2010;165:1390
  26. Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons.
    Authors: Logan Et al.
    J Neurophysiol  2007;98:2693
  27. Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
    Authors: Bloodgood and Sabatini
    Neuron  2007;53:249
  28. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci  2007;10:321
  29. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    J Neurosci  2005;25:5502
  30. Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.
    Authors: Smith and Otis
    Proc Natl Acad Sci U S A  2005;102:14901
  31. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci  2004;24:4551
  32. Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.
    Authors: Abraham Et al.
    Proc Natl Acad Sci U S A  2001;98:10924
  33. Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation.
    Authors: Sacktor Et al.
    Proc Natl Acad Sci U S A  1993;90:8342
  34. Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
    Authors: Tacconi Et al.
    Br J Pharmacol  1993;108:577


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Inhibition of Synaptic Transmission in the VP
By Anonymous on 02/02/2020
Application: Species: Mouse

CPP 5 mM

PMID: 29949769

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