Catalog Number: 0173
Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Biological Activity
Potent NMDA antagonist.

R-enantiomer also available.

Technical Data
  • M.Wt:
    252.21
  • Formula:
    C8H17N2O5P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    100828-16-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]-D-AP5 binding sites on brain membranes and anti-convulsant activity.
    Davies et al.
    Brain Res., 1986;382:169
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-CPP include:

20 Citations: Showing 1 - 10
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  1. Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors
    Authors: Voyer
    Neuropharmacology 2017;112:150
  2. Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.
    Authors: Maag Et al.
    Front Neurosci 2015;9:351
  3. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
    Authors: Ferreira Et al.
    Front Cell Neurosci 2015;9:161
  4. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Elife 2015;4
  5. Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
    Authors: Hooks Et al.
    J Neurosci 2015;35:4418
  6. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci 2015;35:308
  7. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory.
    Authors: Neuner Et al.
    Behav Brain Res 2015;281:69
  8. Step-by-step instructions for retina recordings with perforated multi electrode arrays.
    Authors: Reinhard Et al.
    PLoS One 2014;9:e106148
  9. Modeling the dynamic interaction of Hebbian and homeostatic plasticity.
    Authors: Toyoizumi Et al.
    Neuron 2014;84:497
  10. Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.
    Authors: Vaghi Et al.
    Cereb Cortex 2014;24:1247
  11. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
    Authors: Viemari Et al.
    Front Neural Circuits 2013;7:179
  12. Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
    Authors: Wibrand Et al.
    Eur J Neurosci 2010;31:636
  13. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
    Authors: Ben-Mabrouk and Tryba
    Eur J Neurosci 2010;31:1219
  14. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci 2007;10:321
  15. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    J Neurosci 2005;25:5502
  16. Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.
    Authors: Smith and Otis
    Proc Natl Acad Sci U S A 2005;102:14901
  17. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci 2004;24:4551
  18. Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.
    Authors: Abraham Et al.
    Proc Natl Acad Sci U S A 2001;98:10924
  19. Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation.
    Authors: Sacktor Et al.
    Proc Natl Acad Sci U S A 1993;90:8342
  20. Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
    Authors: Tacconi Et al.
    Br J Pharmacol 1993;108:577
Expand to show all 20 Citations

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