Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Biological ActivityPotent NMDA antagonist.
R-enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for (RS)-CPP
The citations listed below are publications that use Tocris products. Selected citations for (RS)-CPP include:
34 Citations: Showing 1 - 10
Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
Authors: Birdsong Et al.
OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
Authors: Xiao Et al.
In Vivo Regulation of Oligodendrocyte Precursor Cell Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2.
Authors: Chen Et al.
Cell Rep 2018;25:852
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
Biased OXTergic Modulation of Midbrain DA Systems.
Authors: Xiao Et al.
Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy.
Authors: Pollak Et al.
PLoS One 2017;12:e0172884
Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors
Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.
Authors: Maag Et al.
Front Neurosci 2015;9:351
Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
Authors: Ferreira Et al.
Front Cell Neurosci 2015;9:161
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Authors: Saunders Et al.
Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
Authors: Hooks Et al.
J Neurosci 2015;35:4418
Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Authors: Zhao Et al.
J Neurosci 2015;35:308
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory.
Authors: Neuner Et al.
Behav Brain Res 2015;281:69
Step-by-step instructions for retina recordings with perforated multi electrode arrays.
Authors: Reinhard Et al.
PLoS One 2014;9:e106148
Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion.
Authors: Armbruster Et al.
Front Cell Neurosci 2014;8:277
Modeling the dynamic interaction of Hebbian and homeostatic plasticity.
Authors: Toyoizumi Et al.
Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.
Authors: Vaghi Et al.
Cereb Cortex 2014;24:1247
BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
J Neurophysiol 2014;111:1008
β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
Authors: Viemari Et al.
Front Neural Circuits 2013;7:179
Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.
Authors: Messer and Levine
J Neurosci Res 2012;90:1454
Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro.
Authors: Viemari Et al.
Eur J Neurosci 2011;33:2228
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
Authors: Wibrand Et al.
Eur J Neurosci 2010;31:636
Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
Authors: Ben-Mabrouk and Tryba
Eur J Neurosci 2010;31:1219
Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.
Authors: Gaier Et al.
J Neurosci 2010;30:13656
Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
Authors: Guo and Rainnie
Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons.
Authors: Logan Et al.
J Neurophysiol 2007;98:2693
Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
Authors: Bloodgood and Sabatini
Vesicular release of glutamate from unmyelinated axons in white matter.
Authors: Ziskin Et al.
Nat Neurosci 2007;10:321
Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
J Neurosci 2005;25:5502
Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.
Authors: Smith and Otis
Proc Natl Acad Sci U S A 2005;102:14901
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Authors: Huang Et al.
J Neurosci 2004;24:4551
Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.
Authors: Abraham Et al.
Proc Natl Acad Sci U S A 2001;98:10924
Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation.
Authors: Sacktor Et al.
Proc Natl Acad Sci U S A 1993;90:8342
Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
Authors: Tacconi Et al.
Br J Pharmacol 1993;108:577
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CPP 5 mM