RA 2

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RA 2 | CAS No. 1867107-62-7 | Ca2+-Activated Potassium Channel Modulators
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Description: Potent negative modulator of KCa2.3 and KCa3.1 channels

Chemical Name: 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)

Purity: ≥98%

Product Details

Biological Activity

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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