Rat CCL19/MIP‑3 beta Alexa Fluor™ Plus 647‑conjugated Antibody

R&D Systems | Catalog # FAB7800AFP647

R&D Systems

Key Product Details

Species Reactivity

Rat

Applications

Neutralization

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 866202
View all CCL19/MIP-3 beta Primary Antibodies »

Product Specifications

Specificity

Detects rat CCL19/MIP‑3 beta in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Rat CCL19/MIP‑3 beta Alexa Fluor™ Plus 647‑conjugated Antibody

Application
Recommended Usage

Neutralization

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CCL19/MIP-3 beta

CCL19 (also known as Mip-3 beta, ELC, CK beta -11, Scya19 and Exodus-3) is a 9 kDa secreted member of the CC family of chemotactic cytokines (1-4). Cells known to express CCL19 are limited in number, and include activated monocytes (5), stromal cells in nodal T zones (6), CD8+ dendritic cells (DC) (6), vascular endothelial cells (7), visceral smooth muscle and mast cells (8), and thymic stromal cells (9).  Rat CCL19 is synthesized as a precursor that is 1108 amino acids (aa) in length. Mature rat CCL19 shares 72% and 89% aa sequence identity with human and mouse CCL19, respectively. CCL19 is known to bind to CCR7 (3, 4), CCLR2/CRAM (L-CCR in rodent) (10, 11) and CCX-CKR (12), with the last two receptors representing scavenger, or chemokine-sink receptors.

References

  1. Sharma, M. (2010) Crit. Rev. Biotechnol. 30:1.
  2. Blanchet, X. et al. (2012) Front. Immunol. 3:175.
  3. Yoshida, R. et al. (1997) J. Biol. Chem. 272:13803.
  4. Ngo, V.N. et al. (1998) J. Exp. Med. 188:181.
  5. Rossi, D.L. et al. (1997) J. Immunol. 158:1033.
  6. Luther, S.A. et al. (2000) Proc. Natl. Acad. Sci. USA 97:12694.
  7. Alt, C. et al. (2002) Eur. J. Immunol. 32:2133.
  8. Kaur, D. et al. (2006) Am. J. Respir. Crit. Care Med. 174:1179.
  9. Takamura, K. et al. (2007) J. Immunol. 179:5897.
  10. Leick, M. et al. (2009) Immunology 129:536.
  11. Yoshimura, T. & J.J. Oppenheim (2011) Exp. Cell Res. 317:674.
  12. Comerford, I. et al. (2006) Eur. J. Immunol. 36:1904

Alternate Names

ELC, MIP-3 beta, MIP3 beta

Entrez Gene IDs

6363 (Human); 24047 (Mouse); 362506 (Rat)

Gene Symbol

CCL19

UniProt

NP_001102131

Additional CCL19/MIP-3 beta Products

Product Documents for Rat CCL19/MIP‑3 beta Alexa Fluor™ Plus 647‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Rat CCL19/MIP‑3 beta Alexa Fluor™ Plus 647‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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