Recombinant Cynomolgus Monkey PVRIG Fc Chimera Protein, CF

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Recombinant Cynomolgus Monkey PVRIG Fc Chimera Protein Binding Activity.
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Product Details

Recombinant Cynomolgus Monkey PVRIG Fc Chimera Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Cynomolgus Monkey PVRIG Fc Chimera is immobilized at 1.00 µg/mL (100 µL/well), Recombinant Human Nectin-2/CD112 (Catalog # 2229-N2) binds with an ED50 of 0.150-0.750 μg/mL.
Human embryonic kidney cell, HEK293-derived cynomolgus monkey PVRIG protein
Cynomolgus Monkey PVRIG
(Gly20, Ser21 or Glu23-Leu172)
Accession # XP_005549281.1
Accession #
N-terminal Sequence
Gly20, Ser21, Glu23
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
45 kDa
52-63 kDa, under reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Binding Activity View Larger

When Recombinant Cynomolgus Monkey PVRIG Fc Chimera (Catalog # 10718-CV) is immobilized at 1.00 µg/mL (100 µL/well), Recombinant Human Nectin-2/CD112 (2229-N2) binds with an ED50 of 0.150-0.750  μg/mL.

SDS-PAGE View Larger

2 μg/lane of Recombinant Cynomolgus Monkey PVRIG Fc Chimera (Catalog # 10718-PV) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 52-63 kDa and 104-126 kda, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: PVRIG

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family (1). It is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is a potential docking site for phosphatases (1). The extracellular domain sequence of cynomolgus monkey PVRIG have approximately 90% similarity with human PVRIG, respectively. The human PVRIG gene is preferentially expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells (1). PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells (1-3). Blocking PVRIG with neutralizing antibody is a feasible approach for NK cell mediated immunotherapy of cancers (4, 5).

  1. Zhu, Y. et al. (2016) J. Exp. Med. 213:167.
  2. Whelan, S. et al. (2019) Cancer Immunol Res. 7:257.
  3. Murter, B. et al. (2019) Cancer Immunol Res. 7:244.
  4. Li, J. et al. (2020) Haematologica. DOI:10.3324/haematol.2020.258574. 
  5. Sanchez-Correa, B. et al. (2019) Cancers (Basel) 11:877.
Long Name
Poliovirus Receptor Related Immunoglobulin Domain Containing
Entrez Gene IDs
79037 (Human); 102640920 (Mouse); 102127364 (Cynomolgus Monkey)
Alternate Names
C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; poliovirus receptor related immunoglobulin domain containing; Poliovirus receptor-related immunoglobulin domain-containing protein; PVRIG; transmembrane protein PVRIG


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