Recombinant Human CCL2/MCP-1 Protein, CF

  (56 citations)     
Datasheet / CoA / SDS
Product Details
Citations (56)
FAQs
Reviews
  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR2A. The ED50 for this effect is 5‑30 ng/mL.
  • Source
    E. coli-derived human CCL2/JE/MCP-1 protein
    Gln24-Thr99
  • Accession #
  • N-terminal Sequence
    Analysis
    Gln24
  • Predicted Molecular Mass
    8.7 kDa
  • SDS-PAGE
    10 kDa, reducing conditions
Product Datasheets

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Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
279-MC/CF
 
279-MC
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
 
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
 
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
 
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Human CCL2/
MCP-1,  (Catalog # 279-MC/CF) chemoattracts the BaF3 mouse pro-B cell line transfected with human CCR2A. The ED50 for this effect is 5-30 ng/mL.
1 μg/lane of Recombinant Human CCL2/MCP-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 10 kDa.
MALDI-TOF analysis of Recombinant Human CCL2/MCP-1. The major peak corresponds to the calculated molecular mass, 8679 Da. The minor peak at 8887 is a matrix-associated artifact of the MALDI-TOF.
Background: CCL2/JE/MCP-1

CCL2, also called monocyte chemotactic protein‑1 (MCP‑1) or JE, is a member of the C‑C or beta  chemokine family that is best known as a chemotactic agent for mononuclear cells (1, 2). Human CCL2 cDNA encodes a 99 amino acid (aa) precursor protein with a 23 aa signal peptide and a 76 aa mature protein (2). Removal of the first 5 aa of the mature protein, including the N-terminal pyrrolidone carboxylic acid‑modified glutamine, occurs naturally by metalloproteinase cleavage and down‑regulates activity but not receptor binding (3). CCL2 may form multiple bands from 8.7‑13.5 kDa on SDS‑PAGE due to non‑covalent dimerization and variable carbohydrate content (3). Mature human CCL2 shares 78‑79% aa identity with canine, porcine and equine CCL2, while mouse and rat express a form of CCL2 that is extended by 49 aa and shares only ~56% aa identity within the common region. Human CCL2 can, however, induce a response in murine cells (4). Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source (1, 2). In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2 (2). Additionally, it promotes Th2 polarization in CD4+ T cells (5). CCL2‑mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma (6, 7).

  • References:
    1. Yoshimura, T. et al. (1989) FEBS Lett. 244:487.
    2. Deshmane, S.L. et al. (2009) J. Interferon Cytokine Res. 29:313.
    3. Proost, P. et al. (1998) J. Immunol. 160:4034.
    4. Van Riper, G. et al. (1993) J. Exp. Med. 177:851.
    5. Luther, S.A. and J.G. Cyster (2001) Nat. Immunol. 2:102.
    6. Daly, C. et al. (2003) Microcirculation 10:247.
    7. Aukrust, P. et al. (2008) Arterioscler. Thromb. Vasc. Biol. 28:1909.
    • Entrez Gene IDs:
      6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
    • Alternate Names:
      C-C motif chemokine ligand 2; CCL2; GDCF-2; HC11; HSMCR30; MCAF; Mcp1; MCP-1; SCYA2; SMC-CF
    Related Research Areas
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    56 Citations: Showing 1 - 10
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    Species
    Applications
    Sample Type
    1. Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-Cadherin
      Authors: BL Hoh, K Rojas, L Lin, HZ Fazal, S Hourani, KW Nowicki, MB Schneider, K Hosaka
      J Am Heart Assoc, 2018;7(8):.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    2. Sulforaphane rescues amyloid-? peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
      Authors: KA Jhang, JS Park, HS Kim, YH Chong
      J Neuroinflammation, 2018;15(1):75.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    3. Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity
      Authors: D Sagar, NP Singh, R Ginwala, X Huang, R Philip, M Nagarkatti, P Nagarkatti, K Neumann, J Ruland, AM Andrews, SH Ramirez, ZK Khan, P Jain
      Sci Rep, 2017;7(1):2707.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    4. Aberrant SYK kinase signaling is essential for tumorigenesis induced by TSC2 inactivation
      Authors: Y Cui, WK Steagall, A Lamattina, G Pacheco-Ro, M Stylianou, P Kidambi, B Stump, F Golzarri, IO Rosas, C Priolo, EP Henske, J Moss, S El-Chemaly
      Cancer Res, 2017;0(0):.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    5. Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity
      Authors: T Ito, M Ishigami, Y Matsushita, M Hirata, K Matsubara, T Ishikawa, H Hibi, M Ueda, Y Hirooka, H Goto, A Yamamoto
      Sci Rep, 2017;7(0):44043.
      Species: Rat
      Sample Type: In Vivo
      Application: In Vivo
    6. miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
      Authors: A Bott, N Erdem, S Lerrer, A Hotz-Wagen, C Breunig, K Abnaof, A Wörner, H Wilhelm, E Münsterman, A Ben-Baruch, S Wiemann
      Oncotarget, 2017;8(27):43897-43914.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    7. Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury
      Authors: RI Menzies, JWR Booth, JJ Mullins, MA Bailey, FWK Tam, JT Norman, RJ Unwin
      EBioMedicine, 2017;0(0):.
      Species: Human
      Sample Type: Cell Culture Supernates
      Application: ELISA Standard
    8. p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1-induced vascular smooth muscle cell migration and proliferation
      Authors: NK Singh, J Janjanam, GN Rao
      J. Biol. Chem., 2017;0(0):.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    9. Matrix degradability controls multicellularity of 3D cell migration
      Authors: B Trappmann, BM Baker, WJ Polacheck, CK Choi, JA Burdick, CS Chen
      Nat Commun, 2017;8(1):371.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    10. Decellularization and Solubilization of Porcine Liver for Use as a Substrate for Porcine Hepatocyte Culture: Method Optimization and Comparison
      Authors: RE Coronado, M Somaraki-C, S Natesan, RJ Christy, JL Ong, GA Halff
      Cell Transplant, 2017;26(12):1840-1854.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    11. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
      Cell Death Dis, 2016;7(12):e2565.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    12. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo
      Authors: Woo Jin Lee
      Int J Mol Sci, 2016;17(6):.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    13. Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
      Authors: RG de Bruin, L Shiue, J Prins, HC de Boer, A Singh, WS Fagg, JM van Gils, JM Duijs, S Katzman, AO Kraaijevel, S Böhringer, WY Leung, SM Kielbasa, JP Donahue, PH van der Za, R Sijbom, CM van Alem, I Bot, C van Kooten, JW Jukema, H Van Esch, T Rabelink
      Nat Commun, 2016;7(0):10846.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    14. PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
      J Neuroinflammation, 2016;13(1):254.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    15. Cytokine-Like 1 Regulates Cardiac Fibrosis via Modulation of TGF-? Signaling
      PLoS ONE, 2016;11(11):e0166480.
      Species: Rat
      Sample Type: Whole Cells
      Application: Bioassay
    16. Adsorption as a Contributor for Inflammatory Mediators Removal by Different Hemofiltration Membranes: A Pilot Study
      Authors: Benjamin Malard
      Artif Organs, 2016;0(0):.
      Species: Human
      Sample Type: Plasma
      Application: Hemofiltration Procedure
    17. Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling
      Sci Rep, 2016;6(0):39190.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    18. S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo.
      Authors: Chen, Bo, Miller, Allison, Rebelatto, Marlon, Brewah, Yambasu, Rowe, Daniel C, Clarke, Lori, Czapiga, Meggan, Rosenthal, Kim, Imamichi, Tomozumi, Chen, Yan, Chang, Chew-Shu, Chowdhury, Partha S, Naiman, Brian, Wang, Yue, Yang, De, Humbles, Alison A, Herbst, Ronald, Sims, Gary P
      PLoS ONE, 2015;10(2):e0115828.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    19. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
      Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
      Invest Ophthalmol Vis Sci, 2015;56(2):1051-62.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    20. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
      Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
      J Immunol, 2015;194(8):3634-45.
      Species: Mouse
      Sample Type: Whole Cells
      Application: Bioassay
    21. Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival.
      Authors: Kayisli U, Basar M, Guzeloglu-Kayisli O, Semerci N, Atkinson H, Shapiro J, Summerfield T, Huang S, Prelle K, Schatz F, Lockwood C
      Proc Natl Acad Sci U S A, 2015;112(16):5153-8.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    22. Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation.
      Authors: Singh, Meera V, Davidson, Donna C, Jackson, Joseph W, Singh, Vir B, Silva, Jharon, Ramirez, Servio H, Maggirwar, Sanjay B
      J Immunol, 2014;192(10):4674-84.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    23. Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.
      Authors: Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J
      J Exp Med, 2014;211(10):1957-68.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    24. CD14(hi)HLA-DR(dim) macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease.
      Authors: Thiesen S, Janciauskiene S, Uronen-Hansson H, Agace W, Hogerkorp C, Spee P, Hakansson K, Grip O
      J Leukoc Biol, 2014;95(3):531-41.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    25. Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
      Authors: Nguyen Hoang A, Chen P, Bjornfot S, Hogstrand K, Lock J, Grandien A, Coles M, Svensson M
      J Leukoc Biol, 2014;96(3):481-9.
    26. Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro.
      Authors: Italiani, Paola, Mazza, Emilia M, Lucchesi, Davide, Cifola, Ingrid, Gemelli, Claudia, Grande, Alexis, Battaglia, Cristina, Bicciato, Silvio, Boraschi, Diana
      PLoS ONE, 2014;9(2):e87680.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    27. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8.
      Authors: Sukkurwala A, Martins I, Wang Y, Schlemmer F, Ruckenstuhl C, Durchschlag M, Michaud M, Senovilla L, Sistigu A, Ma Y, Vacchelli E, Sulpice E, Gidrol X, Zitvogel L, Madeo F, Galluzzi L, Kepp O, Kroemer G
      Cell Death Differ, 2014;21(1):59-68.
    28. Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.
      Authors: van Gils, Janine M, Ramkhelawon, Bhama, Fernandes, Luciana, Stewart, Merran C, Guo, Liang, Seibert, Tara, Menezes, Gustavo, Cara, Denise C, Chow, Camille, Kinane, T Bernar, Fisher, Edward A, Balcells, Mercedes, Alvarez-Leite, Jacqueli, Lacy-Hulbert, Adam, Moore, Kathryn
      Arterioscler Thromb Vasc Biol, 2013;33(5):911-9.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    29. Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall remodeling.
      Authors: Kundumani-Sridharan, Venkates, Singh, Nikhlesh, Kumar, Sanjay, Gadepalli, Ravisekh, Rao, Gadipart
      J Biol Chem, 2013;288(30):22150-62.
      Species: Human
      Sample Type: Whole Cells
      Application: cell culture
    30. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration.
      Authors: Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G
      J Biol Chem, 2013;288(43):30815-31.
    31. The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.
      Authors: Chen Z, Kim S, Chamberlain N, Pickens S, Volin M, Volkov S, Arami S, Christman J, Prabhakar B, Swedler W, Mehta A, Sweiss N, Shahrara S
      J Immunol, 2013;190(10):5256-66.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    32. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
      Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
      Nature, 2012;487(7408):505-9.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    33. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha.
      Authors: Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM
      J. Biol. Chem., 2011;286(2):961-75.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    34. A multiplex immunoassay for human adipokine profiling.
      Authors: Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E
      Clin. Chem., 2010;56(0):1320.
    35. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.
      Authors: Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M
      Immunology, 2010;129(4):536-46.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    36. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
      Authors: Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG
      J. Immunol., 2010;184(3):1642-52.
      Species: Human
      Sample Type: Carbohydrates
      Application: Bioassay
    37. IL-17 induces monocyte migration in rheumatoid arthritis.
      Authors: Shahrara S, Pickens SR, Dorfleutner A, Pope RM
      J. Immunol., 2009;182(6):3884-91.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    38. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
      Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
      J. Immunol., 2008;181(11):8053-67.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    39. C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.
      Authors: Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F
      J. Leukoc. Biol., 2008;84(4):1109-19.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    40. Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation.
      Authors: Bonecchi R, Borroni EM, Anselmo A, Doni A, Savino B, Mirolo M, Fabbri M, Jala VR, Haribabu B, Mantovani A, Locati M
      Blood, 2008;112(3):493-503.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    41. Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
      Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
      Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    42. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
      Authors: Pfleger C, Schloot N, ter Veld F
      J. Immunol. Methods, 2007;329(1):214-8.
      Species: N/A
      Sample Type: N/A
      Application: ELISA Standard
    43. Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines.
      Authors: Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA
      Clin. Chem., 2007;53(11):2010-2.
      Species: N/A
      Sample Type: N/A
      Application: ELISA Standard
    44. TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC.
      Authors: Siegbahn A, Johnell M, Nordin A, Aberg M, Velling T
      Arterioscler. Thromb. Vasc. Biol., 2007;28(1):135-41.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    45. Ultrasensitive flow-based immunoassays using single-molecule counting.
      Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
      Clin. Chem., 2007;53(11):1990-5.
      Species: N/A
      Sample Type: N/A
      Application: ELISA Standard
    46. Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells.
      Authors: Brown CE, Vishwanath RP, Aguilar B, Starr R, Najbauer J, Aboody KS, Jensen MC
      J. Immunol., 2007;179(5):3332-41.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    47. The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes.
      Authors: Burt D, Salvidio G, Tarabra E, Barutta F, Pinach S, Dentelli P, Camussi G, Perin PC, Gruden G
      Am. J. Pathol., 2007;171(6):1789-99.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    48. Novel antiviral activity of chemokines.
      Authors: Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O
      Virology, 2006;350(2):484-92.
      Species: Virus
      Sample Type: Virus
      Application: Binding Assay
    49. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
      Authors: Nguyen AN, Stebbins EG, Henson M, O&amp;amp;apos;Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS
      Exp. Cell Res., 2006;312(10):1909-23.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    50. CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands.
      Authors: Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D
      J. Immunol., 2006;176(10):5760-71.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    51. HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS.
      Authors: Eugenin EA, Dyer G, Calderon TM, Berman JW
      Glia, 2005;49(4):501-10.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    52. Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2.
      Authors: Traves SL, Smith SJ, Barnes PJ, Donnelly LE
      J. Leukoc. Biol., 2004;76(2):441-50.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    53. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
      Authors: Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
      J. Immunol., 2004;173(11):6592-602.
      Species: Human
      Sample Type: Whole Cells
      Application: Bioassay
    54. trans fatty acids and systemic inflammation in heart failure.
      Authors: Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
      Am. J. Clin. Nutr., 2004;80(6):1521-5.
      Species: N/A
      Sample Type: N/A
      Application: ELISA Standard
    55. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
      Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
      Blood, 2004;104(2):314-20.
      Species: N/A
      Sample Type: N/A
      Application: ELISA Standard
    56. Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain.
      Authors: Banisadr G, Queraud-Lesaux F, Boutterin MC, Pelaprat D, Zalc B, Rostene W, Haour F, Parsadaniantz SM
      J. Neurochem., 2002;81(2):257-69.
      Species: Rat
      Sample Type: Whole Tissue
      Application: Binding Study
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