Recombinant Human CD164 Fc Chimera Protein, CF Summary
|Human CD164 |
Accession # Q04900-1
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in MES and NaCl.|
|Reconstitution||Reconstitute at 500 μg/mL in water.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some researchers may wish to use polypeptides to make antibodies. To facilitate the advancement of new science, we now offer our Innovator Series of proteins.
CD164 is a mucin-like glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells. It is composed of a signal sequence, an extracellular domain, a transmembrane domain and an intracellular domain (1). The CD164 cDNA encodes a 178-amino acid polypeptide core, of which residues 140‑164 represent the predicted transmembrane domain and residues 165-178 form a short cytoplasmic domain (2). Biochemical and functional analyses of human hematopoietic cell lines and transfectants demonstrate that CD164 comprises a homodimeric molecule of approximately 160 kDa. It plays an important role in mediating or regulating hematopoietic precursor cell adhesion to stroma, and may serve as a potent negative regulator of hematopoietic progenitor cell proliferation (3). Moreover, recent studies have indicated that CD164 may be a basophil activation marker, potentially useful in diagnosis of allergy caused by variety of allergens, including drug allergen (4). The molecule is extensively glycosylated with sites of O-linked glycosylation clustered in two discrete mucin domains separated by a more globular cysteine-rich region (1).
- Zannettino, A.C. et al. (1998) Blood 92:2613.
- Watt, S.M. et al. (1998) Blood 92:849.
- Watt, S.M. and J.Y. Chan (2000) Leuk. Lyphoma. 37:1.
- Wolanczyk-Medrala, A. et al. (2011) Curr. Pharm. Des. 17:3786.
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