1 μg/lane of Recombinant Human CD2F/SLAMF9 Fc Chimera (Catalog # 8235-CD) wasresolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions andvisualized by silver staining, showing R bands at 60-70 kDa and NR bandsat 150-160 kDa.
The CD2 family of receptors is a subset of the immunoglobulin superfamily of glycoproteins. The CD2F-10 protein, also known as SF2001 and CD85-H1, was identified as a CD2 subfamily member using genome sequence data. Based on its structural organization, CD2F-10 belongs to the SLAM (Signaling Lymphocyte Activation Molecule) subfamily of CD2 receptors and is designated SLAMF9. SLAM proteins function as co-receptors for lymphocyte activation and/or adhesion (1). Mature human CD2F-10 is a type I transmembrane glycoprotein that consists of a 218 amino acid (aa) extracellular domain (ECD) with one Ig-like C2-set domain, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain (2-4). Unlike other SLAM proteins, the cytoplasmic domain of CD2F-10 does not contain consensus immunoreceptor tyrosine-based switch motifs (ITSMs) that mediate interactions with the signal transduction proteins SAP or EAT-2 (1). Within aa 19-210, human CD2F-10 shares 57% and 59% aa sequence identity with mouse and rat CD2F-10, respectively. Alternative splicing of human CD2F-10 generates an isoform that lacks the Ig-like C2-set domain. CD2F-10 is expressed in hematopoietic tissues and cell lines (3). R&D in house data indicate that CD2F-10 inhibits the secretion of IL-2 from activated human T cells.
Cannons, J.L. et al. (2011) Annu. Rev. Immunol. 29:665.
Fennelly, J.A. et al. (2001) Immunogenetics 53:599.
Zhang, W. et al. (2001) Clin. Cancer Res. 7:822s.
Fraser, C.C. et al. (2002) Immunogenetics 53:843.
CD2 Family 10/SLAM Family Member 9
Entrez Gene IDs:
89886 (Human); 98365 (Mouse)
CD2 family member 10; CD2F10; CD2F-10; CD2F-10MGC88194; CD84 homolog 1; CD84H1; CD84-H1; CD84-H1cluster of differentiation 2 antigen family member 10; cluster of differentiation 84 homolog 1; SF2001; signaling lymphocytic activation molecule family member 2001; signaling lymphocytic activation molecule family member 9; SLAM family member 9; SLAMF9
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