Recombinant Human IFN-alpha 2 (alpha 2b) Protein

Newer Version Available: 11013-IF
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R&D Systems Recombinant Proteins and Enzymes
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Citations (7)

Recombinant Human IFN-alpha 2 (alpha 2b) Protein Summary

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Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Background: IFN-alpha 2/IFNA2

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name
Interferon alpha 2
Entrez Gene IDs
3440 (Human); 15965 (Mouse); 298213 (Rat)
Alternate Names
alpha-2a interferon; Ifa2; IFNA; IFNA2; IFNA2a; IFNA2b; IFNA2c; IFNAA; IFNalpha 2; IFN-alpha 2; IFN-alpha-2; IFN-alphaA; INFA2; interferon alpha 2b; interferon alpha A; interferon alpha-2; Interferon alpha-A; interferon, alpha 2; LeIF A; MGC125764; MGC125765

Citations for Recombinant Human IFN-alpha 2 (alpha 2b) Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells
    Authors: I Pietrafort, A Butera, L Gaddini, A Mennella, R Palazzo, D Campanile, K Stefananto, V Riccieri, R Lande, L Frasca
    International Journal of Molecular Sciences, 2022-12-30;24(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. Improved yield of recombinant human IFN-alpha2b from mammalian cells using heterologous signal peptide approach
    Authors: C Wilkinson, J Kyle, M Irimpen, S Stuart, S Mohandass, A Sheperd, KJ Smith, MJ Mullin
    Protein Expression and Purification, 2022-06-02;198(0):106125.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit�Hantaan orthohantavirus replication
    Authors: AM Kell, EA Hemann, JB Turnbull, M Gale
    PLoS Pathog., 2020-04-24;16(4):e1008483.
    Species: Human
    Sample Types: HUVEC
    Applications: Cell Culture
  4. A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis
    Authors: C He, X Lv, C Huang, PC Angeletti, G Hua, J Dong, J Zhou, Z Wang, B Ma, X Chen, PF Lambert, BR Rueda, JS Davis, C Wang
    Cell Rep, 2019-03-05;26(10):2636-2650.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Role of microRNA modulation in the interferon-alpha/ribavirin suppression of HIV-1 in vivo.
    Authors: Abdel-Mohsen M, Deng X, Danesh A, Liegler T, Jacobs E, Rauch A, Ledergerber B, Norris P, Gunthard H, Wong J, Pillai S
    PLoS ONE, 2014-10-02;9(10):e109220.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
    Authors: Lee PY, Li Y, Richards HB, Chan FS, Zhuang H, Narain S, Butfiloski EJ, Sobel ES, Reeves WH, Segal MS
    Arthritis Rheum., 2007-11-01;56(11):3759-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay


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