<1.0 EU per 1 μg of the protein by the LAL method.
Interferon was titrated with the use of the cytopathic effect inhibition assay as
described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons,"
J. Virol. 37, 755-758;
Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for
Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral
assay for interferon about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. As there
is no international standard for human interferon omega, the units are determined with respect to the international
reference standard for human interferon alpha A (Hu-IFN-
alpha A) provided by the National Institutes of Health [see Pestka, S.
(1986) "Interferon Standards and General Abbreviations," in
Methods in Enzymology (S. Pestka, ed.), Academic Press,
New York 119, 14-23]. Unit of activity measured on human lung carcinoma cell line A549 with encephalomyocarditis virus
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Interferon-omega (IFN-omega), a type I interferon, is a monomeric glycoprotein distantly related in structure to IFN-alpha and IFN-beta, but unrelated to IFN-gamma. The human type I interferon receptor complex, which mediates the biological activity of IFN-alpha and IFN-beta, also binds IFN-omega. The complex is composed of a 100 kDa ligand-binding subunit (IFN-alpha R1) and a 125 kDa subunit (IFN-alpha R2) that is involved both in ligand binding and signal transduction. IFN-omega is secreted by virus-infected leukocytes.
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but also provides information about sample types, species, and experimental conditions.
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