Recombinant Human IFN-omega Protein

Catalog # Availability Size / Price Qty
11395-1
Product Details
Citations (1)
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Recombinant Human IFN-omega Protein Summary

Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. As there is no international standard for human interferon omega, the units are determined with respect to the international reference standard for human interferon alpha A (Hu-IFN- alpha A) provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23]. Unit of activity measured on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV).
Source
E. coli-derived human IFN-omega protein
Accession #
Predicted Molecular Mass
20 kDa

Product Datasheets

11395-1

Formulation Phosphate buffered saline (PBS) containing 2% bovine serum albumin (BSA)
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Background: IFN-omega

Interferon-omega (IFN-omega), a type I interferon, is a monomeric glycoprotein distantly related in structure to IFN-alpha and IFN-beta, but unrelated to IFN-gamma. The human type I interferon receptor complex, which mediates the biological activity of IFN-alpha and IFN-beta, also binds IFN-omega. The complex is composed of a 100 kDa ligand-binding subunit (IFN-alpha R1) and a 125 kDa subunit (IFN-alpha R2) that is involved both in ligand binding and signal transduction. IFN-omega is secreted by virus-infected leukocytes.

Long Name
Interferon omega
Entrez Gene IDs
3467 (Human)
Alternate Names
IFN-omega 1, interferon omega-1; IFNomega; IFN-omega; IFNW1; Interferon alpha-II-1; interferon omega-1; interferon, omega 1

Citation for Recombinant Human IFN-omega Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APC.
    Authors: Qu C, Moran TM, Randolph GJ
    J. Immunol., 2003;170(2):1010-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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