Recombinant Human IFN-omega Protein

  (1 citations)     
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Citations (1)
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  • Endotoxin Level
    <1.0 EU per 1 μg of the protein by the LAL method.
  • Activity
    Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. As there is no international standard for human interferon omega, the units are determined with respect to the international reference standard for human interferon alpha A (Hu-IFN- alpha A) provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23]. Unit of activity measured on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV).
  • Source
    E. coli-derived human IFN-omega protein
  • Accession #
  • Predicted Molecular Mass
    20 kDa
Product Datasheets

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11395-1
 
Formulation Phosphate buffered saline (PBS) containing 2% bovine serum albumin (BSA)
 
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
 
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
 
Background: IFN-omega
Interferon-omega (IFN-omega), a type I interferon, is a monomeric glycoprotein distantly related in structure to IFN-alpha and IFN-beta, but unrelated to IFN-gamma. The human type I interferon receptor complex, which mediates the biological activity of IFN-alpha and IFN-beta, also binds IFN-omega. The complex is composed of a 100 kDa ligand-binding subunit (IFN-alpha R1) and a 125 kDa subunit (IFN-alpha R2) that is involved both in ligand binding and signal transduction. IFN-omega is secreted by virus-infected leukocytes.
  • Long Name:
    Interferon omega
  • Entrez Gene IDs:
    3467 (Human)
  • Alternate Names:
    IFN-omega 1, interferon omega-1; IFNomega; IFN-omega; IFNW1; Interferon alpha-II-1; interferon omega-1; interferon, omega 1
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citations: Showing 1 - 1

  1. Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APC.
    Authors: Qu C, Moran TM, Randolph GJ
    J. Immunol., 2003;170(2):1010-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay

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