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Recombinant Human IL-3 Protein

203-IL 146 Citations 3 Reviews Datasheet / COA / SDS
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Formulations:
Catalog # Availability Size / Price Qty
203-IL-010
203-IL-050
203-IL-100
203-IL-250
203-IL-500
203-IL-01M
Recombinant Human IL-3 Protein Data
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Product Details
Citations (146)
FAQs
Supplemental Products
Reviews (3)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IL-3 Protein Summary

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.02-0.1 ng/mL.
The specific activity of Recombinant Human IL-3 is approximately 1.8 x 103 IU/μg, which is calibrated against recombinant human IL-3 WHO International Standard (NIBSC code: 91/510).
Source
E. coli-derived human IL-3 protein
Ala20-Phe152, with and without an N-terminal Met
Accession #
AAC08706
N-terminal Sequence
Analysis
Ala20 and Met
Predicted Molecular Mass
15 kDa

Product Datasheets

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

203-IL

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

203-IL/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity View Larger

Recombinant Human IL-3 (Catalog # 203-IL) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50for this effect is 0.02-0.1 ng/mL.

SDS-PAGE View Larger

1 μg/lane of Recombinant Human IL-3 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-3

Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor, P-cell stimulating factor, burst promoting activity, multi-colony stimulating factor, thy-1 inducing factor and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes can also produce IL-3. At the amino acid sequence level, mature human and murine IL-3 share only 29% sequence identity. Consistent with this lack of homology, IL-3 activity is highly species-specific and human IL-3 does not show activity on murine cells.

IL-3 exerts its biological activities through binding to specific cell surface receptors. The high affinity receptor responsible for IL-3 signaling is composed of at least two subunits, an IL-3 specific alpha chain which binds IL-3 with low affinity and a common beta chain that is shared by the IL-5 and GM-CSF high-affinity receptors. Although the beta chain itself does not bind IL-3, it confers high-affinity IL-3 binding in the presence of the  alpha chain. Receptors for IL-3 are present on bone marrow progenitors, macrophages, mast cells, eosinophils, megakaryocytes, basophils and various myeloid leukemic cells.

Long Name
Interleukin 3
Entrez Gene IDs
3562 (Human); 16187 (Mouse); 24495 (Rat)
Alternate Names
Hematopoietic growth factor; IL3; IL-3; IL-3MGC79398; interleukin 3 (colony-stimulating factor, multiple); interleukin-3; Mast cell growth factor; mast-cell growth factor; MCGF; MCGFMGC79399; MULTI-CSF; multilineage-colony-stimulating factor; Multipotential colony-stimulating factor; P-cell stimulating factor; P-cell-stimulating factor

Citations for Recombinant Human IL-3 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

146 Citations: Showing 1 - 10
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  1. Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells
    Authors: J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou
    Cell Rep, 2020;31(9):107688.
    Species: Human
    Sample Types:
    Applications: Cell Culture
  2. Expression and Retention of Thymidine Phosphorylase in Cultured Reticulocytes as a Novel Treatment for MNGIE
    Authors: M Meinders, D Shoemark, JGG Dobbe, GJ Streekstra, J Frayne, AM Toye
    Mol Ther Methods Clin Dev, 2020;17(0):822-830.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes
    Authors: MAE Rab, BA van Oirsch, PA Kosinski, J Hixon, K Johnson, V Chubukov, L Dang, G Pasterkamp, S van Straat, WW van Soling, EJ van Beers, C Kung, R van Wijk
    Haematologica, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans
    Authors: SL Taylor, J Hogwood, W Guo, EA Yates, JE Turnbull
    Sci Rep, 2019;9(1):2679.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I
    Authors: M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue
    Stem Cell Res, 2019;36(0):101406.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
    Authors: H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids
    Authors: AK Seneviratn, M Xu, JJA Henao, VA Fajardo, Z Hao, V Voisin, GW Xu, R Hurren, S Kim, N MacLean, X Wang, M Gronda, D Jeyaraju, Y Jitkova, T Ketela, M Mullokando, D Sharon, G Thomas, R Chouinard-, JR Hawley, C Schafer, HL Yau, Z Khuchua, A Aman, R Al-Awar, A Gross, SM Claypool, R Bazinet, M Lupien, S Chan, DD De Carvalh, MD Minden, GD Bader, KD Stark, P LeBlanc, AD Schimmer
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling
    Authors: P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris
    Stem Cell Res, 2019;34(0):101344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Vimentin expression is retained in erythroid cells differentiated from human iPSC and ESC and indicates dysregulation in these cells early in differentiation
    Authors: K Trakarnsan, D Ferguson, DE Daniels, RE Griffiths, MC Wilson, KE Mordue, A Gartner, TN Andrienko, A Calvert, A Condie, A McCahill, JC Mountford, AM Toye, DJ Anstee, J Frayne
    Stem Cell Res Ther, 2019;10(1):130.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
    Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
    Cell Rep, 2019;27(2):599-615.e12.
    Species: Human
    Sample Types: cell culture
    Applications: Differentiation
  11. Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells
    Authors: M Ruiz-Gutie, ÖV Bölükba??, G Alexe, AG Kotini, K Ballotti, CE Joyce, DW Russell, K Stegmaier, K Myers, CD Novina, EP Papapetrou, A Shimamura
    JCI Insight, 2019;5(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients
    Authors: M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa
    Haematologica, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Human Blood and Tonsil Plasmacytoid Dendritic Cells Display Similar Gene Expression Profiles but Exhibit Differential Type I IFN Responses to Influenza A Virus Infection
    Authors: S Vangeti, J Gertow, M Yu, S Liu, F Baharom, S Scholz, D Friberg, M Starkhamma, A Ahlberg, A Smed-Sören
    J. Immunol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance
    Authors: M Ly, S Rentas, A Vujovic, N Wong, S Moreira, J Xu, N Holzapfel, S Bhatia, D Tran, MD Minden, JS Draper, KJ Hope
    Cancer Res., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
    Authors: MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins
    Cell Stem Cell, 2019;25(2):258-272.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
    Authors: WR Proto, SV Siegel, S Dankwa, W Liu, A Kemp, S Marsden, ZA Zenonos, S Unwin, PM Sharp, GJ Wright, BH Hahn, MT Duraisingh, JC Rayner
    Nat Commun, 2019;10(1):4512.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
    Authors: J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen
    Nat Commun, 2019;10(1):4856.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders
    Authors: N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, AE Krouse, ME Metzger, RE Donahue, JF Tisdale
    Nat Commun, 2019;10(1):4479.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  19. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
    Authors: VA Balaji Rag, M Anwar, MZ Akhter, A Chavez, Y Mao, V Natarajan, S Lakshmikan, M Chrzanowsk, AZ Dudek, L Claesson-W, JK Kitajewski, KK Wary, AB Malik, D Mehta
    Cell Rep, 2019;29(11):3472-3487.e4.
    Species: Human
    Sample Types: Whole Cells
  20. Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population
    Authors: R Leylek, M Alcántara-, Z Lanzar, A Lüdtke, OA Perez, B Reizis, J Idoyaga
    Cell Rep, 2019;29(11):3736-3750.e8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models
    Authors: AT Stefka, D Johnson, S Rosebeck, JH Park, Y Nakamura, AJ Jakubowiak
    Cancer Med, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system
    Authors: JP Ruiz, G Chen, JJ Haro Mora, K Keyvanfar, C Liu, J Zou, J Beers, H Bloomer, H Qanash, N Uchida, JF Tisdale, M Boehm, A Larochelle
    Stem Cell Res, 2019;41(0):101600.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
    Authors: M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley
    Cell Stem Cell, 2018;22(4):575-588.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment
    Authors: S Kotha, S Sun, A Adams, B Hayes, KT Phong, R Nagao, JA Reems, D Gao, B Torok-Stor, JA López, Y Zheng
    PLoS ONE, 2018;13(4):e0195082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin
    Authors: KT Barretto, CM Swanson, CL Nguyen, DS Annis, SJ Esnault, DF Mosher, MW Johansson
    PLoS ONE, 2018;13(7):e0201320.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Generation and characterization of two human induced pluripotent stem cell (hiPSC) lines homozygous for the Apolipoprotein e4 (APOE4) risk variant-Alzheimer's disease (ASUi005-A) and healthy non-demented control (ASUi006-A)
    Authors: N Brookhouse, P Zhang, R Caselli, JJ Kim, DA Brafman
    Stem Cell Res, 2018;32(0):145-149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Transfection of Peripheral Blood Monocytes with SOX2 Enhances Multipotency, Proliferation, and Redifferentiation into Neohepatocytes and Insulin-Producing Cells
    Authors: A Hyder, S Ehnert, F Fändrich, H Ungefroren
    Stem Cells Int, 2018;2018(0):4271875.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation
    Authors: Y Heshmati, S Kharazi, G Türköz, D Chang, E Kamali Dol, J Boström, A Krstic, T Boukoura, E Wagner, N Kadri, R Månsson, M Altun, H Qian, J Walfridsso
    Sci Rep, 2018;8(1):11202.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin.
    Authors: Karina T Barretto, Calvin M Swanson, Christopher L Nguyen, Douglas S Annis, Stephane J Esnault, Deane F Mosher, Mats W Johansson
    PLoS ONE, 2018;0(0):1932-6203.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Optimization of an erythroid culture system to reduce the cost of in vitro production of red blood cells
    Authors: S Poldee, C Metheetrai, S Nugoolsuks, J Frayne, K Trakarnsan
    MethodsX, 2018;5(0):1626-1632.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments
    Authors: S Radecke, K Schwarz, F Radecke
    Mol. Ther., 2018;26(1):115-131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. STK3 is a therapeutic target for a subset of acute myeloid leukemias
    Authors: A Camgoz, M Paszkowski, S Satpathy, M Wermke, MV Hamann, M von Bonin, C Choudhary, S Knapp, F Buchholz
    Oncotarget, 2018;9(39):25458-25473.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
    Authors: K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina
    Virology, 2018;515(0):235-242.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
    Authors: CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs
    Genes Dev., 2018;32(5):373-388.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. PTEN is indispensable for cells to respond to MAPK inhibitors in myeloid leukemia
    Authors: J Zhang, Z Xiang, PA Malaviarac, Y Yan, NJ Baltz, PD Emanuel, YL Liu
    Cell. Signal., 2018;50(0):72-79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach
    Authors: R Berndt, L Hummitzsch, K He beta, M Albrecht, K Zitta, R Rusch, B Sarras, A Bayer, J Cremer, F Faendrich, J Gro beta
    Stem Cell Res Ther, 2018;9(1):117.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
    Authors: JM Orengo, AR Radin, V Kamat, A Badithe, LH Ben, BL Bennett, S Zhong, D Birchard, A Limnander, A Rafique, J Bautista, A Kostic, D Newell, X Duan, MC Franklin, W Olson, T Huang, NA Gandhi, L Lipsich, N Stahl, NJ Papadopoul, AJ Murphy, GD Yancopoulo
    Nat Commun, 2018;9(1):1421.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
    Authors: K Trakarnsan, RE Griffiths, MC Wilson, A Blair, TJ Satchwell, M Meinders, N Cogan, S Kupzig, R Kurita, Y Nakamura, AM Toye, DJ Anstee, J Frayne
    Nat Commun, 2017;8(0):14750.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis
    Authors: L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk
    Sci Rep, 2017;7(1):6684.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9
    Authors: JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski
    J. Immunol, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC Induced Thrombocytopenia
    Authors: H Zhao, S Gulesseria, SK Ganesan, J Ou, K Morrison, Z Zeng, V Robles, J Snyder, L Do, H Aviña, S Karki, DR Stover, F Doñate
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption
    Authors: CY Chiu, SC Su, WL Fan, SH Lai, MH Tsai, SH Chen, KS Wong, WH Chung
    Sci Rep, 2017;7(0):43469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes
    Authors: A Palau, AK Garz, J Diesch, A Zwick, R Malinverni, V Valero, K Lappin, R Casquero, A Lennartsso, J Zuber, T Navarro, KI Mills, KS Götze, M Buschbeck
    Oncotarget, 2017;8(70):115002-115017.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML
    Authors: SU Liyanage, R Hurren, V Voisin, G Bridon, X Wang, C Xu, N MacLean, TP Siriwarden, M Gronda, D Yehudai, S Sriskantha, D Avizonis, A Shamas-Din, MD Minden, GD Bader, R Laposa, AD Schimmer
    Blood, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Mechanistic Correlates of Clinical Responses to Omalizumab in the Setting of Oral Immunotherapy for Milk Allergy
    Authors: PA Frischmeye, M Masilamani, W Gu, E Brittain, R Wood, J Kim, K Nadeau, KM Jarvinen, A Grishin, R Lindblad, HA Sampson
    J. Allergy Clin. Immunol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Blood
    Applications: Bioassay
  46. Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain
    Authors: RHP Wilbers, DR van Raaij, LB Westerhof, J Bakker, G Smant, A Schots
    PLoS ONE, 2017;12(10):e0186317.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
    Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
    Cell Rep, 2017;20(7):1597-1608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia
    Authors: AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
    Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
    Stem Cell Res, 2017;21(0):19-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
    Authors: N Rahman, PM Brauer, L Ho, T Usenko, M Tewary, JC Zúñiga-Pfl, PW Zandstra
    Nat Commun, 2017;8(0):15380.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement
    Authors: E Schuh, A Musumeci, FS Thaler, S Laurent, JW Ellwart, R Hohlfeld, A Krug, E Meinl
    J. Immunol, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency
    Authors: JH Lee, S Laronde, TJ Collins, Z Shapovalov, B Tanasijevi, JD McNicol, A Fiebig-Com, YD Benoit, JB Lee, RR Mitchell, M Bhatia
    Cell Rep, 2017;19(1):20-35.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
    Authors: DC Thomas, S Clare, JM Sowerby, M Pardo, JK Juss, DA Goulding, L van der We, D Storistean, A Prakash, M Espéli, S Flint, JC Lee, K Hoenderdos, L Kane, K Harcourt, S Mukhopadhy, Y Umrania, R Antrobus, JA Nathan, DJ Adams, A Bateman, JS Choudhary, PA Lyons, AM Condliffe, ER Chilvers, G Dougan, KG Smith
    J. Exp. Med, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells
    Authors: M Carretta, AZ Brouwers-V, M Bosman, SJ Horton, JHA Martens, E Vellenga, JJ Schuringa
    PLoS ONE, 2017;12(12):e0189102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
    Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
    Mol Ther Methods Clin Dev, 2017;5(0):241-258.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise
    Authors: H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes
    Immunology, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML
    Mol Ther Methods Clin Dev, 2016;3(0):16074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.
    Authors: Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
    Scientific Reports, 2016;0(0):2045-2322.
    Species: Xenograft
    Sample Types: In Vivo
    Applications: In Vivo
  60. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
    Authors: Ivan Carcamo-Or
    Cell Stem Cell, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors
    Sci Rep, 2016;6(0):32149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells
    PLoS ONE, 2016;11(11):e0165949.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts
    Blood, 2016;127(23):2879-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway
    Cell Biosci, 2016;6(1):50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia
    Oncogene, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta
    Authors: Amber N Stratman
    Development, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. A New Glucocerebrosidase Chaperone Reduces ?-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
    J Neurosci, 2016;36(28):7441-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Increased IFN-alpha-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-alpha production.
    Authors: Xia C, Peng R, Chernatynskaya A, Yuan L, Carter C, Valentine J, Sobel E, Atkinson M, Clare-Salzler M
    J Immunol, 2015;193(3):1024-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Preserved in vivo reconstitution ability of PBSCs cryopreserved for a decade at -80 degrees C.
    Authors: Shima T, Iwasaki H, Yamauchi T, Kadowaki M, Kiyosuke M, Mochimaru T, Takenaka K, Miyamoto T, Akashi K, Teshima T
    Bone Marrow Transplant, 2015;50(9):1195-200.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.
    Authors: Baharom F, Thomas S, Bieder A, Hellmer M, Volz J, Sandgren K, McInerney G, Karlsson Hedestam G, Mellman I, Smed-Sorensen A
    J Immunol, 2015;194(9):4422-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Prospectively Isolated Human Bone Marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells.
    Authors: Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, Uemura Y, Asano H, Sasaki Y, Inoue M, Ogawa H, Takahashi T, Hino M, Sonoda Y
    Stem Cells, 2015;33(5):1554-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Physiologic concentrations of HMGB1 have no impact on cytokine-mediated eosinophil survival or chemotaxis in response to Eotaxin-2 (CCL24).
    Authors: Dyer, Kimberly, Rosenberg, Helene F
    PLoS ONE, 2015;10(3):e0118887.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy.
    Authors: Baldwin K, Urbinati F, Romero Z, Campo-Fernandez B, Kaufman M, Cooper A, Masiuk K, Hollis R, Kohn D
    Stem Cells, 2015;33(5):1532-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Suppression of basophil FcvarepsilonRI activation by serum from active chronic idiopathic/spontaneous urticaria (CIU/CSU) subjects.
    Authors: Sterba P, Hamilton R, Saini S
    J Invest Dermatol, 2015;135(5):1454-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).
    Authors: Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q
    PLoS ONE, 2015;10(4):e0122983.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta.
    Authors: Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed K, Ehnert S, Nussler A, Fandrich F, Gieseler F
    PLoS ONE, 2015;10(2):e0118097.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  77. Transcriptome analysis of Kaposi's sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells.
    Authors: Purushothaman P, Thakker S, Verma S
    J Virol, 2015;89(6):3093-111.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia.
    Authors: Park I, Mundy-Bosse B, Whitman S, Zhang X, Warner S, Bearss D, Blum W, Marcucci G, Caligiuri M
    Leukemia, 2015;29(12):2382-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015;10(3):e0122149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Targeted 25-hydroxyvitamin D3 1alpha-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice.
    Authors: Li B, Baylink D, Walter M, Lau K, Meng X, Wang J, Cherkas A, Tang X, Qin X
    Mol Ther, 2015;23(2):339-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
    Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
    Stem Cells, 2015;33(4):1142-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
    Authors: Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J
    Blood, 2014;123(8):1239-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
    Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
    J Invest Dermatol, 2014;134(5):1246-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins.
    Authors: Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, Knight S, Nathwani A, Roberts D, Watt S, Carpenter L
    Br J Haematol, 2014;166(3):435-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells.
    Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
    J Leukoc Biol, 2014;95(6):893-901.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.
    Authors: Drewes J, Szeto G, Engle E, Liao Z, Shearer G, Zink M, Graham D
    PLoS ONE, 2014;9(4):e94375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Neutralizing antibodies inhibit HIV-1 infection of plasmacytoid dendritic cells by an FcgammaRIIa independent mechanism and do not diminish cytokines production.
    Authors: Lederle A, Su B, Holl V, Penichon J, Schmidt S, Decoville T, Laumond G, Moog C
    Sci Rep, 2014;4(0):5845.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. CD133 is a positive marker for a distinct class of primitive human cord blood-derived CD34-negative hematopoietic stem cells.
    Authors: Takahashi, M, Matsuoka, Y, Sumide, K, Nakatsuka, R, Fujioka, T, Kohno, H, Sasaki, Y, Matsui, K, Asano, H, Kaneko, K, Sonoda, Y
    Leukemia, 2014;28(6):1308-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
    Authors: van Wilgenburg, Bonnie, Moore, Michael, James, William, Cowley, Sally A
    PLoS ONE, 2014;9(1):e86071.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. NADPH oxidase-independent formation of extracellular DNA traps by basophils.
    Authors: Morshed M, Hlushchuk R, Simon D, Walls A, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon H, Yousefi S
    J Immunol, 2014;192(11):5314-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. CCK8 negatively regulates the TLR9-induced activation of human peripheral blood pDCs by targeting TRAF6 signaling.
    Authors: Jia X, Cong B, Zhang J, Li H, Liu W, Chang H, Dong M, Ma C
    Eur J Immunol, 2014;44(2):489-99.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
    Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
    Haematologica, 2014;99(1):19-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Epigenetic reprogramming induces the expansion of cord blood stem cells.
    Authors: Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R
    J Clin Invest, 2014;124(6):2378-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Gene transfer properties and structural modeling of human stem cell-derived AAV.
    Authors: Smith, Laura J, Ul-Hasan, Taihra, Carvaines, Sarah K, Van Vliet, Kim, Yang, Ethel, Wong, Kamehame, Agbandje-McKenna, Mavis, Chatterjee, Saswati
    Mol Ther, 2014;22(9):1625-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.
    Authors: Lin A, Burrascano C, Pettersson P, Ibanez C, Gruber H, Jolly D
    J Virol, 2014;88(17):10066-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.
    Authors: Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C
    Blood, 2014;123(20):3116-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Stress hematopoiesis is regulated by the Kruppel-like transcription factor ZBP-89.
    Authors: Li X, Romain R, Park D, Scadden D, Merchant J, Arnaout M
    Stem Cells, 2014;32(3):791-801.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.
    Authors: Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn, Jhas, Bozhena, Schimmer, Aaron D
    PLoS ONE, 2014;9(5):e95281.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.
    Authors: Liu, Suiyang, Yin, Li, Stroopinsky, Dina, Rajabi, Hasan, Puissant, Alexandr, Stegmaier, Kimberly, Avigan, David, Kharbanda, Surender, Kufe, Donald, Stone, Richard
    Blood, 2014;123(5):734-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.
    Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
    Stem Cells, 2014;32(5):1337-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells.
    Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
    Mol Ther, 2013;21(5):1044-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
    Authors: Yu, Jianhua, Peng, Yong, Wu, Lai-Chu, Xie, Zhiliang, Deng, Youcai, Hughes, Tiffany, He, Shun, Mo, XiaoKui, Chiu, Ming, Wang, Qi-En, He, Xiaoming, Liu, Shujun, Grever, Michael, Chan, Kenneth, Liu, Zhongfa
    PLoS ONE, 2013;8(2):e55934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
    Authors: Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S
    J Immunol, 2013;190(8):3959-66.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  104. Endogenous erythroid colony formation in chronic myeloid leukemia: a recurrent finding associated with persistent minimal residual disease under imatinib.
    Authors: Einwallner E, Jaeger E, Mitterbauer-Hohendanner G, Bilban M, Simonitsch-Klupp I, Steiner I, Pernicka E, Hoermann G, Herndlhofer S, Sillaber C, Valent P, Schwarzinger I
    Stem Cells Dev, 2013;22(23):3043-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
    Authors: Smith A, Bowers S, Stratman A, Davis G
    PLoS ONE, 2013;8(12):e85147.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
    Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
    Cell Stem Cell, 2013;13(4):459-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells.
    Authors: Thanunchai, Maytawan, Kanrai, Pumaree, Wiboon-Ut, Suwimon, Puthavathana, Pilaipan, Hongeng, Suradej, Thitithanyanont, Arunee
    PLoS ONE, 2013;8(12):e81805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. MHC class II expression in human basophils: induction and lack of functional significance.
    Authors: Voskamp A, Prickett S, Mackay F, Rolland J, O'Hehir R
    PLoS ONE, 2013;8(12):e81777.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  109. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012;12(0):431.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Neurotensin and CRH interactions augment human mast cell activation.
    Authors: Alysandratos K, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, Critchfield A, Theoharides T
    PLoS ONE, 2012;7(11):e48934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interaction.
    Authors: Donhauser N, Pritschet K, Helm M, Harrer T, Schuster P, Ries M, Bischof G, Vollmer J, Smola S, Schmidt B
    PLoS ONE, 2012;7(3):e33925.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
    Authors: Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y
    J Biol Chem, 2012;287(34):29088-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms.
    Blood Cancer J, 2012;2(0):e87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations.
    Authors: Bond E, Liang F, Sandgren KJ, Smed-Sorensen A, Bergman P, Brighenti S, Adams WC, Betemariam SA, Rangaka MX, Lange C, Wilkinson RJ, Andersson J, Lore K
    J. Invest. Dermatol., 2011;132(1):114-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor.
    Authors: Torrano V, Procter J, Cardus P
    Blood, 2011;118(18):4910-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.
    Authors: Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A
    Oncogene, 2011;30(23):2622-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Optimal conditions for lentiviral transduction of engrafting human CD34+ cells.
    Authors: Uchida N, Hsieh MM, Hayakawa J, Madison C, Washington KN, Tisdale JF
    Gene Ther., 2011;18(11):1078-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
    Authors: Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B
    Blood, 2011;117(3):839-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.
    Authors: Niwa A, Heike T, Umeda K
    PLoS ONE, 2011;6(7):e22261.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Dynamic interaction networks in a hierarchically organized tissue.
    Authors: Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW
    Mol. Syst. Biol., 2010;6(0):417.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells.
    Authors: Ghirelli C, Zollinger R, Soumelis V
    Blood, 2010;115(24):5037-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. IL-3 inhibits human osteoclastogenesis and bone resorption through downregulation of c-Fms and diverts the cells to dendritic cell lineage.
    Authors: Gupta N, Barhanpurkar AP, Tomar GB
    J. Immunol., 2010;185(4):2261-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
    Authors: Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE
    Blood, 2009;114(24):5091-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma.
    Authors: Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D
    Int. J. Cancer, 2009;125(5):1092-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
    Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(24):9826-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.
    Authors: Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, Cruz E, Pollok K, Cristina F, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N
    Exp. Hematol., 2008;36(5):545-558.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
    Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
    Exp. Hematol., 2008;36(8):1035-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15.
    Authors: McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS
    Exp. Hematol., 2008;36(5):598-608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
    Authors: Rajesh&lt;/LastName&gt;&lt;ForeNam D&lt;/Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
    Stem Cells, 2007;25(2):490-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis.
    Authors: Vassina EM, Yousefi S, Simon D, Zwicky C, Conus S, Simon HU
    Eur. J. Immunol., 2006;36(7):1975-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia.
    Authors: Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA
    Exp. Hematol., 2006;34(10):1312-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.
    Authors: Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y
    Exp. Hematol., 2006;34(6):760-9.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.
    Authors: Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S
    Cell Death Differ., 2006;13(10):1686-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. CD48 is an allergen and IL-3-induced activation molecule on eosinophils.
    Authors: Munitz A, Bachelet I, Eliashar R, Khodoun M, Finkelman FD, Rothenberg ME, Levi-Schaffer F
    J. Immunol., 2006;177(1):77-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells.
    Authors: Yokoi H, Myers A, Matsumoto K, Crocker PR, Saito H, Bochner BS
    Allergy, 2006;61(6):769-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005;23(8):1170-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines.
    Authors: Femenia F, Arock M, Leriche L, Delouis C, Millet G, Ben Hamouda N, Cote M, Alliot A, Lilin T, Pinton A, Iannucceli N, Parodi AL, Boireau P
    Life Sci., 2005;77(7):808-23.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Thrombospondin 1, produced by endothelial cells under the action of erythropoietin, stimulates thymidine incorporation into erythroid cells and counteracts the inhibitory action of insulin-like growth factor binding protein 3.
    Authors: Congote LF, DiFalco MR, Gibbs BF
    Cytokine, 2005;30(5):248-53.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells.
    Authors: Aldinucci D, 2019, Poletto D, Gloghini A, Nanni P, Degan M, Perin T, Ceolin P, Rossi FM, Gattei V, Carbone A, Pinto A
    439, 2002;160(2):585-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Prospective isolation of human clonogenic common myeloid progenitors.
    Authors: Manz MG, Miyamoto T, Akashi K, Weissman IL
    Proc. Natl. Acad. Sci. U.S.A., 2002;99(18):11872-7.
    Species: Human
    Sample Types:
    Applications: Bioassay
  142. Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells.
    Authors: Bug G, Rossmanith T, Henschler R, Kunz-Schughart LA, Schroder B, Kampfmann M, Kreutz M, Hoelzer D, Ottmann OG
    J. Leukoc. Biol., 2002;72(4):837-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
    Authors: Gomez-Navarro J, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM
    Gene Ther., 2000;7(1):43-52.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  144. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
    Authors: Shih CC, Hu MC, Hu J
    Blood, 2000;95(6):1957-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
    Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
    Blood, 1996;88(6):2013-25.
    Species: Human
    Sample Types:
    Applications: Bioassay
  146. Proliferating dendritic cell progenitors in human blood.
    Authors: Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, Konwalinka G, Fritsch P, Steinman R, Schuler G
    J Exp Med, 1994;180(1):83-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Can I reconstitute Recombinant Human IL-3 Protein (catalog # 203-IL) at a different concentration than recommended?

    • We cannot guarantee the performance if the protein is reconstituted at a different concentration than recommended in the product datasheet. Please contact Technical Service if you have any questions or concerns about reconstitution.

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Animal-Free Recombinant Proteins

Recombinant Human IL-3, Animal-Free Protein

AFL203
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Recombinant Human IL-3 Protein
By Anonymous on 11/20/2020
Application: Stem/Immune cell maintenance or differentiation
Recombinant Human IL-3 Protein
By Anonymous on 10/13/2020
Application: Stem/Immune cell maintenance or differentiation

It's good for hematopoietic colony formation.

Stem/Immune cell maintenance or differentiation Recombinant Human IL-3 Protein 203-IL
Recombinant Human IL-3 Protein
By Anonymous on 09/30/2020
Application: I used this human IL-3 for mast cells differentiation.
I used this human IL-3 for mast cells differentiation. Recombinant Human IL-3 Protein 203-IL