Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF Summary
Accession # Q8NHL6
Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera (Catalog #2017-T2) supports the adhesion of HSB2 humanperipheral blood acute lymphoblastic leukemia cells. Immobilized RecombinantHuman LILRB1/CD85j/ILT2 Fc Chimera at 5 µg/mL, 100 µL/well can support 60-80% HSB2cell adhesion, when 1 x 105 cells were added in each well of a 96-well plate.
LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family (1). Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs (2). Alternative splicing generates an additional isoform that lacks the transmembrane and cytoplasmic regions (3). LILRB1 is expressed on the surface of B cells and monocytes, as well as subsets of NK cells, memory/effector CD8+ T cells, gamma δ T cells, and monocyte-derived dendritic cells (3-7). LILRB1 binds to MHC-I as well as non-classical MHC-I molecules (e.g. HLA-F, HLA-G, and HC-B27) and the MHC-I mimetic UL18 encoded by cytomegalovirus (3, 5, 8-10). R&D Systems
in-house testing indicates that LILRB1 also binds to Angiopoietin-like 7. Ligation of LILRB1 inhibits the antigen induced proliferation and activation of CD8+ T cells, CD4+ T cells, NK cells, and gamma δ T cells (3, 4, 11-13). On dendritic cells, ligation inhibits the production of IL-10, IL-12p70, and TGF-beta and protects from Fas-mediated apoptosis (7).
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Citations for Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
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The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Nat Commun, 2016;7(0):11473.
Sample Types: Recombinant Protein
Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18.
Authors: Li N, Fu L, Uchtenhagen H, Achour A, Burshtyn D
Eur J Immunol, 2013;43(4):1042-52.
Sample Types: Protein
HLA-G inhibition of NK-cell cytolytic function is uncoupled from tumor cell lipid raft reorganization.
Authors: Baudhuin J, Lesport E, Sousa S, Migraine J, Vigneron J, LeMaoult J, Carosella ED, Mooney N, Favier B
Eur. J. Immunol., 2012;42(3):700-9.
Sample Types: Whole Cells
HLA-G expression in human embryonic stem cells and preimplantation embryos.
Authors: Verloes A, Van de Velde H, LeMaoult J
J. Immunol., 2011;186(4):2663-71.
Sample Types: Protein
Applications: Luminex Detection
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