Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF
Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF Summary
Accession # Q8NHL6
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family (1). Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs (2). Alternative splicing generates an additional isoform that lacks the transmembrane and cytoplasmic regions (3). LILRB1 is expressed on the surface of B cells and monocytes, as well as subsets of NK cells, memory/effector CD8+ T cells, gamma δ T cells, and monocyte-derived dendritic cells (3-7). LILRB1 binds to MHC-I as well as non-classical MHC-I molecules (e.g. HLA-F, HLA-G, and HC-B27) and the MHC-I mimetic UL18 encoded by cytomegalovirus (3, 5, 8-10). R&D Systems
in-house testing indicates that LILRB1 also binds to Angiopoietin-like 7. Ligation of LILRB1 inhibits the antigen induced proliferation and activation of CD8+ T cells, CD4+ T cells, NK cells, and gamma δ T cells (3, 4, 11-13). On dendritic cells, ligation inhibits the production of IL-10, IL-12p70, and TGF-beta and protects from Fas-mediated apoptosis (7).
- Thomas, R. et al. (2010) Clin. Rev. Allergy Immunol. 38:159.
- Samaridis, J. and M. Colonna (1997) Eur. J. Immunol. 27:660.
- Colonna, M. et al. (1997) J. Exp. Med. 186:1809.
- Harly, C. et al. (2011) Blood 117:2864.
- Cosman, D. et al. (1997) Immunity 7:273.
- Young, N.T. et al. (2001) J. Immunol. 166:3933.
- Young, N.T. et al. (2008) Blood 111:3090.
- Lepin, E.J.M. et al. (2000) Eur. J. Immunol. 30:3552.
- Shiroishi, M. et al. (2003) Proc. Natl. Acad. Sci. USA 100:8856.
- Allen, R.L. et al. (2001) J. Immunol. 167:5543.
- Ince, M.N. et al. (2004) Immunology 112:531.
- Saverino, D. et al. (2000) J. Immunol. 165:3742.
- Saverino, D. et al. (2002) J. Immunol. 168:207.
Citations for Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
Filter your results:
The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Nat Commun, 2016;7(0):11473.
Sample Types: Recombinant Protein
Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18.
Authors: Li N, Fu L, Uchtenhagen H, Achour A, Burshtyn D
Eur J Immunol, 2013;43(4):1042-52.
Sample Types: Protein
HLA-G inhibition of NK-cell cytolytic function is uncoupled from tumor cell lipid raft reorganization.
Authors: Baudhuin J, Lesport E, Sousa S, Migraine J, Vigneron J, LeMaoult J, Carosella ED, Mooney N, Favier B
Eur. J. Immunol., 2012;42(3):700-9.
Sample Types: Whole Cells
HLA-G expression in human embryonic stem cells and preimplantation embryos.
Authors: Verloes A, Van de Velde H, LeMaoult J
J. Immunol., 2011;186(4):2663-71.
Sample Types: Protein
Applications: Luminex Detection
No product specific FAQs exist for this product, however you mayView all Proteins and Enzyme FAQs
Reviews for Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF
There are currently no reviews for this product. Be the first to review Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF and earn rewards!
Have you used Recombinant Human LILRB1/CD85j/ILT2 Fc Chimera Protein, CF?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image