Recombinant Human PILR-beta Fc Chimera Protein, CF

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Recombinant Human PILR-beta Fc Chimera Protein Bioactivity
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Recombinant Human PILR-beta Fc Chimera Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. Recombinant Human CL-P1/COLEC12 (Catalog # 2690-CL) immobilized at 2 μg/mL, 100 μg/mL, can bind to Recombinant Human PILR‑ beta Fc Chimera with an ED50 of 0.12-0.72 μg/mL.
Human embryonic kidney cell, HEK293-derived human PILR-beta protein
Human PILR-beta
Accession # Q9UKJ0-1
Accession #
N-terminal Sequence
No results obtained. Gln20 predicted.
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
45.7 kDa (monomer)
57-66 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human PILR-beta Fc Chimera Protein Bioactivity View Larger

When Recombinant Human CL-P1/COLEC12 (Catalog # 2690-CL) is coated at 2 µg/mL, Recombinant Human PILR-beta Fc Chimera (Catalog # 9828-PR) binds with an ED50 of 0.12-0.72 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: PILR-beta

Paired immunoglobulin-like type 2 receptor beta (PILR-beta ) is a type I transmembrane (TM) glycoprotein belonging to the Ig superfamily. PILR-beta is the activating counterpart to the immunoreceptor tyrosine-based inhibitory motif (ITIM) containing PILR-alpha inhibitory receptor (1). Mature human PILR-beta is a 208 amino acid (aa) protein containing a 172 aa V-type Ig-like extracellular domain (ECD) with a siglec-like fold, a single TM, and a truncated cytoplasmic tail (2, 3). The TM of PILR-beta contains a positively-charged residue which interacts with immunoreceptor tyrosine-based activation (ITAM)-bearing adaptor molecules (2). The ECD of mature human PILR-beta shares 40% aa sequence identity with its mouse counterpart. PILR-beta is expressed on myeloid cells, such as natural killer, macrophage, and dendritic cells, as well as resident cells of the central nervous system, such as microglial cells (2,4). It is a binding partner for DAP12 and CD99, and has been shown to play an important role in innate immunity and inflammation (4-6). The PILR-alpha / beta pair have also been shown to regulate cell signaling via association with SHP-1 (7). Experiments studying the effects of S. aureus and T. gondii infections in mice have shown that up-regulation of PILR-beta led to significantly lower survival rates while knock-down of PILR-beta or activation of PILR-alpha resulted in significantly less inflammation and increased pathogen clearance (4,5).

  1. Wilson, M.D. et al. (2006) Physiol. Genomics 27:201.
  2. Shiratori, I. et al. (2004) J. Exp. Med. 199:525.
  3. Lu, Q. et al. (2014) PNAS 111:8221.
  4. Tato, C.M. et al. (2012) PLoS One 7:e31690.
  5. Banerjee, A. et al. (2010) Infect. Immun. 78:1353.
  6. Tabata, S. et al. (2008) J. Biol. Chem. 283:8893.
  7. Mousseau, DD. et al. (2000) J. Biol. Chem. 275:4467.
Long Name
Paired-Ig-likeType 2 Receptor beta
Entrez Gene IDs
29990 (Human); 170741 (Mouse)
Alternate Names
activating receptor PILRbeta; Activating receptor PILR-beta; Cell surface receptor FDFACT; cell surface receptor FDFACT1; cell surface receptor FDFACT2; FDFACT; FDFACT1; FDFACT2; paired immunoglobin-like receptor beta; paired immunoglobin-like type 2 receptor beta; paired immunoglobulin-like receptor beta; paired immunoglobulin-like type 2 receptor beta; PILRB; PILRbeta; PILR-beta


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