Recombinant Human Tau Protein, CF

R&D Systems | Catalog # SP-495

R&D Systems
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Key Product Details

  • R&D Systems E. coli-derived Recombinant Human Tau Protein (SP-495)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

E. coli

Accession Number

NP_005901.2

Applications

Bioactivity
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Product Specifications

Source

E. coli-derived human Tau protein

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Predicted Molecular Mass

46 kDa

Activity

Concentrations for in vitro assays will depend on experimental conditions and detection methods.

Formulation, Preparation, and Storage

SP-495
Formulation Supplied as a solution in PBS.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: Tau

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  There are multiple forms of Tau--this 441 amino acid isoform is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441" and is referenced in UniProt as P10636-8.  This recombinant protein is untagged.

References

  1. Billingsley M.L. & Kincaid R.L. (1997)  Biochem. J.  323: 577
  2. Bloom G.S. (2014) JAMA Neurol.  71: 505
  3. Cripps D. et al. (2006) J. Biol. Chem.  281: 10825
  4. Harada A. et al (1994)  Nature  369: 488
  5. Lei P. et al. (2010)  Int. J. Biochem. Cell Biol.  42: 1775
 

Long Name

Microtubule-Associated Protein Tau

Alternate Names

MAPT, MSTD, MTBT1, Neurofibrillary tangle protein, PPND

Entrez Gene IDs

4137 (Human); 17762 (Mouse); 29477 (Rat)

Gene Symbol

MAPT

UniProt

NP_005901.2

Additional Tau Products

Product Documents for Recombinant Human Tau Protein, CF

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Recombinant Human Tau Protein, CF

For research use only

Citations for Recombinant Human Tau Protein, CF

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FAQs for Recombinant Human Tau Protein, CF

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  • Q: Is Recombinant Human Tau (Catalog # SP-495) phosphorylated?

    A: No. Recombinant Human Tau (Catalog # SP-495), which is produced in E.coli, is not phosphorylated.

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