Recombinant Human Tau Protein, CF
Recombinant Human Tau Protein, CF Summary
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||X mg/ml (X μM) in PBS pH 7.4|
|Shipping||The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Tau is a microtubule-associated protein expressed primarily in neurons. Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane. Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases. Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death. There are multiple forms of Tau--this 441 amino acid isoform is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441" and is referenced in UniProt as P10636-8. This recombinant protein is untagged.
- Billingsley M.L. & Kincaid R.L. (1997) Biochem. J. 323: 577
- Bloom G.S. (2014) JAMA Neurol. 71: 505
- Cripps D. et al. (2006) J. Biol. Chem. 281: 10825
- Harada A. et al (1994) Nature 369: 488
- Lei P. et al. (2010) Int. J. Biochem. Cell Biol. 42: 1775
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