Recombinant Human Transglutaminase 1/TGM1 Protein, CF
Recombinant Human Transglutaminase 1/TGM1 Protein, CF Summary
Met2-Ala817, with an N-terminal Met and 6-His tag
Background: Transglutaminase 1/TGM1
Transglutaminase 1, also known as TGM1, Transglutaminase K, keratinocyte transglutaminase, or epidermal TGase, is a member of the transglutaminase family. Transglutaminases catalyze the calcium-dependent formation of isopeptide bonds between lysine and glutamine residues (1). TGM1 plays an important role in formation of the cornified envelope of differentiating keratinocytes in the epidermis through its cross-linking of epidermal proteins (2). The majority of cases of lamellar ichthyosis result from mutations present within the TGM1 gene and the subsequent dysfunction of TGM1 (1, 3).
- Lorand, L. and R.M. Graham (2003) Nature Rev. Mol. Cell. Biol. 4:140.
- Eckert, R.L. et al. (2005) J. Invest. Dermatol. 124:481.
- Farasat, S. et al. (2009) J. Med. Genet. 46:103.
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