Transglutaminase 1/TGM1: Products

The principal activity of transglutaminases (TGMs) is to catalyze the Ca2+-dependent formation of an isopeptide bond between the gamma-carboxamide group of a glutaminyl residue and the epsilon-amino group of a lysyl residue.

TGM1, also known as keratinocyte and epidermal transglutaminase, is responsible for the crosslinking of epidermal proteins during the formation of the stratum corneum. Mutations of TGM1 result in a number of skin diseases, notably ichthyosis lamellar type 1.5 TGM1 exists both as a cell surface protein tethered to the plasma membrane through lipid modifications or as a soluble protein that is released from the membrane by proteolysis.

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