Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF

R&D Systems | Catalog # 859-DK

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Key Product Details

  • R&D Systems NS0-derived Recombinant Human Tyro3/Dtk Fc Chimera Protein (859-DK)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

NS0

Accession Number

Q06418

Structure / Form

Disulfide-linked homodimer

Applications

Binding Activity
View all Tyro3/Dtk Proteins and Enzymes »

Product Specifications

Source

Mouse myeloma cell line, NS0-derived human Tyro3/Dtk protein
Human Tyro3/Dtk
(Ala41-Ser428)
Accession # Q06418		 DIEGRMD Human IgG1
(Pro100-Lys330)		 6-His tag
N-terminus C-terminus

Purity

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala41

Predicted Molecular Mass

69 kDa (monomer)

SDS-PAGE

100-110 kDa, reducing conditions

Activity

Measured by its binding ability in a functional ELISA.
Immobilized Recombinant Human Tyro3/Dtk Fc Chimera at 2 µg/mL (100 µL/well) can bind Recombinant Human Gas6 (Catalog # 885-GSB) with a linear range of 2-100 ng/mL.

Reviewed Applications

Read 3 reviews rated 5 using 859-DK in the following applications:

Formulation, Preparation, and Storage

859-DK
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Tyro3/Dtk

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.

References

  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.

Long Name

Tyrosine Protein Kinase Receptor TYRO3

Alternate Names

Brt, Dtk, Rse, Sky

Entrez Gene IDs

7301 (Human); 22174 (Mouse); 102135978 (Cynomolgus Monkey)

Gene Symbol

TYRO3

UniProt

Q06418

Additional Tyro3/Dtk Products

Product Documents for Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF

For research use only

Citations for Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF

Customer Reviews for Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF (3)

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  • Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF
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    Application: Binding assay/Protein-protein interaction
    Verified Customer | Posted 03/30/2025
  • Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF
    Name: Anonymous
    Application: Binding assay/Protein-protein interaction
    Verified Customer | Posted 04/03/2018
    Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF 859-DK
  • Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF
    Name: Anonymous
    Application: Binding assay/Protein-protein interaction
    Verified Customer | Posted 03/21/2018
    Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF 859-DK

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