Recombinant Human VSIG3 Fc Chimera Protein, CF Summary
|Human VSIG3 |
Accession # BAC07546
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 200 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Recombinant Human VSIG3 Fc Chimera (Catalog # 9229-VS)inhibits anti-CD3 antibody induced IL-17 secretion in human PBMC. TheED50 for this effect is 1-6 μg/mL.
VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is an approximately 50 kDa transmembrane adhesion protein (1). Mature human VSIG3 consists of a 219 amino acid (aa) extracellular domain (ECD) that contains two tandem Ig-like domains, a 21 aa transmembrane segment, and a 169 aa cytoplasmic domain (2). Within the ECD, human VSIG3 shares 95% aa sequence identity with mouse and rat VSIG3. Alternative splicing generates additional isoforms with a substituted signal peptide that may also have a deletion in the second Ig-like domain (3). VSIG3 is expressed on epithelial and endothelial cells, neurons and glial cells, and platelets (2-4). It localizes to epithelial tight junctions and mediates homophilic in trans cell adhesion (3-5). VSIG3 also localizes to neuronal postsynaptic densisties where it recruits the GluA1 and GluA2 subunits of AMPA receptors and supports excitatory synaptic transmission (6). The short isoform can be up-regulated in gastric cancer (7). In zebrafish, VSIG3 is expressed in melanophores and their precursors and plays a role in the development and patterning of pigment cells (8).
- Schreiber, J. et al. (2014) Adv. Neurobiol. 8:21.
- Suzu, S. et al. (2002) Biochem. Biophys. Res. Commun. 296:1215.
- Katoh, M. and M. Katoh (2003) Int. J. Oncol. 23:525.
- Raschperger, E. et al. (2004) J. Biol. Chem. 279:796.
- Harada, H. et al. (2005) J. Cell. Physiol. 204:919.
- Jang, S. et al. (2016) Nat. Neurosci. 19:84.
- Watanabe, T. et al. (2005) Cancer Sci. 96:498.
- Eom, D.S. et al. (2012) PLoS Genet. 8:e1002899.
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