Recombinant Mouse CCL2/JE/MCP-1 Protein, CF

(58 citations)   
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR2A. The ED50 for this effect is 2-10 ng/mL. Measured by its ability to chemoattract 2-day cultured human monocytes. Matsushima, K. et al. (1989) J. Exp. Med. 169:1485. The ED50 for this effect is 5-20 ng/mL.
  • Source
    E. coli-derived Gln24-Arg96
  • Accession #
  • N-terminal Sequence
    Analysis
    Gln24
  • Predicted Molecular Mass
    8.5 kDa
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
479-JE/CF
 
479-JE
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Mouse CCL2/JE/MCP-1 (Catalog # 479-JE/CF) chemoattracts the BaF3 mouse pro-B cell line transfected with human CCR2A. The ED50 for this effect is 2-10 ng/mL.
1 μg/lane of Recombinant Mouse CCL2/JE/MCP-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band at 8 kDa.
Background: CCL2/JE/MCP-1

CCL2, also called monocyte chemotactic protein-1 (MCP-1) or JE, is a member of the C-C or beta  chemokine family that is best known as a chemotactic agent for mononuclear cells (1, 2). Mouse CCL2 cDNA encodes a 148 amino acid (aa) precursor protein with a 23 aa signal peptide and a 125 aa mature protein (1). Removal of the first 5 aa of the mature protein, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, occurs naturally by metalloproteinase cleavage and downregulates activity but not receptor binding (3). Mouse CCL2 forms a broad band around 25 kDa on SDS-PAGE due to non-covalent dimerization and variable carbohydrate content (1). Mouse and rat express a form of CCL2 that is extended by 49 aa compared to other species. Mature mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively, over aa 24 ‑ 101.  Human CCL2 can, however, induce a limited response in rodent cells, and mouse CCL2 has full activity on human cells (2, 4). Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source (1, 2). In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2 (2). Additionally, it promotes Th2 polarization in CD4+ T cells (5). CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma (6, 7). When a DNA sequence encoding the 125 aa residue of the mature CCL2 protein was expressed in E. coli at R&D Systems, the purified protein had the predicted N-terminus but a mass of 8525 Da. The truncation of most of the C-terminal extension could be due either to purification artifact or to post-translational modification. The truncated recombinant CCL2 has a potency similar to that of human MCP-1 in the monocyte chemotaxis assay.

  • References:
    1. Rollins, B.J. et al. (1988) Proc. Natl. Acad. Sci. USA. 85:3738.
    2. Deshmane, S.L. et al. (2009) J. Interferon Cytokine Res. 29:313.
    3. Dean, R.A. et al. (2008) Blood. 112:3455.
    4. Van Riper, G. et al. (1993) J. Exp. Med. 177:851.
    5. Luther, S.A. and J.G. Cyster (2001) Nat. Immunol. 2:102.
    6. Daly, C. et al. (2003) Microcirculation 10:247.
    7. Aukrust, P. et al. (2008) Arterioscler. Thromb. Vasc. Biol. 28:1909.
  • Entrez Gene IDs:
    6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
  • Alternate Names:
    CCL2; MCAF; MCP-1
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

58 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo
    Authors: N Lavender, J Yang, SC Chen, J Sai, CA Johnson, P Owens, GD Ayers, A Richmond
    BMC Cancer, 2017;17(1):88.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Scavenger receptor A1 prevents metastasis of non-small cell lung cancer via suppression of macrophage serum amyloid A1
    Authors: Y Zhang, Y Wei, B Jiang, L Chen, H Bai, X Zhu, X Li, H Zhang, Q Yang, J Ma, Y Xu, J Ben, DC Christiani, Q Chen
    Cancer Res, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung
    Authors: H Nakano, MR Lyons-Cohe, GS Whitehead, K Nakano, DN Cook
    J. Leukoc. Biol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
    Nat Commun, 2016;7(0):13781.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
    Mucosal Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  6. High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis
    Authors: Cong Lin
    J Cell Mol Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice
    Authors: T Wang, Z Wang, P Yang, L Xia, M Zhou, S Wang, J Du, J Zhang
    Cell Death Dis, 2016;7(0):e2176.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. Platelets Guide Leukocytes to Their Sites of Extravasation
    PLoS Biol, 2016;14(5):e1002459.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  9. Combined effect of insulin-like growth factor-1 and CC chemokine ligand 2 on angiogenic events in endothelial cells.
    Authors: Viana I, de Almeida M, Lins M, dos Santos Reis M, de Araujo Vieira L, Smaniotto S
    PLoS ONE, 2015;10(4):e0121249.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration.
    Authors: Eguchi A, Mulya A, Lazic M, Radhakrishnan D, Berk M, Povero D, Gornicka A, Feldstein A
    PLoS ONE, 2015;10(4):e0123110.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. Murine IL-17+ Vgamma4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis.
    Authors: Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, Benjamim C, Penido C
    BMC Immunol, 2015;16(0):36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.
    Authors: Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J
    J Exp Med, 2014;211(10):1957-68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
    Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
    Stem Cells, 2014;32(5):1347-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Defective TGF-beta signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors.
    Authors: Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder M, Kaplan M, Xie J
    Cancer Res, 2014;74(2):471-83.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
    Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
    Nat Med, 2014;20(4):377-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. Technical advance: monitoring the trafficking of neutrophil granulocytes and monocytes during the course of tissue inflammation by noninvasive 19F MRI.
    Authors: Temme S, Jacoby C, Ding Z, Bonner F, Borg N, Schrader J, Flogel U
    J Leukoc Biol, 2014;95(4):689-97.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  17. CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy.
    Authors: Menichella D, Abdelhak B, Ren D, Shum A, Frietag C, Miller R
    Mol Pain, 2014;10(0):42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion.
    Authors: Fleetwood A, Achuthan A, Schultz H, Nansen A, Almholt K, Usher P, Hamilton J
    J Immunol, 2014;192(8):3540-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.
    Authors: Kallis, Yiannis, Scotton, Christop, Mackinnon, Alison C, Goldin, Robert D, Wright, Nicholas, Iredale, John P, Chambers, Rachel C, Forbes, Stuart J
    PLoS ONE, 2014;9(1):e86241.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney.
    Authors: Sato S, Zhang X
    Clin Exp Immunol, 2014;177(1):102-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection.
    Authors: Bowcutt, R, Bramhall, M, Logunova, L, Wilson, J, Booth, C, Carding, S R, Grencis, R, Cruickshank, S
    Mucosal Immunol, 2014;7(5):1094-105.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. Deletion of class A scavenger receptor deteriorates obesity-induced insulin resistance in adipose tissue.
    Authors: Zhu, Xudong, Zong, Guijuan, Zhu, Liu, Jiang, Yuchen, Ma, Ke, Zhang, Hanwen, Zhang, Yan, Bai, Hui, Yang, Qing, Ben, Jingjing, Li, Xiaoyu, Xu, Yong, Chen, Qi
    Diabetes, 2014;63(2):562-77.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
    Authors: Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T
    J Immunol, 2014;192(1):407-17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: cell culture
  24. Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
    Authors: Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K
    PLoS ONE, 2013;8(11):e80500.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention.
    Authors: Wanschel, Amarylis, Seibert, Tara, Hewing, Bernd, Ramkhelawon, Bhama, Ray, Tathagat, van Gils, Janine M, Rayner, Katey J, Feig, Jonathan, O'Brien, Edward R, Fisher, Edward A, Moore, Kathryn
    Arterioscler Thromb Vasc Biol, 2013;33(5):886-93.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.
    Authors: Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM
    J. Leukoc. Biol., 2011;89(2):269-82.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy.
    Authors: Guerrot D, Kerroch M, Placier S, Vandermeersch S, Trivin C, Mael-Ainin M, Chatziantoniou C, Dussaule JC
    Am. J. Pathol., 2011;179(1):83-91.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  28. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
    Authors: Kim HS, Go H, Akira S, Chung DH
    J. Immunol., 2011;187(8):4007-17.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  29. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
    Authors: Koth LL, Cambier CJ, Ellwanger A
    J. Immunol., 2010;184(11):6522-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice.
    Authors: Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M
    Endocrinology, 2010;151(3):971-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  31. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression.
    Authors: Fujimoto H, Sangai T, Ishii G, Ikehara A, Nagashima T, Miyazaki M, Ochiai A
    Int. J. Cancer, 2009;125(6):1276-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.
    Authors: Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ, Park JY, Lind AL, Ma Q, Ji RR
    J. Neurosci., 2009;29(13):4096-108.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  33. Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice.
    Authors: Lafdil F, Chobert MN, Deveaux V, Zafrani ES, Mavier P, Nakano T, Laperche Y, Brouillet A
    J. Hepatol., 2009;51(1):55-66.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008;125(2):272-9.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  35. Histone H2B as a functionally important plasminogen receptor on macrophages.
    Authors: Das R, Burke T, Plow EF
    Blood, 2007;110(10):3763-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.
    Authors: Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA
    Am. J. Respir. Cell Mol. Biol., 2007;37(2):248-53.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
    Authors: Kang JH, Kim CS, Han IS, Kawada T, Yu R
    FEBS Lett., 2007;581(23):4389-96.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis.
    Authors: Yamauchi LM, Aliberti JC, Baruffi MD, Portela RW, Rossi MA, Gazzinelli RT, Mineo JR, Silva JS
    Microbes Infect., 2007;9(1):111-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  39. Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway.
    Authors: Penido C, Costa MF, Souza MC, Costa KA, Candea AL, Benjamim CF, Henriques MG
    Int. Immunol., 2007;20(1):129-39.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  40. High pressure promotes monocyte adhesion to the vascular wall.
    Authors: Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S
    Circ. Res., 2007;100(8):1226-33.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  41. Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
    Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
    Nature, 2007;450(7171):825-31.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury.
    Authors: Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA
    J. Immunol., 2006;177(1):612-20.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  43. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.
    Authors: Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, Stratis A, Renkl AC, Sunderkotter C, Wlaschek M, Haase I, Scharffetter-Kochanek K
    J. Clin. Invest., 2006;116(8):2105-14.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  44. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006;177(3):1967-74.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  45. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines.
    Authors: Rhodes KE, Raivich G, Fawcett JW
    Neuroscience, 2006;140(1):87-100.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  46. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005;302(1):172-81.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  47. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
    Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
    Am. J. Respir. Cell Mol. Biol., 2005;33(3):248-53.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
    Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
    Brain, 2005;128(0):854-66.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  49. The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
    Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
    Blood, 2005;105(1):31-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons.
    Authors: Gonzalez de Aguilar JL, Dupuis L, Larmet Y
    Neurobiol. Dis., 2005;19(1):129-41.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.
    Authors: Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA
    Blood, 2004;104(5):1404-10.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  52. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2004;231(1):103-11.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  53. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.
    Authors: Hieshima K, Ohtani H, Shibano M, Izawa D, Nakayama T, Kawasaki Y, Shiba F, Shiota M, Katou F, Saito T, Yoshie O
    J. Immunol., 2003;170(3):1452-61.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.
    Authors: Bruemmer D, Collins AR, Noh G, Wang W, Territo M, Arias-Magallona S, Fishbein MC, Blaschke F, Kintscher U, Graf K, Law RE, Hsueh WA
    J. Clin. Invest., 2003;112(9):1318-31.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  55. IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1.
    Authors: Russell TD, Yan Q, Fan G, Khalifah AP, Bishop DK, Brody SL, Walter MJ
    J. Immunol., 2003;171(12):6866-74.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  56. Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guerin.
    Authors: Penido C, Vieira-de-Abreu A, Bozza MT, Castro-Faria-Neto HC, Bozza PT
    J. Immunol., 2003;171(12):6788-94.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  57. Possible co-regulation of genes associated with enhanced progression of mammary adenocarcinomas.
    Authors: Neumark E, Cohn MA, Lukanidin E, Witz IP, Ben-Baruch A
    Immunol. Lett., 2002;82(1):111-21.
    Species: Mouse
    Sample Type: Cell Culture Supernates
    Application: Bioassay
  58. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.
    Authors: Maus UA, Koay MA, Delbeck T, Mack M, Ermert M, Ermert L, Blackwell TS, Christman JW, Schlondorff D, Seeger W, Lohmeyer J
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002;282(6):L1245-52.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
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