Recombinant Mouse IL-12 Protein

Carrier Free

Catalog # Availability Size / Price Qty
419-ML-010/CF
419-ML-050/CF
419-ML-500/CF

With Carrier

Catalog # Availability Size / Price Qty
419-ML-010
419-ML-050
419-ML-500
Recombinant Mouse IL-12 Protein Data
2 Images
Product Details
Citations (205)
FAQs
Reviews (7)

Recombinant Mouse IL-12 Protein Summary

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using PHA-activated mouse splenocytes. Mattner, F. et al. (1993) Eur. J. Immunol. 23:2202. The ED50 for this effect is 0.01-0.1 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived mouse IL-12 protein
Mouse IL-12 p40
(Met23-Ser335)
Accession # P43432
Mouse IL-12 p35
(Arg23-Ala215)
Accession # NP_032377
N-terminus C-terminus
N-terminal Sequence
Analysis

Met23 (p40) & Arg23 (p35)

Structure / Form
Disulfide-linked heterodimer
SDS-PAGE
70 kDa, non-reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

419-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

419-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity View Larger

Recombinant Mouse IL-12 (Catalog # 419-ML) stimulates cell proliferation of PHA-activated mouse splenocytes. The ED50for this effect is 0.01‑0.1 ng/mL.

SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse IL-12 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing bands at 25 kDa and 43 kDa (R) and 68 kDa (NR).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-12

Interleukin 12, also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL‑12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL‑12 activities include the induction of IFN‑ gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL‑12 is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL‑12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent.

Human and mouse IL‑12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. While mouse IL‑12 is active on both human and mouse cells, human IL‑12 is not active on murine cells. R&D Systems' recombinant mouse IL‑12 preparations were proteolytically cleaved between residues G158 and E159 of the mature p35 subunit. Thus, under reducing conditions, three bands representing the p40 subunit, the p35 R1 ‑ G158 peptide and the p35 E159 - A193 peptide can be observed in SDS-PAGE. The biological activity of this cleaved mouse IL‑12 is comparable to that of the intact human IL‑12.

Long Name
Interleukin 12
Entrez Gene IDs
3592 (Human); 16159 (Mouse); 84405 (Rat); 403977 (Canine); 102115316 (Cynomolgus Monkey); 493741 (Feline); 703205 (Rhesus Macaque)
Alternate Names
CLMF p35; CLMF1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL12; IL-12; IL-12, subunit p35; IL12A; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, 35 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF1; p35

Citations for Recombinant Mouse IL-12 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

205 Citations: Showing 1 - 10
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  1. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg
    Authors: JS Dolina, J Lee, RQ Griswold, L Labarta-Ba, S Kannan, JA Greenbaum, N Bahia El I, MJ Pont, M Croft, SP Schoenberg
    Cell Rep, 2020;31(1):107249.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. TLR4 abrogates the Th1 immune response through IRF1 and IFN-&beta to prevent immunopathology during L. infantum infection
    Authors: LA Sacramento, L Benevides, SR Maruyama, L Tavares, KF Fukutani, M Francozo, T Sparwasser, FQ Cunha, RP Almeida, JS da Silva, V Carregaro
    PLoS Pathog., 2020;16(3):e1008435.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells
    Authors: S Steinmann, M Schoedsack, F Heinrich, PC Breda, A Ochel, G Tiegs, K Neumann
    Sci Rep, 2020;10(1):1071.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
    Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
    J. Leukoc. Biol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function
    Authors: TA Mace, MB Ware, SA King, S Loftus, MR Farren, E McMichael, S Scoville, C Geraghty, G Young, WE Carson, SK Clinton, GB Lesinski
    Sci Rep, 2019;9(1):5068.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  6. IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection
    Authors: P Kumar, K Rajasekara, A Nanbakhsh, J Gorski, MS Thakar, S Malarkanna
    Sci Rep, 2019;9(1):4984.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity
    Authors: M Ott, E Avendaño-G, E Ullrich, C Dreyer, J Strauss, M Harden, M Schön, MP Schön, G Bernhardt, C Stadelmann, C Wegner, W Brück, S Nessler
    J Neuroinflammation, 2019;16(1):49.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism
    Authors: C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella
    Cell Rep, 2019;27(5):1434-1445.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
    Authors: N Simonovi?, A Witalisz-S, K Meissl, C Lassnig, U Reichart, T Kolbe, M Farlik, C Bock, V Sexl, M Müller, B Strobl
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development
    Authors: Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu
    EBioMedicine, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C
    Authors: TS Abraham, JC Flickinger, SA Waldman, AE Snook
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. KLF12 Regulates Mouse NK Cell Proliferation
    Authors: VC Lam, L Folkersen, OA Aguilar, LL Lanier
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis
    Authors: KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance
    Authors: JK Fiege, IA Stone, RE Dumm, BM Waring, BT Fife, J Agudo, BD Brown, NS Heaton, RA Langlois
    PLoS Pathog., 2019;15(9):e1008077.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells
    Authors: LP Araujo, JT Maricato, MG Guereschi, MC Takenaka, VM Nascimento, FM de Melo, FJ Quintana, PC Brum, AS Basso
    Cell Rep, 2019;28(12):3120-3130.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. The combination of Cytokines and albendazole therapy for prophylaxis and treatment of experimental./hydatid cyst
    Authors: M Rahdar, A Rafiei, R Valipour-N
    Acta Trop., 2019;201(0):105206.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  17. IL-12 signaling drives the differentiation and function of a TH1-derived TFH1-like cell population
    Authors: MD Powell, KA Read, BK Sreekumar, DM Jones, KJ Oestreich
    Sci Rep, 2019;9(1):13991.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation
    Authors: C Zhang, BJE Raveney, H Hohjoh, C Tomi, S Oki, T Yamamura
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
    Authors: OE Weizman, E Song, NM Adams, AD Hildreth, L Riggan, C Krishna, OA Aguilar, CS Leslie, JR Carlyle, JC Sun, TE O'Sullivan
    Nat. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
    Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
    Nat Commun, 2019;10(1):549.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease
    Authors: HC Chuang, CY Tsai, CH Hsueh, TH Tan
    Sci Adv, 2018;4(9):eaat5401.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection
    Authors: CD Geary, C Krishna, CM Lau, NM Adams, SV Gearty, Y Pritykin, AR Thomsen, CS Leslie, JC Sun
    Cell Rep, 2018;24(8):1949-1957.e6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit
    Authors: P Garnier, R Mummery, MJ Forster, B Mulloy, RV Gibbs, CC Rider
    Cytokine, 2018;110(0):159-168.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  24. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
    Authors: V Jelen?i?, M Šestan, I Kavazovi?, M Lenarti?, S Marinovi?, TD Holmes, M Prchal-Mur, B Lisni?, V Sexl, YT Bryceson, FM Wensveen, B Poli?
    Nat. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
    Authors: M Zhao, MND Svensson, K Venken, A Chawla, S Liang, I Engel, P Mydel, J Day, D Elewaut, N Bottini, M Kronenberg
    Nat Commun, 2018;9(1):2627.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Hexokinase II may be dispensable for CD4 T cell responses against a virus infection
    Authors: SK Varanasi, U Jaggi, N Hay, BT Rouse
    PLoS ONE, 2018;13(1):e0191533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance
    Authors: J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont
    Cell Rep, 2018;25(12):3329-3341.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. CD4+ T cell-mediated rejection of MHC class II-positive tumor cells is dependent on antigen secretion and indirect presentation on host APCs
    Authors: OAW Haabeth, M Fauskanger, M Manzke, KU Lundin, A Corthay, B Bogen, AA Tveita
    Cancer Res., 2018;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. A new RelB-dependent CD117+CD172a+murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo
    Authors: N Andreas, M Riemann, CN Castro, M Groth, I Koliesnik, C Engelmann, T Sparwasser, T Kamradt, R Haenold, F Weih
    Eur. J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection
    Authors: T Nabekura, Z Chen, C Schroeder, T Park, E Vivier, LL Lanier, D Liu
    J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
    Authors: SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types:
  32. Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis
    Authors: AM Falcão, D van Brugge, S Marques, M Meijer, S Jäkel, E Agirre, Samudyata, EM Floriddia, DP Vanichkina, C Ffrench-Co, A Williams, AO Guerreiro-, G Castelo-Br
    Nat. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
    Authors: L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
    Cell Rep, 2018;25(11):3059-3073.e10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Targeting tumor�vasculature�with TNF leads effector T cells to the tumor and enhances therapeutic efficacy of immune checkpoint blockers in combination with ACT
    Authors: AR Elia, M Grioni, V Basso, F Curnis, M Freschi, A Corti, A Mondino, M Bellone
    Clin. Cancer Res., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
    Authors: CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, X Chen, J Xiao, A Fisher, WJ Kaiser, MA Murayama, Y Iwakura, J Gao, J Carman, A Dongre, G Dubyak, DW Abbott, FD Shi, RM Ransohoff, X Li
    J. Clin. Invest., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. REV-ERB? Regulates TH17 Cell Development and Autoimmunity
    Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
    Cell Rep, 2018;25(13):3733-3749.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells
    Authors: J Choi, DR Pease, S Chen, B Zhang, H Phee
    Immunology, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection
    Authors: S Raju, K Kometani, T Kurosaki, AS Shaw, T Egawa
    PLoS Pathog., 2018;14(5):e1007053.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Reprograming Immunity to Food Allergens
    Authors: AL St John, GWX Ang, APS Rathore, SN Abraham
    J. Allergy Clin. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Nanoparticles
    Applications: In Vivo
  40. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
    Authors: IJ Jensen, CS Winborn, MG Fosdick, P Shao, MM Tremblay, Q Shan, SK Tripathy, CM Snyder, HH Xue, TS Griffith, JC Houtman, VP Badovinac
    PLoS Pathog., 2018;14(10):e1007405.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
    Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
    Immunity, 2018;48(3):556-569.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance
    Authors: D Daley, VR Mani, N Mohan, N Akkad, A Ochi, DW Heindel, KB Lee, CP Zambirinis, GSB Pandian, S Savadkar, A Torres-Her, S Nayak, D Wang, M Hundeyin, B Diskin, B Aykut, G Werba, RM Barilla, R Rodriguez, S Chang, L Gardner, LK Mahal, B Ueberheide, G Miller
    Nat. Med., 2017;23(5):556-567.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
    Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
    Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells
    Authors: R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis
    Authors: ERO Allan, RI Campden, BW Ewanchuk, P Tailor, DR Balce, NT McKenna, CJ Greene, AL Warren, T Reinheckel, RM Yates
    J Neuroinflammation, 2017;14(1):103.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity
    Authors: AM Westendorf, K Skibbe, A Adamczyk, J Buer, R Geffers, W Hansen, E Pastille, V Jendrossek
    Cell. Physiol. Biochem, 2017;41(4):1271-1284.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Suppression of murine tumor growth through CD8(+) CTLs via activated DEC-205(+) dendritic cells by sequential administration of ?-galactosylceramide in vivo
    Authors: H Kogo, M Shimizu, Y Negishi, F Uchida, H Takahashi
    Immunology, 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  51. Generating the Abscopal Effect by Combining Proapoptotic Peptides With IL-12-Based Immunotherapy
    Authors: F Martins, G Stalder, M Obeid
    Neoplasia, 2017;20(2):193-196.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  52. Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells
    Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
    J. Allergy Clin. Immunol., 2017;139(5):1608-1620.e3.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  53. BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency
    Authors: B Afzali, J Grönholm, J Vandrovcov, C O'Brien, HW Sun, I Vanderleyd, FP Davis, A Khoder, Y Zhang, AN Hegazy, AV Villarino, IW Palmer, J Kaufman, NR Watts, M Kazemian, O Kamenyeva, J Keith, A Sayed, D Kasperavic, M Mueller, JD Hughes, IJ Fuss, MF Sadiyah, K Montgomery, J McElwee, NP Restifo, W Strober, MA Linterman, PT Wingfield, HH Uhlig, R Roychoudhu, TJ Aitman, P Kelleher, MJ Lenardo, JJ O'Shea, N Cooper, ADJ Laurence
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells
    Authors: KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target.
    Authors: Jonas J Staudacher, Cemal Yazici, Timothy Carroll, Jessica Bauer, Jingbo Pang, Nancy Krett, Yinglin Xia, Annette Wilson, Georgios Papachris, Andrea Dirmeier, Claudia Kunst, David C Whitcomb, Giamila Fantuzzi, Barbara Jung
    Scientific Reports, 2017;0(0):2045-2322.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  56. Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4(+) memory T cells
    Authors: BA Szilagyi, J Triebus, C Kressler, M de Almeida, S Tierling, P Durek, M Mardahl, A Szilagyi, S Floess, J Huehn, U Syrbe, J Walter, JK Polansky, A Hamann
    Mucosal Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis
    Authors: MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):E524-E533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor
    Authors: K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao
    Cell Mol Gastroenterol Hepatol, 2017;4(1):135-151.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
    Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells
    Authors: J Chen, JL Martindale, C Cramer, M Gorospe, U Atasoy, PD Drew, S Yu
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Armc5 deletion causes developmental defects and compromises T-cell immune responses
    Authors: Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu
    Nat Commun, 2017;8(0):13834.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties
    Authors: A Van Acker, K Gronke, A Biswas, L Martens, Y Saeys, J Filtjens, S Taveirne, E Van Ammel, T Kerre, P Matthys, T Taghon, B Vandekerck, J Plum, IR Dunay, A Diefenbach, G Leclercq
    Cell Rep, 2017;19(7):1431-1443.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
    Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice
    Authors: CM Larabee, Y Hu, S Desai, C Georgescu, JD Wren, RC Axtell, SM Plafker
    Mol Vis, 2016;22(0):332-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
    Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
    Eur J Immunol, 2016;46(1):212-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis
    Authors: C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Immune signatures of protective spleen memory CD8 T cells
    Sci Rep, 2016;6(0):37651.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness
    Authors: P Holmkvist, L Pool, K Hägerbrand, WW Agace, A Rivollier
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease
    Proc. Natl. Acad. Sci. U.S.A., 2016;113(12):3323-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy
    Authors: Yedi Zhou
    Sci Rep, 2016;6(0):28140.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  73. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
    Nat Commun, 2016;7(0):11626.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016;6(0):38387.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Inflammation enhances the vaccination potential of CD40-activated B cells in mice
    Eur. J. Immunol., 2016;0(0):2016.
    Species: Mouse
    Sample Types: In Vivo
  76. Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2
    Authors: U Schulze-To, M Varrin-Doy, K Pekarek, CM Spencer, A Shetty, SA Sagan, BA Cree, RA Sobel, BT Wipke, L Steinman, RH Scannevin, SS Zamvil
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
    PLoS ONE, 2016;11(5):e0155953.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Adaptive immunity against gut microbiota enhances apoE-mediated immune regulation and reduces atherosclerosis and western-diet-related inflammation
    Sci Rep, 2016;6(0):29353.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  79. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator.
    Authors: Chang M, Chen Y, Chiang Y, Chen T, Tang Y, Chen C, Sun W, Cheng W
    Gene Ther, 2016;23(1):38-49.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  81. RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
    Authors: Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M
    J Neuroinflammation, 2016;13(1):24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine.
    Authors: Luci C, Bekri S, Bihl F, Pini J, Bourdely P, Nouhen K, Malgogne A, Walzer T, Braud V, Anjuere F
    PLoS ONE, 2015;10(12):e0143224.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
    Authors: Gomez D, Diehl M, Crosby E, Weinkopff T, Debes G
    J Immunol, 2015;195(8):3531-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages.
    Authors: Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H
    PLoS ONE, 2015;10(11):e0142920.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.
    Authors: Nabekura T, Girard J, Lanier L
    J Immunol, 2015;194(12):5948-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
    Eur J Immunol, 2015;45(4):1192-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Interleukin-36gamma is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.
    Authors: Bozoyan L, Dumas A, Patenaude A, Vallieres L
    J Neuroinflammation, 2015;12(0):173.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
    Nature, 2015;518(7539):417-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.
    Authors: Solt L, Banerjee S, Campbell S, Kamenecka T, Burris T
    Endocrinology, 2015;156(3):869-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
    Authors: Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S
    Mucosal Immunol, 2015;8(5):1099-109.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Adaptive Immune-like gamma/delta T Lymphocytes Share Many Common Features with Their alpha/beta T Cell Counterparts.
    Authors: Lombes A, Durand A, Charvet C, Riviere M, Bonilla N, Auffray C, Lucas B, Martin B
    J Immunol, 2015;195(4):1449-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
    Authors: Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K
    Nat Commun, 2015;6(0):6329.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. CXCL13 antibody for the treatment of autoimmune disorders.
    Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
    BMC Immunol, 2015;16(0):6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
    Authors: Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, Abughazleh M, Mansy M, Naura A, Boulares A
    J Allergy Clin Immunol, 2015;135(2):425-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.
    Authors: Walsh J, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens J, Gadani S, Hechler D, Golz G, Rosenberger K, Kammertons T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti T, Nitsch R, Zipp F, Kipnis J
    J Clin Invest, 2015;125(2):699-714.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
    Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
    J Immunol, 2015;194(6):2888-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.
    Authors: Beck B, Kim H, O'Brien R, Jadus M, Gillespie G, Cloud G, Hoa N, Langford C, Lopez R, Harkins L, Lamb L
    PLoS ONE, 2015;10(5):e0122387.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
    Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
    J Immunol, 2015;194(8):3634-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
    Authors: Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan D, Wu C, Rangachari M, Pertel T, Jin H, Ahmed R, Anderson A, Kuchroo V
    Nat Commun, 2015;6(0):6072.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
    Authors: Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff Y, Gilson E, Vivier E, Walzer T
    Nat Immunol, 2014;15(8):749-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
    Authors: Sriskantharajah S, Guckel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis P, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley S
    J Immunol, 2014;192(8):3518-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.
    Authors: Beaulieu A, Zawislak C, Nakayama T, Sun J
    Nat Immunol, 2014;15(6):546-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection.
    Authors: Min-Oo G, Lanier L
    J Exp Med, 2014;211(13):2669-80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells.
    Authors: Benkhoucha M, Molnarfi N, Dunand-Sauthier I, Merkler D, Schneiter G, Bruscoli S, Riccardi C, Tabata Y, Funakoshi H, Nakamura T, Reith W, Santiago-Raber M, Lalive P
    J Immunol, 2014;193(6):2743-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice.
    Authors: Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, Meng L, Sun H, Zhang Y, Guo Y, Hexner E, Zhang Y
    J Immunol, 2014;192(11):5012-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Distinct requirements for activation of NKT and NK cells during viral infection.
    Authors: Tyznik A, Verma S, Wang Q, Kronenberg M, Benedict C
    J Immunol, 2014;192(8):3676-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
    Authors: Chiba, Shiho, Ikushima, Hiroaki, Ueki, Hiroshi, Yanai, Hideyuki, Kimura, Yoshitak, Hangai, Sho, Nishio, Junko, Negishi, Hideo, Tamura, Tomohiko, Saijo, Shinobu, Iwakura, Yoichiro, Taniguchi, Tadatsug
    Elife, 2014;3(0):e04177.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Autocrine interleukin-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels.
    Authors: Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H
    Stem Cells, 2014;32(10):2799-810.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3.
    Authors: Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z
    J Immunol, 2014;192(12):5599-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. IL-18 expression results in a recombinant vaccinia virus that is highly attenuated and immunogenic.
    Authors: Verardi P, Legrand F, Chan K, Peng Y, Jones L, Yilma T
    J Interferon Cytokine Res, 2014;34(3):169-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes.
    Authors: Li C, Mueller E, Bradley L
    J Immunol, 2014;192(4):1425-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3.
    Authors: Wang J, Qian W, Liu J, Zhao J, Yu P, Jiang L, Zhou J, Gao R, Xiao H
    PLoS ONE, 2014;9(2):e88642.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.
    Authors: Stridh P, Ruhrmann S, Bergman P, Thessen Hedreul M, Flytzani S, Beyeen A, Gillett A, Krivosija N, Ockinger J, Ferguson-Smith A, Jagodic M
    PLoS Genet, 2014;10(3):e1004265.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.
    Authors: Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H
    J Immunol, 2014;192(1):59-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
    Authors: Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V
    J Immunol, 2014;192(8):3618-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells.
    Authors: Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S
    J Immunol, 2014;193(4):1728-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
    Authors: Bauer, Christia, Kim, Edward Y, Marangoni, Francesc, Carrizosa, Esteban, Claudio, Natalie, Mempel, Thorsten
    J Clin Invest, 2014;124(6):2425-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing.
    Authors: Allan E, Tailor P, Balce D, Pirzadeh P, McKenna N, Renaux B, Warren A, Jirik F, Yates R
    J Immunol, 2014;192(11):4989-5001.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation.
    Authors: Paul D, Ge S, Lemire Y, Jellison E, Serwanski D, Ruddle N, Pachter J
    J Neuroinflammation, 2014;11(0):10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
    Authors: Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, Uchino M, Ando Y, Nagafuchi S, Nishimura Y, Senju S
    PLoS ONE, 2014;9(12):e115198.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue.
    Authors: Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H
    Arterioscler Thromb Vasc Biol, 2014;34(1):34-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Altered IFN-gamma-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease.
    Authors: Eva M, Yuki K, Dauphinee S, Schwartzentruber J, Pyzik M, Paquet M, Lathrop M, Majewski J, Vidal S, Malo D
    J Immunol, 2014;192(1):259-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis.
    Authors: Stoolman J, Duncker P, Huber A, Segal B
    J Immunol, 2014;193(2):564-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Dok1 and Dok2 proteins regulate natural killer cell development and function.
    Authors: Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, Dalod M, Vivier E, Nunes J
    EMBO J, 2014;33(17):1928-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.
    Authors: Renkema K, Li G, Wu A, Smithey M, Nikolich-Zugich J
    J Immunol, 2014;192(1):151-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Astrocytes modulate the polarization of CD4+ T cells to Th1 cells.
    Authors: Beurel E, Harrington L, Buchser W, Lemmon V, Jope R
    PLoS ONE, 2014;9(1):e86257.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.
    Authors: Levanon, Ditsa, Negreanu, Varda, Lotem, Joseph, Bone, Karen Ra, Brenner, Ori, Leshkowitz, Dena, Groner, Yoram
    Mol Cell Biol, 2014;34(6):1158-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease.
    Authors: Graham K, Zhang J, Lewen S, Burke T, Dang T, Zoudilova M, Sobel R, Butcher E, Zabel B
    PLoS ONE, 2014;9(12):e112925.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014;211(9):1807-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity.
    Authors: Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, Jegou D, Bosch S, Bach J
    PLoS ONE, 2014;9(9):e106153.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.
    Authors: Berezhnoy, Alexey, Castro, Iris, Levay, Agata, Malek, Thomas R, Gilboa, Eli
    J Clin Invest, 2014;124(1):188-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  133. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
    Authors: Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, Huang C, Tan T
    J Immunol, 2014;192(4):1547-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
    Authors: Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder T, Sato S
    J Leukoc Biol, 2013;94(4):563-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
    Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
    J Immunol, 2013;191(11):5420-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  136. Lymphoid-tissue stromal cells coordinate innate defense to cytomegalovirus.
    Authors: Verma S, Wang Q, Chodaczek G, Benedict C
    J Virol, 2013;87(11):6201-10.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA (Standard)
  137. Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
    Authors: Beurel E, Kaidanovich-Beilin O, Yeh W, Song L, Palomo V, Michalek S, Woodgett J, Harrington L, Eldar-Finkelman H, Martinez A, Jope R
    J Immunol, 2013;190(10):5000-11.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
    Authors: Mascanfroni, Ivan D, Yeste, Ada, Vieira, Silvio M, Burns, Evan J, Patel, Bonny, Sloma, Ido, Wu, Yan, Mayo, Lior, Ben-Hamo, Rotem, Efroni, Sol, Kuchroo, Vijay K, Robson, Simon C, Quintana, Francisc
    Nat Immunol, 2013;14(10):1054-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
    Authors: Villegas-Mendez A, de Souza J, Lavelle S, Gwyer Findlay E, Shaw T, Van Rooijen N, Saris C, Hunter C, Riley E, Couper K
    PLoS Pathog, 2013;9(4):e1003293.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Bioassay
  140. Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity.
    Authors: Jeyanathan M, Damjanovic D, Shaler C, Lai R, Wortzman M, Yin C, Zganiacz A, Lichty B, Xing Z
    Mucosal Immunol, 2013;6(3):612-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Regulation and migratory role of P-selectin ligands during intestinal inflammation.
    Authors: Hoffmann U, Pink M, Lauer U, Heimesaat M, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U
    PLoS ONE, 2013;8(4):e62055.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.
    Authors: Bancerek J, Poss Z, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dolken L, Strobl B, Muller M, Taatjes D, Kovarik P
    Immunity, 2013;38(2):250-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.
    Authors: Filtjens, Jessica, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Vanhees, Mandy, Kerre, Tessa, Taghon, Tom, Vandekerckhove, Bart, Plum, Jean, Leclercq, Georges
    J Leukoc Biol, 2013;93(5):699-711.
  144. Galectin-9 functionally impairs natural killer cells in humans and mice.
    Authors: Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H
    J Virol, 2013;87(9):4835-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
    Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
    Arthritis Rheum, 2013;65(4):949-59.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
    Authors: Sutherland A, Joller N, Michaud M, Liu S, Kuchroo V, Grusby M
    J Immunol, 2013;190(8):3977-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
    Authors: Knosp C, Schiering C, Spence S, Carroll H, Nel H, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald D, Powrie F, Fallon P, Johnston J, Kissenpfennig A
    J Immunol, 2013;190(7):3235-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour.
    Authors: Nunez S, Saez J, Fernandez D, Flores-Santibanez F, Alvarez K, Tejon G, Ruiz P, Maldonado P, Hidalgo Y, Manriquez V, Bono M, Rosemblatt M, Sauma D
    Immunology, 2013;139(1):61-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.
    Authors: Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S
    Nature, 2012;487(7406):249-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
    Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
    Nat Med, 2012;19(1):57-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
    Nat. Med., 2012;1248(0):18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  153. NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.
    Authors: Kashiwada M, Cassel SL, Colgan JD
    EMBO J., 2011;30(10):2071-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
    Authors: DePaolo RW, Abadie V, Tang F
    Nature, 2011;471(7337):220-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  155. The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
    Authors: Jin W, Qi S, Luo H
    BMC Immunol., 2011;12(0):68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  156. T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production.
    Authors: Kim HS, Kim HS, Lee CW, Chung DH
    J. Immunol., 2010;184(8):4095-106.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  157. Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1.
    Authors: Xi H, Katschke KJ, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M
    J. Exp. Med., 2010;207(1):7-16, S1-5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  158. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
    Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
    Nat. Med., 2010;16(2):191-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  160. Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation.
    Authors: Johnson LD, Jameson SC
    J. Immunol., 2010;184(10):5604-11.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  161. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA.
    Authors: Perrot I, Deauvieau F, Massacrier C
    J. Immunol., 2010;185(4):2080-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Dissociated expression of natural killer 1.1 and T-cell receptor by invariant natural killer T cells after interleukin-12 receptor and T-cell receptor signalling.
    Authors: Emoto M, Shimizu T, Koike H, Yoshizawa I, Hurwitz R, Kaufmann SH, Emoto Y
    Immunology, 2010;129(1):62-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  163. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
    Authors: Yoshizaki A, Yanaba K, Iwata Y
    J. Immunol., 2010;185(4):2502-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  164. TIM-3: a novel regulatory molecule of alloimmune activation.
    Authors: Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
    J. Immunol., 2010;185(10):5806-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Expression of bioactive single-chain murine IL-12 in transgenic plants.
    Authors: Liu J, Dolan MC, Reidy M, Cramer CL
    J. Interferon Cytokine Res., 2009;28(0):381-92.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  166. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.
    Authors: Bourgeois E, Van LP, Samson M, Diem S, Barra A, Roga S, Gombert JM, Schneider E, Dy M, Gourdy P, Girard JP, Herbelin A
    Eur. J. Immunol., 2009;39(4):1046-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Capsular polysaccharide and the O-specific antigen impede antibody binding: a potential obstacle for the successful development of an extraintestinal pathogenic Escherichia coli vaccine.
    Authors: Russo TA, Beanan JM, Olson R, MacDonald U, Cope JJ
    Vaccine, 2009;27(3):388-95.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  168. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation.
    Authors: Cui W, Joshi NS, Jiang A, Kaech SM
    Vaccine, 2009;27(15):2177-87.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  169. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
    Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5954-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  170. Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow.
    Authors: Tokoyoda K, Zehentmeier S, Hegazy AN, Albrecht I, Grun JR, Lohning M, Radbruch A
    Immunity, 2009;30(5):721-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  171. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
    Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
    J. Exp. Med., 2009;206(1):69-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
    Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
    Nat. Med., 2009;15(10):1170-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009;183(10):6135-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism.
    Authors: Norman MU, Zbytnuik L, Kubes P
    Eur. J. Immunol., 2008;38(5):1368-80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  175. CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
    Authors: Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N
    J. Exp. Med., 2008;205(11):2643-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  176. Redox regulation of interleukin-4 signaling.
    Authors: Sharma P, Chakraborty R, Wang L, Min B, Tremblay ML, Kawahara T, Lambeth JD, Haque SJ
    Immunity, 2008;29(4):551-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production.
    Authors: Hayashi N, Yoshimoto T, Izuhara K, Matsui K, Tanaka T, Nakanishi K
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(37):14765-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  178. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.
    Authors: Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A
    Nat. Immunol., 2007;8(12):1372-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
    Authors: Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF
    J Ethnopharmacol, 2007;110(3):532-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  180. Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia.
    Authors: Salvatore CM, Fonseca-Aten M, Katz-Gaynor K, Gomez AM, Hardy RD
    Infect. Immun., 2007;76(2):732-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  181. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice.
    Authors: Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, Foley P, Ley K
    J. Immunol., 2007;179(12):8274-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  182. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
    Authors: Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW
    J. Invest. Dermatol., 2007;127(8):1964-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production.
    Authors: Lalli PN, Strainic MG, Lin F, Medof ME, Heeger PS
    J. Immunol., 2007;179(9):5793-802.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  184. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
    Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
    J. Allergy Clin. Immunol., 2007;119(3):662-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus.
    Authors: Kitajima M, Abe T, Miyano-Kurosaki N, Taniguchi M, Nakayama T, Takaku H
    Mol. Ther., 2007;16(2):261-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  186. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections.
    Authors: Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H
    Blood, 2007;109(11):4846-55.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  187. Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo.
    Authors: Chapgier A, Wynn RF, Jouanguy E, Filipe-Santos O, Zhang S, Feinberg J, Hawkins K, Casanova JL, Arkwright PD
    J. Immunol., 2006;176(8):5078-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
    Authors: Ogawa K, Funaba M, Chen Y, Tsujimoto M
    J. Immunol., 2006;177(10):6787-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Exogenous IL-12 suppresses experimental autoimmune encephalomyelitis (EAE) by tuning IL-10 and IL-5 levels in an IFN-gamma-dependent way.
    Authors: Berghmans N, Dillen C, Heremans H
    J. Neuroimmunol., 2006;176(1):63-75.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  190. Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
    Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
    Am. J. Pathol., 2006;168(6):1940-50.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  191. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
    Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
    J Ethnopharmacol, 2006;106(3):418-24.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  192. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis.
    Authors: Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A
    J. Immunol., 2006;177(12):8650-7.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  193. Increased sensitivity to Salmonella enterica serovar Typhimurium infection in mice undergoing withdrawal from morphine is associated with suppression of interleukin-12.
    Authors: Feng P, Wilson QM, Meissler JJ, Adler MW, Eisenstein TK
    Infect. Immun., 2005;73(12):7953-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  194. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
    Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
    Nat Immunol, 2005;6(11):1123-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  195. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005;302(1):172-81.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  196. Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
    Authors: Costa SK, Yshii LM, Poston RN, Muscara MN, Brain SD
    J. Neuroimmunol., 2005;171(1):99-109.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  197. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.
    Authors: Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA
    Blood, 2004;104(5):1404-10.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  198. TCR vaccines against a murine T cell lymphoma: a primary role for antibodies of the IgG2c class in tumor protection.
    Authors: Lambert SL, Okada CY, Levy R
    J. Immunol., 2004;172(2):929-36.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  199. Control of Leishmania major in the absence of Tyk2 kinase.
    Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
    Eur. J. Immunol., 2004;34(2):519-29.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  200. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.
    Authors: Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW
    J. Immunol., 2003;171(10):5107-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  201. IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1.
    Authors: Russell TD, Yan Q, Fan G, Khalifah AP, Bishop DK, Brody SL, Walter MJ
    J. Immunol., 2003;171(12):6866-74.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  202. STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
    Authors: O&amp;amp;apos;shea JJ
    Proc. Natl. Acad. Sci. U.S.A., 2002;99(19):12281-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  203. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
    Authors: Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O&amp;amp;apos;Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW
    J. Immunol., 2002;168(11):5699-708.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  204. Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis.
    Authors: Ifergan I, Chen S, Zhang B, Miller S
    J Immunol, 0;196(4):1455-9.
    Species: Mouse
    Sample Types: In Vivo
  205. Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
    Authors: A Martin, C Seignez, C Racoeur, N Isambert, Isambert N, Mabrouk N, N Mabrouk, A Scagliarin, Scagliarini A, Reveneau S, S Reveneau, L Arnould, Arnould L, A Bettaieb, JF Jeannin, Jeannin J, C Paul
    Oncotarget, 0;9(47):28364-28378.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. What is the extra band observed when running Recombinant Mouse IL-12 Protein (Catalog # 419-ML) in Western blot?

    • Recombinant mouse IL‑12 preparations were proteolytically cleaved between residues G158 and E159 of the mature p35 subunit. Thus, under reducing conditions, three bands representing the p40 subunit, the p35 R1 ‑ G158 peptide and the p35 E159 - A193 peptide can be observed in SDS-PAGE.

  2. Should I use Recombinant Mouse IL-12 Protein formulated with carrier BSA (Catalog # 419-ML) or the Recombinant Mouse IL-12 Protein, CF (Catalog # 419-ML/CF) that is carrier-free (no BSA) for my in vivo experiments?

    • For in vivo aplications, we would recommend using the carrier-free Recombinant Mouse IL-12 Protein (Catalog # 419-ML/CF). The injection of a carrier protein such as BSA can cause side effects and sometimes death to the experimental animal. For more information regarding use of the protein for in vivo applications, we would recommend consulting the Citations tab on the product-specific page.

  3. Is there a mass to unit conversion factor for Recombinant Mouse IL-12 Protein (Catalog # 419-ML & 419-ML/CF)?

    • We have not developed a specific mass to unit conversion factor for Recombinant Mouse IL-12 Protein (Catalog # 419-ML & 419-ML/CF).  Our best recommendation is to perform a dose-response study for your assay to determine the optimal concentration for your experiment.  We recommend checking the Citations tab on the product-specific page to review publications citing use of the product.

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Reviews for Recombinant Mouse IL-12 Protein

Average Rating: 4.7 (Based on 7 Reviews)

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Recombinant Mouse IL-12 Protein
By Anonymous on 11/09/2020
Application: CellProlif

Recombinant Mouse IL-12 Protein
By Anonymous on 05/23/2020
Application: CellProlif

Recombinant Mouse IL-12 Protein
By Anonymous on 12/02/2019
Application: In vitro bioactivity in cell culture

Recombinant Mouse IL-12 Protein
By Anonymous on 01/22/2018
Application: Binding assay/Protein-protein interaction

Recombinant Mouse IL-12 Protein
By Anonymous on 11/27/2017
Application: Immunoassay Standard

This protein was used as the calibrator in an ELISA using MAB419 and BAF419 as the matched pair antibodies.


Recombinant Mouse IL-12 Protein
By Anonymous on 08/24/2017
Application: CD4+ T cell polarization toward Th1

Recombinant Mouse IL-12 Protein
By Anonymous on 01/21/2016
Application: In vitro bioactivity in cell culture