Recombinant Mouse TREM-1 Fc Chimera Protein, CF Summary
Accession # Q9JKE2
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. Engagement of TREM-1 with a monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock.
- Bouchon, A. (2000) J. Immunol. 164:4991.
- Bouchon, A. (2001) Nature 410:1103.
- Nathan, C. and A. Ding (2001) Nature Med. 7:530.
Citations for Recombinant Mouse TREM-1 Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
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Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis
Authors: NL Denning, M Aziz, A Murao, SD Gurien, M Ochani, JM Prince, P Wang
JCI Insight, 2020;0(0):.
Enhanced expression of TREM-1 in splenic cDCs in lupus prone mice and it was modulated by miRNA-150
Authors: Sheng Gao
Mol. Immunol, 2017;81(0):127-134.
Sample Types: Whole Cells
TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and Th1/Th2-type immune responses.
Authors: Wu M, Peng A, Sun M, Deng Q, Hazlett L, Yuan J, Liu X, Gao Q, Feng L, He J, Zhang P, Huang X
Infect Immun, 2011;79(7):2709-16.
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
Authors: Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE
J. Neurochem., 2009;109(4):1144-56.
Sample Types: Whole Cells
Applications: Flow Cytometry
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