Chemical Name: 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Biological ActivityRilmenidine hemifumarate is an I1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Possesses greater I1 vs α2 selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams et al.
Rilmenidine selectivity for imidazoline receptors in human brain.
Bricca et al.
Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs.
Mammoto et al.
Keeping an eye on the I site: imidazoline-preferring receptors.
Michel and Ernsberger
Human brain imidazoline receptors: Further characterisation with [3H] clon.
Bricca et al.
Citation for Rilmenidine hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for Rilmenidine hemifumarate include:
1 Citation: Showing 1 - 1
Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Authors: Sánchez-Blázquez Et al.
Br J Pharmacol 2000;130:146
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