Rilmenidine hemifumarate

Key Product Details

Product Description

Rilmenidine hemifumarate is an I₁-imidazoline binding site selective ligand and α₂-adrenoceptor agonist. Possesses greater I₁ vs α₂ selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Product Specifications for Rilmenidine hemifumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rilmenidine hemifumarate

The following data is based on the product molecular weight 238.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	16.79 mL	83.93 mL	167.86 mL
1.25 mM	3.36 mL	16.79 mL	33.57 mL
2.5 mM	1.68 mL	8.39 mL	16.79 mL
12.5 mM	0.34 mL	1.68 mL	3.36 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 2008 PMID: 18391949
• Michel and Ernsberger Keeping an eye on the I site: imidazoline-preferring receptors. TiPS 1992 PMID: 1413085
• Bricca Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol. 1989 PMID: 2566507
• Mammoto Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol. 1996 PMID: 8732285
• Bricca Human brain imidazoline receptors: Further characterisation with [³H] clon. Eur.J.Pharmacol. 1994 PMID: 8137880

Product Documents for Rilmenidine hemifumarate