Catalog Number: 0790
Chemical Name: 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Biological Activity
I1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Possesses greater I1 vs α2 selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
Technical Data
  • M.Wt:
    238.29
  • Formula:
    C10H16N2O.½C4H4O4
  • Solubility:
    Soluble to 25 mM in DMSO and to 25 mM in ethanol and to 25 mM in water
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    207572-68-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
    Williams et al.
    Nat.Chem.Biol., 2008;4:295
  2. Human brain imidazoline receptors: Further characterisation with [3H] clonidine.
    Bricca et al.
    Eur.J.Pharmacol., 1994;266:25
  3. Rilmenidine selectivity for imidazoline receptors in human brain.
    Bricca et al.
    Eur.J.Pharmacol., 1989;163:373
  4. Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs.
    Mammoto et al.
    Br.J.Pharmacol., 1996;117:1744
  5. Keeping an eye on the I site: imidazoline-preferring receptors.
    Michel and Ernsberger
    TIPS, 1992;13:369
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rilmenidine hemifumarate include:

1 Citations: Showing 1 - 1

  1. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
    Authors: Sánchez-Blázquez Et al.
    Br J Pharmacol 2000;130:146

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